McLaren J W

Brubaker R F, Bourne W M, Bachman L A, McLaren J W

Human corneal epithelium contains high ascorbic acid levels, 14 times that of aqueous humor, suggesting it protects the cornea's basal layer from UV radiation.

Peterson J A, Tian B, McLaren J W, Hubbard W C, Geiger B, Kaufman P L

Latrunculins A and B lowered eye pressure by increasing fluid outflow, suggesting a new glaucoma treatment, but caused corneal side effects that raise safety concerns.

Bourne W M, Hodge D O, McLaren J W

Long-term contact lens wear was studied for its effect on corneal endothelial pump function. Despite morphological changes, no significant impact on endothelial pump function was found, suggesting good functional resilience.

Egan C A, Hodge D O, McLaren J W, Bourne W M

Dorzolamide eye drops increased corneal endothelial permeability to fluorescein in normal eyes, but did not impair corneal deswelling or thickness. This suggests a subtle, likely non-clinical, endothelial effect.

McLaren J W, Brubaker R F, FitzSimon J S

Researchers implanted telemetric sensors in rabbits to continuously measure IOP, revealing significant circadian rhythms in IOP that adapt to light changes, offering a new tool for glaucoma research.

McLaren J W, Trocme S D, Relf S, Brubaker R F

This study measured aqueous humor flow using flare, finding significant diurnal variations in both rabbits and humans, with flow decreasing during sleep/dark periods. This impacts glaucoma treatment timing.

Carlson K H, McLaren J W, Topper J E, Brubaker R F

Studying body position's effect on IOP and aqueous flow, researchers found aqueous humor formation is largely insensitive to IOP changes, suggesting IOP doesn't significantly regulate aqueous production.

Brubaker R F, McLaren J W

Fluorophotometry measures aqueous humor flow in glaucoma patients and healthy individuals, aiding in understanding disease and drug effects, with calculation tables provided for clinical use.