Leske M Cristina

Heijl Anders, Leske M Cristina, Hyman Leslie, Yang Zhongming, Bengtsson Boel

This study found that a fixed glaucoma treatment's IOP reduction strongly depends on baseline pressure, with minimal effect below 15 mmHg. This highlights the importance of reporting baseline IOP in treatment outcomes.

Heijl Anders, Peters Dorothea, Leske M Cristina, Bengtsson Boel

This study found ALT significantly lowers IOP, especially in eyes with higher pre-treatment IOP, and surgeon technique impacts outcomes, guiding patient selection and procedural consistency.

Leske M Cristina, Wu Suh-Yuh, Nemesure Barbara, Hennis Anselm

Heijl Anders, Bengtsson Boel, Hyman Leslie, Leske M Cristina

This EMGT study found untreated glaucoma progression rates vary significantly by type, with pseudoexfoliation glaucoma progressing fastest and normal-tension glaucoma slowest, informing prognosis and treatment urgency.

Leske M Cristina

Low ocular perfusion pressure is consistently linked to increased open-angle glaucoma risk, incidence, and progression, suggesting impaired optic disc blood flow is a key vascular factor in the disease.

Bengtsson Boel, Leske M Cristina, Yang Zhongming, Heijl Anders

IOP-lowering treatment did not reduce disc hemorrhages in early glaucoma patients, suggesting these hemorrhages aren't solely due to insufficient IOP control and progression may occur despite treatment.

Heijl Anders, Bengtsson Boel, Chauhan Balwantray C, Lieberman Marc F, Cunliffe Ian, Hyman Leslie et al.

This study compared glaucoma trial visual field progression criteria, finding EMGT criteria detected progression earliest and most frequently, but with slightly lower specificity, impacting early intervention decisions.

Wu Suh-Yuh, Hennis Anselm, Nemesure Barbara, Leske M Cristina

This study found glaucoma, posterior subcapsular cataracts, and aphakic cataract surgery significantly lowered vision-related quality of life in a Black population, highlighting needs for targeted patient care and public health policies.

Leske M Cristina, Wu Suh-Yuh, Hennis Anselm, Honkanen Robert, Nemesure Barbara

This study found that older age, family history, high IOP, low blood pressure/ocular perfusion, and thin corneas increase glaucoma risk in African-descent individuals, highlighting its multifactorial nature for screening.

Leske M Cristina, Heijl Anders, Hyman Leslie, Bengtsson Boel, Dong LiMing, Yang Zhongming

This study identified new glaucoma progression predictors—lower perfusion pressure, cardiovascular disease, and thinner corneas—beyond IOP and established risk factors, highlighting vascular health's role in disease management.

Nemesure B, Honkanen R, Hennis A, Wu S Y, Leske M Cristina

This study found baseline IOP strongly predicts OAG risk in people of African origin, with higher IOP increasing risk, but many cases still occurred at lower pressures, highlighting IOP's predictive value and limitations.

Hennis Anselm, Wu Suh-Yuh, Nemesure Barbara, Honkanen Robert, Leske M Cristina

Over half of incident glaucoma cases were unaware. Unawareness linked to lower IOP, hyperopia, and infrequent comprehensive eye exams, especially when eye care was from opticians, highlighting detection gaps.

Leske M Cristina, Wu S Y, Honkanen R, Nemesure B, Schachat A, Hyman L et al.

This study found a high 9-year open-angle glaucoma incidence (4.4% definite) in African-descent individuals, increasing with age and higher in men. This highlights significant long-term risk and public health implications.

Bengtsson Boel, Leske M Cristina, Hyman Leslie, Heijl Anders

This study found that while higher mean IOP is a strong risk factor for glaucoma progression, IOP fluctuation itself was not an independent predictor of progression in early manifest glaucoma.

Wu Suh-Yuh, Yoo Yun Joo, Nemesure Barbara, Hennis Anselm, Leske M Cristina

This 9-year study found older adults experience significant refractive shifts; nuclear cataracts, glaucoma, and diabetes increase older-onset myopia risk, highlighting the need for monitoring.

Hyman Leslie G, Komaroff Eugene, Heijl Anders, Bengtsson Bo, Leske M Cristina

This study found early glaucoma treatment didn't impact vision-related quality of life, but visual function (acuity, field) significantly affected it for up to six years.

Leske M Cristina, Heijl Anders, Hyman Leslie, Bengtsson Bo, Komaroff Eugene

The EMGT found early glaucoma treatment (IOP lowering) halved progression risk, highlighting its value, while age and disease severity also predicted worsening.**

Leske M Cristina

Hennis Anselm, Wu Suh-Yuh, Nemesure Barbara, Leske M Cristina

This study found hypertension and diabetes are associated with increased intraocular pressure over four years in a Black population, highlighting their impact on glaucoma risk.