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Profiling IOP-Responsive Genes in the Trabecular Meshwork and Optic Nerve Head in a Rat Model of Controlled Elevation of Intraocular Pressure.
Lozano Diana C, Yang Yong-Feng, Cepurna William O, Smoody Barbara F, Ing Eliesa, Morrison John C et al.
Invest Ophthalmol Vis SciMay 20244 citationsBasic Science
This rat study found elevated IOP alters gene expression in the trabecular meshwork (TGFβ pathway downregulated) and optic nerve head (immune/defense pathways upregulated), suggesting distinct tissue responses to pressure that may impact glaucoma.