Superficial macular vessel density in eyes with mild, moderate, and severe primary open-angle glaucoma.
Huo Yanjiao, Thomas Ravi, Guo Yan, Zhang Wei, Li Lei, Cao Kai, Wang Huaizhou, Wang Ningli
AI Summary
This study found macular microcirculation significantly declined in mild and severe glaucoma, but not between mild and moderate stages, linking it to age, visual field loss, and nerve thinning.
Abstract
Purpose
The aim of this study is to report changes in and associations of macular vessel density (VD) and perfusion density (PD) using optical coherence tomography angiography (OCTA) in mild, moderate, and severe open-angle glaucoma.
Methods
One hundred thirty-three patients with open-angle glaucoma (133 eyes: 47 mild, 33 moderate, and 53 severe glaucoma) and 73 normal subjects (right eyes) were included in this cross-sectional study. All subjects underwent Cirrus OCTA measurements. One-way analysis of variance (ANOVA) was used to compare macular VD and PD between the controls and mild, moderate, and severe glaucoma groups. Multiple linear regression was performed with OCTA parameters as the predicted variable and age, gender, spherical equivalent (SE), intraocular pressure (IOP), mean deviation (MD), signal strength (SS), and mean macular ganglion cell-inner plexiform layer (mGCIPL) thickness as the predictor variables.
Results
The total area of VD showed significant differences between the controls vs. mild (p < 0.001) and moderate vs. severe glaucoma (p = 0.003); no significant difference was found between mild and moderate glaucoma (p = 1.000). Macular VD was associated with age (β = -0.02, p = 0.003), MD (β = 0.04, p = 0.001), SS (β = 1.43, p < 0.001), and mGCIPL thickness (β = 0.04, p = 0.002) but not with gender, SE, and IOP (all p > 0.05).
Conclusions
Macular microcirculation declined significantly in mild and severe glaucoma. No significant difference was found between mild and moderate glaucoma. Decrease macular VD was independently associated with age, severe MD, lower SS, and thinner mGCIPL thickness.
MeSH Terms
Shields Classification
Key Concepts5
The total area of macular vessel density (VD) measured by Cirrus OCTA showed significant differences between controls and mild primary open-angle glaucoma (p < 0.001) and between moderate and severe primary open-angle glaucoma (p = 0.003).
No significant difference in the total area of macular vessel density (VD) measured by Cirrus OCTA was found between mild and moderate primary open-angle glaucoma (p = 1.000).
Macular vessel density (VD) in primary open-angle glaucoma was independently associated with age (β = -0.02, p = 0.003), mean deviation (MD) (β = 0.04, p = 0.001), signal strength (SS) (β = 1.43, p < 0.001), and mean macular ganglion cell-inner plexiform layer (mGCIPL) thickness (β = 0.04, p = 0.002).
Macular vessel density (VD) in primary open-angle glaucoma was not independently associated with gender, spherical equivalent (SE), and intraocular pressure (IOP) (all p > 0.05).
Macular microcirculation declined significantly in mild and severe primary open-angle glaucoma.
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