Mietz H

Mietz H, Andresen A, Welsandt G, Krieglstein G K

Cataract surgery after trabeculectomy generally maintains good IOP control, especially in initially well-controlled eyes, and offers potential IOP improvement for those with prior qualified success or failure.

Mietz H, Schlötzer-Schrehardt U, Strassfeld C, Krieglstein G K

Rabbit study found timolol increased conjunctival collagen and degenerative changes, unlike latanoprost which upregulated MMP-3. This suggests timolol-induced changes could impair glaucoma surgery outcomes.

Mietz H, Aisenbrey S, Ulrich Bartz-Schmidt K, Bamborschke S, Krieglstein G K

Ganciclovir effectively reduced inflammation and normalized IOP in an immunocompetent patient with CMV uveitis and secondary glaucoma, suggesting continuous treatment may be needed.

Esser J, Esser P, Mietz H, Hueber A, Kociok N, Schraermeyer U et al.

This study found multidrug resistance proteins (MRP/LRP) in glaucoma patients' Tenon's tissue. Their presence suggests these proteins may counteract chemotherapy drugs used in glaucoma surgery, impacting treatment effectiveness.

El-Harazi S M, Feldman R M, Villanueva G, Carter-Dawson L, Mietz H, Chuang A Z

This rabbit study found lower-dose, multiple postoperative MMC applications for trabeculectomy were as effective as higher-dose intraoperative MMC, but caused less ciliary toxicity, suggesting a safer regimen for glaucoma surgery.

Mietz H, Raschka B, Krieglstein G K

This study found that trabeculectomy without antimetabolites succeeded in primary open-angle and pseudoexfoliation glaucoma, but failed often in complex types like neovascular or uveitic glaucoma.

Schraermeyer U, Diestelhorst M, Bieker A, Theisohn M, Mietz H, Ustundag C et al.

This study found that MMC applied via collagen shield or contact lens caused severe ciliary body damage in rabbits, suggesting safer delivery methods are needed to prevent hypotony in glaucoma surgery.

Mietz H, Chévez-Barrios P, Feldman R M, Lieberman M W

Suramin, tested in rabbits, effectively inhibited scarring after glaucoma surgery, outperforming mitomycin C with fewer toxic effects, suggesting a new approach to improve surgical outcomes.

Mietz H, Chévez-Barrios P, Lieberman M W

This mouse model of glaucoma surgery wound healing identified PDGF A, TGF beta 1/2 as early targets, and found suramin modulates healing, offering potential for improving surgical outcomes.

Dietlein T S, Mietz H, Jacobi P C, Krieglstein G K

This study found spherophakia and nanophthalmia in brachydactyly-associated syndromes, not just Marchesani's. Hypoplastic ciliary bodies were noted, and glaucoma surgery in these eyes carried a high risk of complications.

Mietz H, Arnold G, Kirchhof B, Diestelhorst M, Krieglstein G K

Failed trabeculectomies showed distinct scarring: without MMC, dense, contractile tissue; with MMC, less dense, non-contractile tissue. This highlights MMC's long-term scar-modifying effect, though failures still occur.

Mietz H

Mitomycin C used in glaucoma surgery can cause ciliary body toxicity, reducing aqueous humor production and contributing to postoperative hypotony, impacting intraocular pressure control.

Mietz H, Niesen U, Krieglstein G K

This study found glaucoma medication preservatives worsen conjunctival collagen changes, suggesting they contribute to adverse ocular surface effects beyond the drugs themselves.