Kuchtey John

Kuchtey Rachel W, Insignares Samuel, Yang Tzushan S, Kuchtey John

Researchers studied double mutant mice with combined elastic fiber and microfibril defects as a model for Exfoliation Syndrome. These mice showed severe systemic and ocular abnormalities, but not elevated eye pressure, suggesting early retinal dysfunction and a link to systemic diseases.

Wu Hang-Jing, Mortlock Douglas P, Kuchtey Rachel W, Kuchtey John

Mice with an Adamts10 glaucoma mutation showed Weill-Marchesani-like features and altered ocular fibrillin composition, suggesting this gene impacts microfibril regulation, relevant for understanding connective tissue disorders and glaucoma.

Wu Hang-Jing, Kuchtey John, Kuchtey Rachel W

Microfibril-deficient mice showed increased susceptibility to glaucoma, experiencing greater retinal ganglion cell and axon loss despite lower pressure elevation, highlighting connective tissue's role in disease vulnerability.

Hazlewood Ralph J, Kuchtey John, Wu Hang-Jing, Kuchtey Rachel W

This study found telmisartan, an ARB, significantly reduced optic nerve axon degeneration in mice with experimental glaucoma, suggesting its potential neuroprotective role beyond IOP lowering.

Kuchtey John, Kunkel Jessica, Esson Douglas, Sapienza John S, Ward Daniel A, Plummer Caryn E et al.

This study confirmed the ADAMTS10 Gly661Arg variant as the likely cause of primary open-angle glaucoma in beagles, ruling out other genetic candidates. This pinpoints a specific genetic defect for beagle glaucoma.

Kuchtey John, Rezaei Kasra A, Jaru-Ampornpan Pimkwan, Sternberg Paul, Kuchtey Rachel W

This study found significantly elevated IL-8 in glaucoma patients' aqueous humor, especially in more severe cases, suggesting immune activation contributes to glaucoma pathogenesis.

Kuchtey John, Källberg Maria E, Gelatt Kirk N, Rinkoski Tommy, Komàromy András M, Kuchtey Rachel W

Glaucoma stimuli increase ANGPTL7 secretion, found elevated in glaucomatous aqueous humor, and it promotes collagen expression. This suggests ANGPTL7 may contribute to glaucoma and could be a therapeutic target.