Larsen Michael

Boberg-Ans Lars Christian, Munch Inger Christine, Olsen Else Marie, Skovgaard Anne Mette, Larsen Michael

Gunn dots were common in healthy 11-12 year olds, with more dots linked to thicker nerve fiber layers and older age. Their clinical significance remains unknown, but their location makes them relevant to retinal interface conditions.

Carstensen Christopher Voigt, Bjerager Jakob, Belmouhand Mohamed, Eckmann-Hansen Christina, Rothenbuehler Simon P, Dabbah Sami et al.

This twin study found retinal artery wall-to-lumen ratio increases with age and blood pressure, with environmental factors, not genetics, primarily influencing the blood pressure link, highlighting environmental impact on vascular health.

Eckmann-Hansen Christina, Bek Toke, Sander Birgit, Larsen Michael

This study found that longer gestational age and higher birth weight may improve visual function and retinal structure in ADOA, suggesting early life factors influence disease severity.

Zhu Linna, Munch Inger Christine, Pedersen Casper-Emil T, Stokholm Jakob, Bønnelykke Klaus, Chawes Bo et al.

This study found early life smoke exposure (maternal pregnancy, fetal/childhood) is linked to thinner optic nerve fibers and macula in young adults, suggesting vulnerability during development.

Behrens Christopher Maximilian, Malmqvist Lasse, Jørgensen Morten, Sibony Patrick A, Munch Inger Christine, Skovgaard Anne Mette et al.

This study found PHOMS in 8.9% of children, linked to myopia and tilted optic discs. Given their prevalence, PHOMS alone shouldn't signify optic neuropathy.

Stefansson Einar, Loftsson Thorstein, Larsen Michael, Papp András, Kaarniranta Kai, Munk Marion R et al.

Topical dexamethasone (OCS-01) significantly reduced central macular thickness in diabetic macular edema, showing promising visual improvement, especially in patients with worse baseline vision, suggesting a non-invasive treatment option.

Chung Daniel C, Bertelsen Mette, Lorenz Birgit, Pennesi Mark E, Leroy Bart P, Hamel Christian P et al.

This study found that RPE65-related inherited retinal dystrophy causes progressive vision loss with age, but no genotype-phenotype correlation. Genetic testing is crucial for diagnosis and treatment timing.

Corajevic Nihada, Larsen Michael, Rönnbäck Cecilia

OCT in ADOA showed the ganglion cell layer (GCL) in the nasal perifoveal area and temporal peripapillary RNFL are most thinned, serving as key diagnostic markers.

Ashina Håkan, Li Xiao Qiang, Olsen Else Marie, Skovgaard Anne Mette, Larsen Michael, Munch Inger Christine

This study found maternal smoking during pregnancy and low birth weight independently predict thinner retinal nerve fiber layers in 11-12 year olds, highlighting lasting impacts on eye health and reinforcing smoking avoidance during pregnancy.

Ba-Ali Shakoor, Christensen Søren Kirchhoff, Sander Birgit, Rosenberg Thomas, Larsen Michael, Lund-Andersen Henrik

Choroideremia patients showed normal melanopsin-driven pupil constriction but abnormally slow post-illumination pupil relaxation after blue light, suggesting impaired photoreceptor inhibition on the melanopsin system.

Boberg-Ans Lars C, Munch Inger C, Larsen Michael, Gopinath Bamini, Wang Jie Jin, Mitchell Paul

Gunn's dots are common in adolescents, often found near the optic disc, and associated with darker irides and thicker retinal nerve fiber layers. They appear harmless, but long-term follow-up is needed.

Rönnbäck Cecilia, Nissen Claus, Almind Gitte J, Grønskov Karen, Milea Dan, Larsen Michael

This study found OPA1 gene mutations cause varying inner retinal thinning with age, explaining different visual loss progression in autosomal-dominant optic atrophy.

Rönnbäck Cecilia, Milea Dan, Larsen Michael

OCT imaging in autosomal-dominant optic atrophy (ADOA) found early, severe macular ganglion cell thinning, indicating structural damage is complete from childhood. This offers a sensitive diagnostic marker and insight into early disease progression.

Kofoed Peter Kristian, Munch Inger Christine, Holfort Stig K, Sillesen Henrik, Jensen Leif Panduro, Iversen Helle K et al.

This study found that eyes with higher carotid stenosis and lower ophthalmic artery pressure show impaired cone function, suggesting systemic blood pressure impacts retinal health in these patients.

Milea Dan, Sander Birgit, Wegener Marianne, Jensen Hanne, Kjer Birgit, Jørgensen Thomas Martini et al.

This study found dominant optic atrophy patients have early, constant RNFL loss from a young age, leading to age-related visual decline, highlighting early disease onset.

Kofoed Peter Kristian, Munch Inger Christine, Sander Birgit, Holfort Stig K, Sillesen Henrik, Jensen Leif Panduro et al.

mfERG showed prolonged retinal signal timing (implicit times) in ocular ischemic syndrome, indicating suppressed outer/middle retinal function due to chronic hypoperfusion, which may be an adaptive response.

Vinten Martin, la Cour Morten, Lund-Andersen Henrik, Larsen Michael

This study found DMO patients' macular edema worsened when lying down, linked to impaired retinal artery constriction seen in healthy eyes, suggesting a novel pathophysiological mechanism.

Zibrandtsen Nathalie, Munch Inger Christine, Klemp Kristian, Jørgensen Thomas Martini, Sander Birgit, Larsen Michael

AZOOR patients without visible fundus changes show photoreceptor atrophy on OCT, explaining vision loss and abnormal ERG, highlighting subclinical retinal damage.

Hougaard Jesper Leth, Kessel Line, Sander Birgit, Kyvik Kirsten Ohm, Sørensen Thorkild I A, Larsen Michael

This twin study found retinal nerve fiber layer thickness (RNFLT) is predominantly determined by genetic factors (66-82% heritability) in healthy adults, suggesting inherited baseline variations influence glaucoma risk assessment.