Topper J E

Carlson K H, McLaren J W, Topper J E, Brubaker R F

Studying body position's effect on IOP and aqueous flow, researchers found aqueous humor formation is largely insensitive to IOP changes, suggesting IOP doesn't significantly regulate aqueous production.

Topper J E, Brubaker R F

This study found timolol reduced aqueous flow in awake subjects, while epinephrine increased it more during sleep, suggesting endogenous epinephrine drives diurnal aqueous humor flow variations.

Reiss G R, Lee D A, Topper J E, Brubaker R F

Aqueous humor flow significantly decreases during sleep (mean 45%), even more than when awake at night, a reduction comparable to glaucoma medications.