Samples John R

Samples John R, Singh Kuldev, Lin Shan C, Francis Brian A, Hodapp Elizabeth, Jampel Henry D et al.

Laser trabeculoplasty effectively lowers intraocular pressure in open-angle glaucoma, with acceptable long-term efficacy comparable to initial medical treatment, making it a viable therapeutic option.

Francis Brian A, Singh Kuldev, Lin Shan C, Hodapp Elizabeth, Jampel Henry D, Samples John R et al.

This review of novel glaucoma surgeries found all studied procedures significantly lowered intraocular pressure, showing promise as alternative treatments, but more comparative research is needed for clinical superiority.

Jampel Henry D, Singh Kuldev, Lin Shan C, Chen Teresa C, Francis Brian A, Hodapp Elizabeth et al.

This review found standard perimetry is key for glaucoma assessment, but despite advances, no single test definitively guides diagnosis or progression, highlighting the need for objective measures.

Charlesworth Jac, Kramer Patricia L, Dyer Tom, Diego Victor, Samples John R, Craig Jamie E et al.

This study found intraocular pressure and cup-to-disc ratio are strongly genetically linked to open-angle glaucoma, making them valuable traits for finding glaucoma genes, unlike central corneal thickness.

Wirtz Mary K, Samples John R, Toumanidou Victoria, Charlesworth Jac, Mikropoulos Dimitrios G, Kaltsos Konstantinos et al.

In an isolated Greek population, the Thr377Met MYOC mutation was strongly linked to higher intraocular pressure and optic nerve damage (VCDR), highlighting its role in glaucoma severity.

Minckler Don S, Francis Brian A, Hodapp Elizabeth A, Jampel Henry D, Lin Shan C, Samples John R et al.

This review found aqueous shunts effectively control IOP in complex glaucoma, comparable to trabeculectomy, with corneal endothelial failure and erosion as key complications, making them a viable option for refractory cases.

Dueker David K, Singh Kuldev, Lin Shan C, Fechtner Robert D, Minckler Don S, Samples John R et al.

This study found central corneal thickness (CCT) is a strong risk factor for ocular hypertension progressing to glaucoma. CCT measurement is crucial for evaluating glaucoma risk, especially in ocular hypertension patients, due to its impact on IOP readings.

Wirtz Mary K, Samples John R, Choi Dongseok, Gaudette N Donna

A study of a US family with the Asp380His myocilin mutation found it causes severe primary open-angle glaucoma with extremely high IOPs, an intermediate phenotype between juvenile and adult onset.

Flaxel Christina J, Samples John R, Dustin Laurie

This study found Humphrey VF foveal threshold reliably correlates with best-corrected visual acuity, suggesting it can estimate vision and detect nonorganic visual loss.

Eisner Alvin, Toomey Maureen D, Incognito Lisa J, O'malley Jean P, Samples John R

This study found blue-on-yellow visual field differences are largely due to individual adaptation to the yellow background and pupil size, suggesting consistent pupil status is crucial for clinical monitoring.

Petersen Michael B, Kitsos George, Samples John R, Gaudette N Donna, Economou-Petersen Effrosini, Sykes Renée et al.

This study found a MYOC T377M mutation in a Greek glaucoma family previously linked to GLC1C. Carriers of both genes had earlier, more severe glaucoma, suggesting gene interaction or cumulative risk.

Westfall Andrew C, Ng John D, Samples John R, Weissman Jane L

MRI of a glaucoma patient with hypotonus maculopathy revealed macular thickening and posterior globe flattening. This unique imaging finding helps characterize this rare, vision-threatening complication.

Gray Andrea V, Michels Kevin S, Lauer Andreas Katsuya, Samples John R

*Bartonella henselae* infection was linked to a case of central retinal artery/vein occlusion, neovascular glaucoma, and severe vision loss. This highlights a rare but devastating ocular complication of cat scratch disease.

Wirtz Mary K, Samples John R, Xu Hong, Severson Tesa, Acott Ted S

This study mapped genes expressed in infant human trabecular meshwork, identifying abundant genes and 13 novel ones. This gene profile and chromosomal data are crucial for finding glaucoma-causing genes.