Tamm E R

Maihöfner C, Schlötzer-Schrehardt U, Gühring H, Zeilhofer H U, Naumann G O, Pahl A et al.

This study found that primary open-angle glaucoma involves a specific loss of COX-2 enzyme in the ciliary body, suggesting a role in disease development and potential therapeutic targets.

Tamm E R, Polansky J R

Tamm E R, Russell P

A meeting reviewed myocilin's role in glaucoma, exploring how mutations affect its protein function. Understanding these mechanisms is crucial for future glaucoma research and treatment.

Russell P, Tamm E R, Grehn F J, Picht G, Johnson M

Myocilin was found in aqueous humor, appearing as a large, hydrophobic protein that can obstruct filters, suggesting its role in outflow pathway resistance in glaucoma.

Tamm E R, Russell P, Epstein D L, Johnson D H, Piatigorsky J

This study found myocilin/TIGR expression in human TM is maintained by mechanical stimuli and significantly increased by dexamethasone, TGF-beta1, and stretch, which is relevant to glaucoma pathophysiology.

Tamm E R, Russell P, Piatigorsky J

Researchers developed a mouse trabecular meshwork cell line (MUTM-NEI/1) that differentiates at body temperature. This immortalized cell line provides a valuable tool for studying glaucoma mechanisms and gene expression.

Tamm E R, Russell P, Johnson D H, Piatigorsky J

This study found trabecular meshwork cells increase protective alpha B-crystallin under stress, suggesting it's a key defense mechanism against glaucoma-related damage.

Borrás T, Tamm E R, Zigler J S

Adenoviral gene transfer to the anterior eye varies by tissue, showing promise but causing significant inflammation and cell damage in some areas, highlighting safety concerns for glaucoma gene therapy.