Sugita Sunao

Nakano Satoko, Tomaru Yasuhiro, Kubota Toshiaki, Takase Hiroshi, Mochizuki Manabu, Shimizu Norio et al.

This new rapid, DNA-extraction-free PCR test for uveitis pathogens showed high accuracy and speed, enabling quicker diagnosis and intraoperative use, potentially improving infectious uveitis outcomes.

Nakano Satoko, Tomaru Yasuhiro, Kubota Toshiaki, Takase Hiroshi, Mochizuki Manabu, Shimizu Norio et al.

This study evaluated a new multiplex PCR test for infectious uveitis, finding it accurate, easy to use, and comparable to conventional methods, making it a valuable tool for rapid diagnosis.

Miyazaki Dai, Shimizu Daisuke, Shimizu Yumiko, Inoue Yoshitsugu, Inoue Tomoyuki, Higaki Shiro et al.

Standardized qPCR accurately diagnoses ocular CMV, especially CMV retinitis. Combining qPCR with clinical features like recurrences and IOP elevation further improves diagnostic efficacy for various ocular CMV diseases.

Nakano Satoko, Sugita Sunao, Tomaru Yasuhiro, Hono Ayumi, Nakamuro Takako, Kubota Toshiaki et al.

This study developed a strip PCR test that rapidly and sensitively detects 18 common ocular infection pathogens, offering a quick diagnostic tool for ophthalmologists.

Ogawa Manabu, Sugita Sunao, Watanabe Ken, Shimizu Norio, Mochizuki Manabu

A novel PCR test for fungal DNA in eye fluids accurately diagnosed fungal endophthalmitis in most cases, offering a useful tool for rapid detection and guiding treatment.

Sugita Sunao, Shimizu Norio, Watanabe Ken, Ogawa Manabu, Maruyama Kazuichi, Usui Norio et al.

HHV-6 DNA was found in 2% of ocular inflammatory cases, with mRNA in one, suggesting HHV-6 infection/reactivation can cause specific ocular inflammation, informing diagnosis and treatment.

Sugita Sunao, Kamoi Koju, Ogawa Manabu, Watanabe Ken, Shimizu Norio, Mochizuki Manabu

This study developed a broad-range PCR detecting Candida/Aspergillus DNA in 13% of unknown uveitis/endophthalmitis cases, offering a rapid diagnostic tool for fungal endophthalmitis.

Miyanaga Masaru, Sugita Sunao, Shimizu Norio, Morio Tomohiro, Miyata Kazunori, Maruyama Kazuichi et al.

This study found higher CMV viral loads in aqueous humor correlated with increased corneal endothelial cell damage in patients with CMV anterior uveitis, highlighting viral load's impact on corneal health.

Sugita Sunao, Takase Hiroshi, Taguchi Chikako, Mochizuki Manabu

This study found soluble TNF receptors (sTNF-Rs) are elevated in active uveitis, and surprisingly, they enhance intraocular TNF-alpha production, suggesting a regulatory role in ocular inflammation.

Sugita Sunao, Takase Hiroshi, Taguchi Chikako, Imai Yasuhisa, Kamoi Koju, Kawaguchi Tatsushi et al.

Ocular T cells in VKH patients recognize melanocyte antigens, like tyrosinase and gp100, driving inflammation. This suggests these T cells contribute to VKH disease pathology, potentially triggered by molecular mimicry with viruses.

Takase Hiroshi, Futagami Yuri, Yoshida Tomoko, Kamoi Koju, Sugita Sunao, Imai Yasuhisa et al.

This study found IFN-gamma is the most abundant aqueous humor cytokine in both infectious and noninfectious uveitis, suggesting its role in ocular inflammation and potential diagnostic utility.

Takase Hiroshi, Sugita Sunao, Rhee Douglas J, Imai Yasuhisa, Taguchi Chikako, Sugamoto Yoshiharu et al.

MIF is expressed and secreted by trabecular meshwork cells, enhancing T helper 1 cytokines. This suggests MIF may drive ocular inflammation, offering a potential therapeutic target for glaucoma.