Liu Wei

Guo Ruru, Song Mengxue, Liu Wei

Higher serum Klotho levels were linked to increased glaucoma prevalence, but causality was not established genetically. This suggests Klotho could be a glaucoma biomarker, but its ocular role needs further local investigation.

Liu Wei, Guo Ruru, Wang Siqi, Chen Zekai, Song Mengxue, Faro Valeria Lo et al.

Contrary to expectations, chronic kidney disease (low eGFR) showed no direct glaucoma association. Instead, higher eGFR was paradoxically linked to increased glaucoma risk in large cohorts, suggesting a complex or inverse relationship warrants further investigation into underlying mechanisms.

Ye Guitong, Zhang Yuan, Huang Shaofen, Zhan Jinan, Luo Ruiyu, Xie Rui et al.

This study in macaques found high myopia correlates with reduced choroidal thickness/vascularity. Axial length significantly impacts adult choroidal parameters, with CVI being an early indicator, aiding myopia research.

Zhang Yuan, Ye Guitong, Chen Kezhe, Huang Shaofen, Xie Rui, Chen Jianqi et al.

This study found that retinal nerve fiber and macular ganglion cell layer thicknesses in cynomolgus macaques, and their associations with age, axial length, and refractive error, closely resemble humans, validating them as glaucoma models.

Manners Siobhan, Morgan William, Morlet Nigel, Meuleners Lynn, Liu Wei, Morlet Hector et al.

This study developed a protocol to aggregate 600,000+ visual field tests from Western Australia (1988-2022) into a large, representative database. This resource enables population-level glaucoma research, improving our understanding of visual field disorders.

Tian Jiaxin, Wu Jian, Liu Wei, Chen Kezhe, Zhu Sirui, Lin Caixia et al.

This macaque study found high myopia is strongly associated with increased fundus tessellation and parapapillary atrophy, validating macaques as a valuable model for human high myopia research.

Zhou Jiaxing, Lin Sen, Hu Qiumei, Li Xue, Chen Xi, Luo Linlin et al.

Studying optic nerve injury, researchers found that knocking out microglial CD11b enhanced debris clearance via IGF-1, preserving more axons. Inhibiting CD11b may promote nerve repair.

Liu Wei, Guo Ruru, Huang Dandan, Ji Jian, Gansevoort Ron T, Snieder Harold et al.

This review found glaucoma is often elevated in CKD patients and vice versa, suggesting a complex, partially understood link with shared mechanisms.

Huang Dandan, Xu Chenjia, Guo Ruru, Ji Jian, Liu Wei

The anterior lens capsule's biomechanics make it an excellent scaffold for ocular cell culture and a promising therapeutic material for treating glaucoma, corneal ulcers, and other eye diseases.

Xuan Yi, Zhang Youjia, Zong Yuan, Wang Min, Li Lei, Ye Xiaofeng et al.

This study of Chinese vitelliform macular dystrophy patients found specific genetic mutations, and importantly, that BEST1-related cases had varying ocular biometrics, with some showing increased risk for angle-closure glaucoma.

Gao Ling, Xiao Hang, Ai Li-Qian-Yu, Chen Chunlin, Lin Sen, Zhou Yuanguo et al.

Vps35 deficiency impairs Cdk5/p35 degradation, leading to tau hyperphosphorylation and RGC degeneration. Targeting Vps35 or Cdk5 could offer new glaucoma treatments.

Liu Wei, Xia Fan, Ha Yonju, Zhu Shuang, Li Yi, Folorunso Oluwarotimi et al.

This study found HSF1 protects retinal neurons from ischemia-reperfusion injury by reducing cell death and inflammation. Boosting HSF1 could be a strategy to prevent vision loss in retinal diseases.

Ha Yonju, Liu Wei, Liu Hua, Zhu Shuang, Xia Fan, Gerson Julia E et al.

AAV2-GRP78 gene therapy in a mouse model of optic nerve injury reduced RGC death by decreasing ER stress and tau oligomers, suggesting a novel therapeutic approach for RGC protection in conditions like glaucoma.

Liu Wei, Xing Xiaoli, Liu Aihua, Ji Jian