Kolovos Antonia

Kolovos Antonia, Aung Tin, Khawaja Anthony P, Wiggs Janey L, Craig Jamie E

Polygenic risk scores (PRS) for glaucoma show promise in improving early diagnosis and predicting disease course, offering personalized risk assessment to enhance clinical management.

Kolovos Antonia, Qassim Ayub, Hassall Mark M, Marshall Henry N, Schmidt Joshua, Nguyen Thi Thi et al.

Polygenic risk scores for glaucoma, IOP, and VCDR stratify glaucoma risk and severity in pseudoexfoliation patients, identifying those prone to earlier diagnosis and worse outcomes, aiding personalized management.

Kolovos Antonia, Maxwell Giorgina, Souzeau Emmanuelle, Craig Jamie E

This review highlights that understanding glaucoma genetics (monogenic/polygenic) offers clinicians valuable information for personalized risk assessment and treatment, moving towards precision medicine in glaucoma care.

Aboobakar Inas F, Kinzy Tyler G, Zhao Yan, Fan Baojian, Pasquale Louis R, Qassim Ayub et al.

Studying TXNRD2/ME3 genetic risk scores in POAG, researchers found higher scores linked to increased treated IOP and paracentral visual field loss, suggesting these genes influence specific glaucoma phenotypes.

Mullany Sean, Diaz-Torres Santiago, Schmidt Joshua M, Thomson Daniel, Qassim Ayub, Marshall Henry N et al.

This large study found no strong association between the APOE E4 allele and glaucoma, suggesting it's not a significant genetic risk factor for the disease.

Qassim Ayub, Mullany Sean, Abedi Farshad, Marshall Henry, Hassall Mark M, Kolovos Antonia et al.

Corneal stiffness and thinness predict faster structural and functional glaucoma progression in suspect eyes, indicating these factors identify individuals at higher risk for disease worsening.