Harris Alon

Ntonti Panagiota, Coleman Anne L, Wilson Masao Roy, Harris Alon, Papakonstantinou Evangelia, Giannoulis Dimitrios A et al.

This 12-year study identified high IOP, pseudoexfoliation, family history, and heart attack history as key risk factors for developing open-angle glaucoma, while increased sleep and alcohol were protective.

Ritzer Lukas, Harris Alon, Arciero Julia, Siesky Brent, Fry Brendan, Januleviciene Ingrida et al.

This study found that in early glaucoma, the link between retinal nerve fiber layer and blood vessel density is strongest in the optic nerve's temporal regions, suggesting temporal vessel loss could be an early disease marker.

Fry Brendan C, Arciero Julia C, Gyurek Croix, Albright Amanda, Siesky Brent, Verticchio Alice et al.

A theoretical model showed that reduced capillary density, impaired autoregulation, and high IOP decrease retinal oxygenation, particularly when combined. Early detection of these vascular changes is crucial to prevent glaucoma progression.

Vercellin Alice Verticchio, Pasquale Louis R, Harris Alon

Riina Nicholas, Harris Alon, Siesky Brent A, Ritzer Lukas, Pasquale Louis R, Tsai James C et al.

AI models found OCTA vascular biomarkers are as effective as OCT structural biomarkers for diagnosing primary open-angle glaucoma, offering new diagnostic avenues.

Verticchio Vercellin Alice Chandra, Harris Alon, Oddone Francesco, Siesky Brent, Eckert George, Belamkar Aditya et al.

Studying glaucoma, researchers found lower baseline retinal capillary blood flow in the superior retina predicted structural progression over five years, suggesting it's a valuable prognostic biomarker.

Harris Alon, Verticchio Vercellin Alice, Weinreb Robert N, Khawaja Anthony, MacGregor Stuart, Pasquale Louis R

The Glaucoma Think Tank highlighted how big data, AI, genetics, and lifestyle factors like caffeine/alcohol are crucial for understanding, preventing, and potentially reversing glaucoma vision loss.

Brown Aaron, Cousins Henry, Cousins Clara, Esquenazi Karina, Elze Tobias, Harris Alon et al.

This study developed deep learning for optic disc hemorrhage detection. An object detection AI accurately identified hemorrhages, performing comparably to expert clinicians, showing promise for automated glaucoma screening.

Tseng Victoria L, Topouzis Fotis, Yu Fei, Keskini Christina, Pappas Theofanis, Founti Panayiota et al.

Frequent salt intake was linked to increased open-angle glaucoma risk in individuals using antihypertensive medications. This suggests dietary salt may impact glaucoma, especially in treated hypertensive patients.

Siesky Brent, Harris Alon, Belamkar Aditya, Zukerman Ryan, Horn Avery, Verticchio Vercellin Alice et al.

This review highlights that glaucoma treatments like prostaglandin analogues and laser trabeculoplasty may be more effective in African-descent patients, while trabeculectomy may fail more often, emphasizing the need for tailored, prospective research.

Belamkar Aditya V, Jabbehdari Sayena, Harris Alon, Hajrasouliha Amir R

This review found RVO alters retinal oxygen saturation, with central RVO reducing venous saturation. Some drugs, like ranibizumab, may improve oxygenation, suggesting a therapeutic target, but more research is needed.

Founti Panayiota, Coleman Anne L, Wilson M Roy, Yu Fei, Harris Alon, Pappas Theofanis et al.

This study found a 12-year open-angle glaucoma incidence of 4.4% in elderly Whites, with pseudoexfoliative glaucoma showing a significantly higher incidence, highlighting its importance for screening.

Stoner Ari, Harris Alon, Oddone Francesco, Belamkar Aditya, Verticchio Vercellin Alice Chandra, Shin Joshua et al.

This review examined topical CAIs for glaucoma, finding they remain valuable combination therapy, potentially influencing ocular hemodynamics beyond pressure reduction, despite less frequent primary use.

Shin Joshua D, Wolf Amber T, Harris Alon, Verticchio Vercellin Alice, Siesky Brent, Rowe Lucas W et al.

OCTA shows glaucoma patients have significantly reduced retinal/optic nerve blood flow and vessel density, correlating with visual field loss. This may help assess glaucoma risk.

Harris Alon, Siesky Brent

Harris Alon, Siesky Brent

Shughoury Aumer, Mathew Sunu, Arciero Julia, Wurster Patrick, Adjei Susuana, Ciulla Thomas et al.

Retinal oximetry in glaucoma research investigates oxygen supply and demand. It shows promise for understanding glaucoma's causes, distinguishing primary vascular issues from secondary changes due to tissue atrophy.

Mathew Sunu, Harris Alon, Ridenour Colin M, Wirostko Barbara M, Burgett Kendall M, Scripture Molly D et al.

Verticchio Vercellin Alice C, Harris Alon, Tanga Lucia, Siesky Brent, Quaranta Luciano, Rowe Lucas W et al.

This study found optic nerve head vessel density variations throughout the day were small in healthy, OHT, and glaucoma patients, suggesting OCT-A can be performed anytime clinically.

Wurster Patrick, Harris Alon, Gonzalez Andrea C, Adjei Susuana, Verticchio Vercellin Alice, Mathew Sunu et al.

This review found open-angle glaucoma is a growing concern in Latin Americans, with unique risk factors like African ancestry and hypertension, necessitating targeted research for improved care.

Jasty Uma, Harris Alon, Siesky Brent, Rowe Lucas W, Verticchio Vercellin Alice C, Mathew Sunu et al.

This review found optic disc hemorrhage is a significant risk factor for primary open-angle glaucoma across populations, highlighting its importance for understanding glaucoma pathogenesis and treatment.

Ciulla Lauren, Moorthy Meena, Mathew Sunu, Siesky Brent, Verticchio Vercellin Alice C, Price David et al.

This review found nocturnal IOP peaks and BP troughs create low ocular perfusion, impacting glaucoma progression. Managing circadian rhythm and nocturnal IOP is key for treatment.

Price David A, Harris Alon, Siesky Brent, Mathew Sunu

This review found low intracranial pressure is often linked to glaucoma, but its exact relationship with retrolaminar tissue pressure varies based on optic canal size and lamina thickness, impacting disease understanding.

Harris Alon, Guidoboni Giovanna, Siesky Brent, Mathew Sunu, Verticchio Vercellin Alice C, Rowe Lucas et al.

Ocular blood flow impacts eye disease, but current assessment is limited. Integrating mathematical modeling and AI could enable personalized risk assessment and precision medicine in ophthalmology.

Dervenis Nikolaos, Harris Alon, Coleman Anne L, Wilson M Roy, Founti Panayiota, Yu Fei et al.

This study found older age, higher IOP, and taller height correlated with lower active retinal capillary density, while migraine was linked to higher density. These insights may help understand disease mechanisms.