O'Neill Nuala

🇴🇲 Penn Presbyterian Medical Center

OpenAlex2 articles in GJC

2 articles in GJC

Comparison of SNCG and NEFH Promoter-Driven Expression of Human SIRT1 Expression in a Mouse Model of Glaucoma.

O'Neill Nuala, Meng Miranda, Chaqour Brahim, Dine Kimberly, Sarabu Neha, Pham Jennifer C et al.

Transl Vis Sci TechnolAug 20244 citationsBasic Science

Researchers found that smaller NEFH and SNCG promoters equally drive neuroprotective gene delivery to retinal ganglion cells in a glaucoma mouse model, improving RGC survival and vision. This allows for packaging larger therapeutic genes.

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Comparison of Brn3a and RBPMS Labeling to Assess Retinal Ganglion Cell Loss During Aging and in a Model of Optic Neuropathy.

Meng Miranda, Chaqour Brahim, O'Neill Nuala, Dine Kimberly, Sarabu Neha, Ying Gui-Shuang et al.

Invest Ophthalmol Vis SciApr 20249 citationsBasic Science

This study compared Brn3a and RBPMS markers for counting retinal ganglion cells (RGCs). Both detect RGC loss in aging and optic neuropathy, but Brn3a offers more consistent manual counts, aiding glaucoma research.

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O'Neill Nuala

Comparison of SNCG and NEFH Promoter-Driven Expression of Human SIRT1 Expression in a Mouse Model of Glaucoma.

Comparison of Brn3a and RBPMS Labeling to Assess Retinal Ganglion Cell Loss During Aging and in a Model of Optic Neuropathy.