Song Maomao

Hu Chunchun, Niu Liangliang, Li Liping, Song Maomao, Zhang Youjia, Lei Yuan et al.

ABCA1 regulates eye pressure by modulating the Cav1/eNOS/NO pathway, and its activation improved outflow facility. This mechanism presents ABCA1 as a novel therapeutic target for glaucoma.

Song Maomao, Li Liping, Lei Yuan, Sun Xinghuai

Studying NOS3/Cav1 double knockout mice, researchers found reduced eye pressure sensitivity to NO-modulating drugs, suggesting compromised NO signaling affects glaucoma treatment response.

Song Maomao, Wu Jihong, Lei Yuan, Sun Xinghuai

Deleting NOS3 in CAV1-deficient mice restored normal aqueous humor outflow and eye pressure. This suggests NOS3 and CAV1 interaction is crucial for IOP regulation, offering a potential glaucoma treatment target.

Lei Yuan, Song Maomao, Wu Jihong, Xing Chao, Sun Xinghuai

CAV1 knockout mice with high IOP and low outflow showed increased eNOS activity. NO donors improved outflow, suggesting targeting NO pathways could treat glaucoma.

Lei Yuan, Zhang Xuejin, Song Maomao, Wu Jihong, Sun Xinghuai

NOS3 gene knockout mice had elevated IOP and reduced outflow, suggesting eNOS is crucial for normal outflow. This supports human data linking NOS3 polymorphisms to ocular hypertension and glaucoma.