Krieglstein G K

Rosentreter A, Schild A M, Jordan J F, Krieglstein G K, Dietlein T S

This study compared Ologen vs. MMC in glaucoma surgery. MMC achieved better IOP reduction and success rates than Ologen, despite Ologen possibly yielding healthier blebs. MMC remains superior for IOP control.

Dietlein T S, Jordan J, Lueke C, Krieglstein G K

This review found established efficacy and safety for traditional glaucoma drainage devices, while newer implants targeting alternative outflow routes lack long-term clinical trial data.

Joussen A M, Walter P, Jonescu-Cuypers C P, Koizumi K, Poulaki V, Bartz-Schmidt K U et al.

Retinectomy effectively lowered intraocular pressure long-term in many intractable glaucoma cases, but had significant complications (e.g., retinal detachment, phthisis), with variable success depending on the underlying glaucoma type.

Jordan J F, Diestelhorst M, Grisanti S, Krieglstein G K

This pilot study found photodynamic therapy with BCECF-AM during trabeculectomy was safe and effectively lowered IOP in 59.5% of patients, suggesting potential to improve glaucoma surgery outcomes.

Lüke C, Dietlein T S, Jacobi P C, Konen W, Krieglstein G K

This study found adding a hyaluronic acid implant to viscocanalostomy for glaucoma offered no IOP or success rate advantage over standard surgery over one year, with comparable low complication rates.

Dietlein T S, Engels B F, Jacobi P C, Krieglstein G K

This study showed ultrasound biomicroscopy (UBM) can guide angle surgery in pig eyes, visualizing instruments and tissue contact. This could offer real-time intraoperative control for glaucoma procedures.

Roters S, Lüke C, Jonescu-Cuypers C P, Engels B F, Jacobi P C, Konen W et al.

Early UBM findings after viscocanalostomy, like a visible outflow route or trabeculocorneal membrane thickness, predict long-term IOP control, suggesting UBM guides prognosis.

Mietz H, Andresen A, Welsandt G, Krieglstein G K

Cataract surgery after trabeculectomy generally maintains good IOP control, especially in initially well-controlled eyes, and offers potential IOP improvement for those with prior qualified success or failure.

Krieglstein G K

Mietz H, Schlötzer-Schrehardt U, Strassfeld C, Krieglstein G K

Rabbit study found timolol increased conjunctival collagen and degenerative changes, unlike latanoprost which upregulated MMP-3. This suggests timolol-induced changes could impair glaucoma surgery outcomes.

Dietlein T S, Jacobi P C, Lüke C, Krieglstein G K

This study found trabecular meshwork thickness and pigmentation vary significantly in glaucoma patients. Older, white patients have thinner anterior meshwork and less pigment, increasing deep sclerectomy perforation risk and potentially limiting surgical success.

Mietz H, Aisenbrey S, Ulrich Bartz-Schmidt K, Bamborschke S, Krieglstein G K

Ganciclovir effectively reduced inflammation and normalized IOP in an immunocompetent patient with CMV uveitis and secondary glaucoma, suggesting continuous treatment may be needed.

Esser J, Esser P, Mietz H, Hueber A, Kociok N, Schraermeyer U et al.

This study found multidrug resistance proteins (MRP/LRP) in glaucoma patients' Tenon's tissue. Their presence suggests these proteins may counteract chemotherapy drugs used in glaucoma surgery, impacting treatment effectiveness.

Jacobi P C, Dietlein T S, Krieglstein G K

This study found trabecular aspiration with cataract surgery for exfoliation glaucoma is less effective at lowering IOP than trabeculectomy but has a better safety profile, making it a potential alternative.

Dietlein T S, Engels B F, Jacobi P C, Krieglstein G K

UBM identifies prior congenital glaucoma surgeries, aiding surgical planning, but its correlation with surgical success in children is limited, unlike in adults.

Jacobi P C, Dietlein T S, Krieglstein G K

This review explores new ab interno trabecular surgeries, finding promising results in selectively treating diseased trabecular meshwork to reduce glaucoma risks, though some methods are still experimental.

Dietlein T S, Lüke C, Jacobi P C, Konen W, Krieglstein G K

Deep sclerectomy depth varies significantly, even by experienced surgeons, often including Schlemm's canal tissue not always apparent intraoperatively. This morphological variability likely impacts surgical outcomes.

Jacobi P C, Dietlein T S, Krieglstein G K

Trabecular aspiration for pigmentary glaucoma and pigment dispersion syndrome showed poor long-term IOP control, though PDS responded better. This suggests limited clinical utility for this procedure.

Bartz-Schmidt K U, Thumann G, Psichias A, Krieglstein G K, Heimann K

This study found intense antiproliferative surgery (vitrectomy, panretinal/ciliary body laser, silicone oil) effectively lowered intraocular pressure in many patients with uncontrolled neovascular glaucoma, offering a viable treatment option.

Bartz-Schmidt K U, Thumann G, Jonescu-Cuypers C P, Krieglstein G K

This study found that significant optic nerve damage (40% rim loss) occurs before visual field defects appear in early glaucoma, highlighting morphology's importance for early detection and follow-up.

Theofylaktopoulos I, Diestelhorst M, Krieglstein G K

This study found a new self-tonometer (Ocuton S) had low patient success and significantly overestimated IOP compared to Goldmann, indicating it needs refinement before home use.

Mietz H, Raschka B, Krieglstein G K

This study found that trabeculectomy without antimetabolites succeeded in primary open-angle and pseudoexfoliation glaucoma, but failed often in complex types like neovascular or uveitic glaucoma.

Schraermeyer U, Diestelhorst M, Bieker A, Theisohn M, Mietz H, Ustundag C et al.

This study found that MMC applied via collagen shield or contact lens caused severe ciliary body damage in rabbits, suggesting safer delivery methods are needed to prevent hypotony in glaucoma surgery.

Jacobi P C, Dietlein T S, Krieglstein G K

Goniocurettage, a new surgical technique, effectively lowered eye pressure in 60% of advanced glaucoma patients with failed prior surgeries, offering a viable alternative for scarred eyes.

Krieglstein G K