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Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats.
Suzuki Jun, Manola Akrivi, Murakami Yusuke, Morizane Yuki, Takeuchi Kimio, Kayama Maki et al.
Invest Ophthalmol Vis SciAug 201126 citationsBasic Science
AICAR significantly reduced inflammation in rat endotoxin-induced uveitis by suppressing inflammatory mediators and pathways. This suggests AICAR could be a novel therapeutic agent for ocular inflammation.