Ocular blood flow biomarkers may predict long-term glaucoma progression.
Verticchio Vercellin Alice Chandra, Harris Alon, Oddone Francesco, Siesky Brent, Eckert George, Belamkar Aditya, Antman Gal, Segev Fani
AI Summary
Studying glaucoma, researchers found lower baseline retinal capillary blood flow in the superior retina predicted structural progression over five years, suggesting it's a valuable prognostic biomarker.
Abstract
Background/aim: To examine the relationship between baseline blood flow biomarkers and long-term open-angle glaucoma (OAG) progression.
Methods
112 patients with early to moderate OAG (mean age 64.9±11.0 years; 68 female) were evaluated at baseline and every 6 months from 2008 to 2013. Biomarkers of retinal capillary blood flow were assessed by Heidelberg retinal flowmetry. Functional disease progression was monitored via Humphrey visual field examinations, defined as two consecutive visits with a mean deviation decrease ≥2 decibels and/or Advanced Glaucoma Intervention Study score increase ≥2 compared with baseline. Structural progression was monitored with optical coherence tomography and Heidelberg retinal tomograph, defined as two consecutive visits with retinal nerve fibre layer thickness decrease ≥8% and/or horizontal or vertical cup/disk ratio increase ≥0.2 compared with baseline. Mixed-model analysis of covariance was used to test for significant change from baseline to 5-year follow-up. Times to functional and structural progression were analysed using Cox proportional hazards models.
Results
Lower HRF retinal capillary blood flow in the superior retina was significantly associated with structural progression (p=0.0009).
Conclusion
In our OAG sample, baseline lower retinal capillary perfusion in the superior retina was predictive of structural progression after 5 years.
Trial registration number: NCT01145911.
MeSH Terms
Shields Classification
Key Concepts4
Lower Heidelberg Retinal Flowmetry (HRF) retinal capillary blood flow in the superior retina was significantly associated with structural progression of open-angle glaucoma (OAG) (p=0.0009) in a cohort study of 112 patients with early to moderate OAG.
Baseline lower retinal capillary perfusion in the superior retina was predictive of structural progression after 5 years in 112 patients with early to moderate open-angle glaucoma (OAG).
Functional disease progression in patients with open-angle glaucoma (OAG) was monitored via Humphrey visual field examinations, defined as two consecutive visits with a mean deviation decrease ≥2 decibels and/or Advanced Glaucoma Intervention Study score increase ≥2 compared with baseline, in a cohort study of 112 patients.
Structural progression in patients with open-angle glaucoma (OAG) was monitored with optical coherence tomography (OCT) and Heidelberg retinal tomograph (HRT), defined as two consecutive visits with retinal nerve fibre layer thickness decrease ≥8% and/or horizontal or vertical cup/disk ratio increase ≥0.2 compared with baseline, in a cohort study of 112 patients.
Related Articles5
Impact of Optic Nerve Tortuosity, Globe Proptosis, and Size on Retinal Ganglion Cell Thickness Across General, Glaucoma, and Myopic Populations.
Cohort StudySmoking Intensity is Associated With Progressive Optic Nerve Head Vessel Density Loss in Glaucoma.
Cohort StudyLamina Cribrosa Microstructure in Nonhuman Primates With Naturally Occurring Peripapillary Retinal Nerve Fiber Layer Thinning.
Observational StudyAssociation of Blood Pressure With Rates of Macular Ganglion Cell Complex Thinning in Patients With Glaucoma.
Cohort StudyAssociation of Postural Blood Pressure Response With Disease Severity in Primary Open Angle Glaucoma.
Observational StudyIs this article assigned to the wrong chapter(s)? Let us know.