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Melanopsin is expressed in PACAP-containing retinal ganglion cells of the human retinohypothalamic tract.
Hannibal Jens, Hindersson Peter, Ostergaard Jens, Georg Birgitte, Heegaard Steffen, Larsen Philip Just et al.
Invest Ophthalmol Vis SciNov 2004152 citationsBasic Science
This study found melanopsin in human RGCs co-localized with PACAP, forming the RHT and persisting in blind eyes. This suggests melanopsin is crucial for non-visual light perception and circadian rhythms in both sighted and blind individuals.