Li Lei

Huo Yanjiao, Thomas Ravi, Guo Yan, Zhang Wei, Li Lei, Cao Kai et al.

This study found macular microcirculation significantly declined in mild and severe glaucoma, but not between mild and moderate stages, linking it to age, visual field loss, and nerve thinning.

Yao Yao, Fu Jing, Li Lei, Chen Weiwei, Meng Zhaojun, Su Han et al.

This study established normal retinal and nerve fiber layer thickness in Tibetan children, finding sex differences and correlations with IOP, BMI, and refractive error, aiding glaucoma diagnosis in this population.

Zhang Ye, Dong Zhe, Zhang Qing, Li Lei, Thomas Ravi, Li Si Zhen et al.

Prediction models using ASOCT effectively detect primary angle-closure suspects, performing best for pupillary block mechanisms, offering potential for improved screening of this glaucoma risk.

Huo Yan Jiao, Thomas Ravi, Li Lei, Cao Kai, Wang Huai Zhou, Wang Ning Li

This study found specific pRNFL subzones (inferior/superior temporal) perform similarly to mean pRNFL and mGCIPL in detecting glaucoma across all severities, aiding targeted diagnosis.

Zhang Zheng, Wu Shen, Liu Kegao, Zhang Jingxue, Liu Qian, Li Lei et al.

This rat study found reduced cerebrospinal fluid pressure impairs optic nerve axonal transport after 3 hours, worsening over time. This suggests CSFP reduction contributes to glaucoma's nerve damage.

Zhang Ye, Zhang Qing, Li Lei, Thomas Ravi, Li Si Zhen, He Ming Guang et al.

Algorithms combining ASOCT parameters to detect primary angle closure suspects were evaluated. They did not meet population screening requirements, highlighting the complexity of angle closure mechanisms, but advance image-based screening research.

Xuan Yi, Zhang Youjia, Zong Yuan, Wang Min, Li Lei, Ye Xiaofeng et al.

This study of Chinese vitelliform macular dystrophy patients found specific genetic mutations, and importantly, that BEST1-related cases had varying ocular biometrics, with some showing increased risk for angle-closure glaucoma.

Huo Yan J, Guo Yan, Li Lei, Wang Huai Z, Wang Ya X, Thomas Ravi et al.

This study found mGCIPL thickness linearly decreases with age, with steep drops in the fifth and seventh decades, and is associated with pRNFL and IOP. This helps interpret OCT scans for glaucoma progression.

Zhang Ye, Li Si Zhen, Li Lei, He Ming Guang, Thomas Ravi, Wang Ning Li

This study found dynamic iris changes, specifically less iris area loss during pupil dilation, are a risk factor for primary angle closure disease, highlighting its role in disease development.

Zhang Zheng, Liu Danli, Jonas Jost B, Wu Shen, Kwong Jacky M K, Zhang Jingxue et al.

Zhu Xiaoyan, Xu Duo, Zhu Xiaomin, Li Lei, Li Haijun, Guo Feng et al.

A chitosan/aptamer gel targeting TGF-β RII reduced scarring and improved filtration in rat glaucoma surgery, suggesting a promising new antifibrotic treatment to prevent surgical failure.

Zhang Zheng, Liu Danli, Jonas Jost B, Wu Shen, Kwong Jacky M K, Zhang Jingxue et al.

Both short-term low CSFP and high IOP disrupted axonal transport in rats. This suggests abnormally low CSFP, like high IOP, can harm the optic nerve, impacting glaucoma understanding.

Zhang Zheng, Wang Xiaolei, Jonas Jost B, Wang Huaizhou, Zhang Xiaojun, Peng Xiaoxia et al.

Zhang Ye, Li Si Zhen, Li Lei, He Ming Guang, Thomas Ravi, Wang Ning Li

This study found iris area changes after dilation differ significantly among angle closure mechanisms; pupillary block eyes showed the least change, suggesting dynamic iris behavior is crucial in this type.

Zhang Zheng, Wang Xiaolei, Jonas Jost B, Wang Huaizhou, Zhang Xiaojun, Peng Xiaoxia et al.

Valsalva maneuver increases CSF-P more than IOP, transiently reversing trans-laminar pressure difference, altering optic nerve head shape. This suggests mechanical stress on the optic nerve is complex and relevant to glaucoma.