Locke Kirsten G

Bennett Lea D, Metz Georgiana, Klein Martin, Locke Kirsten G, Khwaja Areeba, Birch David G

This study found age and retinal region affect scotopic sensitivity, with specific repeatability for DAC perimetry in IRD and controls, crucial for monitoring disease progression.

Birch David G, Locke Kirsten G, Felius Joost, Klein Martin, Wheaton Dianna K H, Hoffman Dennis R et al.

XLRP patients with RPGR mutations show faster visual field decline (0.84-0.92 dB/year) at the ellipsoid zone edge than in the macula or mid-periphery (0.38-0.61 dB/year), marking a critical transition zone for monitoring disease progression.

Birch David G, Locke Kirsten G, Wen Yuquan, Locke Kelly I, Hoffman Dennis R, Hood Donald C

This study measured the inner segment ellipsoid zone (EZ) width in X-linked retinitis pigmentosa (XLRP) patients, finding a consistent annual decrease (7%). This makes EZ width a valid and sensitive outcome measure for future XLRP treatment trials.

Hood Donald C, Lazow Margot A, Locke Kirsten G, Greenstein Vivienne C, Birch David G

fdOCT revealed an orderly progression of retinal degeneration in RP, starting with outer segment thinning, then outer nuclear layer thinning, and ultimately complete loss, providing insights into disease progression.

Rangaswamy Nalini V, Patel Hemaxi M, Locke Kirsten G, Hood Donald C, Birch David G

In Retinitis Pigmentosa, photoreceptor outer segment and outer nuclear layer thickness decrease linearly with visual field sensitivity loss, indicating structural damage correlates with functional decline.

Hood Donald C, Lin Christine E, Lazow Margot A, Locke Kirsten G, Zhang Xian, Birch David G

fdOCT showed RP patients have significantly thicker retinal nerve fiber layers, but normal RGC layers. This suggests RNFL thickness may not accurately reflect RGC integrity in RP.