Wu Jihong

Zhao Yingke, Wu Jiawen, Li Chenchen, Cheng Yun, Li Qian, Wu Jianing et al.

136 proteins linked to glaucoma, with 4 causal (LTBP2, NRP2, TNFSF13, HAVCR1) detectable 12-15 years pre-diagnosis. This offers early risk stratification, targeted screening, and therapeutic targets for glaucoma.

Zhang Xuejin, Li Ting, Zhang Rong, Li Junfeng, Wang Kaidi, Wu Jihong

Studying glaucoma models, researchers found SARM1 downregulation protected retinal ganglion cells and their axons via JNK, suggesting a potential therapeutic target.

Yuan Nini, Li Mengwei, Chen Xiaoxiao, Lu Yiliang, Fang Yuan, Gong Hongliang et al.

Acute IOP elevation (≥50 mmHg) in cats suppressed cortical motion processing, particularly fine discrimination in central vision. This suggests acute glaucoma impacts specific visual pathways, explaining immediate visual deficits.

Zhang Xuejin, Zhang Rong, Zhou Xujiao, Wu Jihong

This study found elevated d-Serine in glaucomatous eyes. Reducing d-Serine levels protected retinal ganglion cells, suggesting it's a potential therapeutic target for glaucoma neuroprotection.

Song Maomao, Wu Jihong, Lei Yuan, Sun Xinghuai

Deleting NOS3 in CAV1-deficient mice restored normal aqueous humor outflow and eye pressure. This suggests NOS3 and CAV1 interaction is crucial for IOP regulation, offering a potential glaucoma treatment target.

Lei Yuan, Song Maomao, Wu Jihong, Xing Chao, Sun Xinghuai

CAV1 knockout mice with high IOP and low outflow showed increased eNOS activity. NO donors improved outflow, suggesting targeting NO pathways could treat glaucoma.

Lei Yuan, Zhang Xuejin, Song Maomao, Wu Jihong, Sun Xinghuai

NOS3 gene knockout mice had elevated IOP and reduced outflow, suggesting eNOS is crucial for normal outflow. This supports human data linking NOS3 polymorphisms to ocular hypertension and glaucoma.

Lei Yuan, Stamer William D, Wu Jihong, Sun Xinghuai

This study found chronic oxidative stress on Schlemm's canal cells decreases permeability, suggesting aging-related oxidative stress may increase outflow resistance in glaucoma.

Huang Haili, Jonas Jost B, Dai Yi, Hong Jiaxu, Wang Min, Chen Junyi et al.

This study found that in advanced glaucoma, a central visual field island is associated with a more temporally located central retinal vessel trunk, suggesting CRVT position may influence visual field loss patterns.

Wu Jihong, Zhang Shenghai, Sun Xinghuai

This study found that Sonic Hedgehog (Shh) is upregulated and protects retinal ganglion cells in a rat glaucoma model, suggesting it's a potential neuroprotective therapy.