Age-related changes in and determinants of macular ganglion cell-inner plexiform layer thickness in normal Chinese adults.
Huo Yan J, Guo Yan, Li Lei, Wang Huai Z, Wang Ya X, Thomas Ravi, Wang Ning L
AI Summary
This study found mGCIPL thickness linearly decreases with age, with steep drops in the fifth and seventh decades, and is associated with pRNFL and IOP. This helps interpret OCT scans for glaucoma progression.
Abstract
Importance
Consideration of age-related changes in macular ganglion cell-inner plexiform layer (mGCIPL) thickness are important for glaucoma progression analysis.
Background
To report age-related changes in and the determinants of high-definition optical coherence tomography (HD-OCT) measurements of mGCIPL thickness.
Design
Cross-sectional study.
Participants
326 healthy adults.
Methods
All subjects underwent Cirrus HD-OCT measurements of mGCIPL. One-way analysis of variance (ANOVA) was used to compare mGCIPL thickness between 7 decades based age groups and macular sectors. Multiple regression analysis determined the association between mGCIPL thickness and age, gender, intraocular pressure (IOP), peripapillary retinal nerve fibre layer thickness (pRNFL) and spherical equivalent.
Main outcome measures
Change in mGCIPL thickness and determinants of thickness.
Results
Mean mGCIPL thickness in 295 subjects was 80.80 ± 6.42 μm. Mean mGCIPL decreased by 0.12 μm (95% CI [confidence interval], 0.09-0.16) with every year of age; 1.61 μm (95% CI, 0.08-2.41) per decade. It showed two steep declines with age, first in the fifth and next in the seventh decade with relative stability between them. mGCIPL thickness was associated with pRNFL thickness (β = 0.30, P < 0.001) and IOP (β = -0.19, P = 0.03) but not with gender (β = -1.09, P = 0.116) or spherical equivalent (β = -0. 24, P = 0.145).
Conclusions and relevance: Mean mGCIPL thickness showed a small age-related linear decrease with two steep drops in the fifth and seventh decades. Thinner mGCIPL was independently associated with age, thinner pRNFL and higher IOP. These factors should be considered if using mGCIPL to detect progression of glaucoma and other optic neuropathies characterized by the loss of retinal ganglion cells.
MeSH Terms
Shields Classification
Key Concepts5
In a cross-sectional study of 295 healthy Chinese adults, the mean macular ganglion cell-inner plexiform layer (mGCIPL) thickness was 80.80 ± 6.42 μm.
In a cross-sectional study of 295 healthy Chinese adults, mean macular ganglion cell-inner plexiform layer (mGCIPL) thickness decreased by 0.12 μm (95% CI, 0.09-0.16) with every year of age, or 1.61 μm (95% CI, 0.08-2.41) per decade.
In a cross-sectional study of 295 healthy Chinese adults, macular ganglion cell-inner plexiform layer (mGCIPL) thickness showed two steep declines with age, first in the fifth and next in the seventh decade, with relative stability between them.
In a cross-sectional study of 295 healthy Chinese adults, macular ganglion cell-inner plexiform layer (mGCIPL) thickness was associated with peripapillary retinal nerve fibre layer thickness (pRNFL) (β = 0.30, P < 0.001) and intraocular pressure (IOP) (β = -0.19, P = 0.03), but not with gender (β = -1.09, P = 0.116) or spherical equivalent (β = -0.24, P = 0.145).
In a cross-sectional study of 295 healthy Chinese adults, thinner macular ganglion cell-inner plexiform layer (mGCIPL) was independently associated with age, thinner peripapillary retinal nerve fibre layer (pRNFL), and higher intraocular pressure (IOP).
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