Schlötzer-Schrehardt U

Hübner Lisa, Schlötzer-Schrehardt U, Weller J M, Hohberger B, Mardin C Y, Lämmer R

Explanted CyPass microstents revealed fibrotic tissue, particularly in pseudoexfoliation glaucoma, causing stent failure. This highlights fibrosis as a key mechanism for MIGS failure, informing future device design.

Terai N, Schlötzer-Schrehardt U, Lampel J, Böhm A G, Rummelt C, Schmidt E et al.

Latanoprost-treated glaucoma patients showed decreased conjunctival collagen and less inflammation/matrix accumulation than timolol, suggesting latanoprost may improve glaucoma surgery outcomes.

Koliakos G G, Konstas A G P, Schlötzer-Schrehardt U, Hollo G, Mitova D, Kovatchev D et al.

This study found increased Endothelin-1 in aqueous humor of exfoliation syndrome patients, suggesting its role in XFS pathobiology, potentially impacting its progressive iris vasculopathy and glaucoma risk.

Maihöfner C, Schlötzer-Schrehardt U, Gühring H, Zeilhofer H U, Naumann G O, Pahl A et al.

This study found that primary open-angle glaucoma involves a specific loss of COX-2 enzyme in the ciliary body, suggesting a role in disease development and potential therapeutic targets.

Berlau J, Lorenz P, Beck R, Makovitzky J, Schlötzer-Schrehardt U, Thiesen H J et al.

This study found pseudoexfoliation syndrome eyes didn't have higher total aqueous protein or unique protein bands, but exclusively contained amyloid. This suggests PEX is linked to serum protein amyloid.

Mietz H, Schlötzer-Schrehardt U, Strassfeld C, Krieglstein G K

Rabbit study found timolol increased conjunctival collagen and degenerative changes, unlike latanoprost which upregulated MMP-3. This suggests timolol-induced changes could impair glaucoma surgery outcomes.

Ritch R, Schlötzer-Schrehardt U

Exfoliation syndrome (XFS) is an age-related ocular disease causing abnormal material accumulation. It's the most common identifiable cause of glaucoma, leading to worse prognosis and increased surgical risks, necessitating early detection.

Cursiefen C, Holbach L M, Schlötzer-Schrehardt U, Naumann G O

Blind, atrophic human eyes often retain a significant number of retinal ganglion cell axons. This finding suggests potential for future visual prostheses by stimulating these surviving nerve fibers.

Naumann G O, Schlötzer-Schrehardt U, Küchle M

This review highlights that pseudoexfoliation syndrome is a generalized disorder causing diverse ocular complications, including glaucoma, zonular weakness, and corneal issues. Recognizing these risks is crucial for all ophthalmologists, especially perioperatively.

Schlötzer-Schrehardt U, von der Mark K, Sakai L Y, Naumann G O

This study found increased fibrillin-containing fibrils in pseudoexfoliation syndrome eyes, suggesting fibrillin's enhanced expression or abnormal aggregation contributes to the disease's pathogenesis.

Asano N, Schlötzer-Schrehardt U, Naumann G O

This study found pseudoexfoliation fibers widely infiltrate iris cells, causing degenerative changes, particularly in muscle cells. This explains poor pupil dilation and iris atrophy in pseudoexfoliation syndrome.

Schlötzer-Schrehardt U, Naumann G O

This study found glaucoma in PEX syndrome is linked to increased PEX material, especially locally produced in the JCT, causing outflow dysfunction, not melanin or plaque.