Li Ning

2 articles in GJC

MiR-29b Downregulation by p53/Sp1 Complex Plays a Critical Role in Bleb Scar Formation After Glaucoma Filtration Surgery.

Li Ning, Wang Zixi, Yang Fan, Hu Wenjun, Zha Xiaojun, Duan Xuanchu

Transl Vis Sci TechnolDec 20236 citationsBasic Science

This study found that the p53/Sp1 complex downregulates miR-29b, promoting bleb scarring after glaucoma surgery. Targeting this pathway could prevent surgical failure.

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Suppression of Type I Collagen Expression by miR-29b Via PI3K, Akt, and Sp1 Pathway, Part II: An In Vivo Investigation.

Yu Juan, Luo Haomin, Li Ning, Duan Xuanchu

Invest Ophthalmol Vis SciSep 20150 citationsBasic Science

Lentivirus-mediated miR-29b reduced scarring, lowered IOP, and improved bleb function after glaucoma surgery in rabbits by inhibiting fibroblast proliferation and collagen deposition, suggesting a novel anti-scarring therapy.

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Li Ning

MiR-29b Downregulation by p53/Sp1 Complex Plays a Critical Role in Bleb Scar Formation After Glaucoma Filtration Surgery.

Suppression of Type I Collagen Expression by miR-29b Via PI3K, Akt, and Sp1 Pathway, Part II: An In Vivo Investigation.