Thanos Solon

Liu Hanhan, Bell Katharina, Herrmann Anja, Arnhold Stefan, Mercieca Karl, Anders Fabian et al.

This study found that crystallins (CRYAB, CRYBB2, CRYGB) decrease with age-related glaucoma, and their supplementation protects retinal ganglion cells by stimulating Müller cells to secrete neurotrophic factors.

Brockhaus Katrin, Melkonyan Harutyun, Prokosch-Willing Verena, Liu Hanhan, Thanos Solon

Mouse retinal explants under elevated pressure showed altered junction proteins and signaling, mimicking glaucoma-related changes. This suggests pressure-induced blood-retina barrier disruption and cell signaling contribute to glaucoma.

Prokosch Verena, Brockhaus Kathrin, Anders Fabian, Liu Hanhan, Mercieca Karl, Gericke Adrian et al.

Elevated IOP in glaucoma models causes neuron-specific β-III-tubulin expression in retinal vascular cells (pericytes, endothelial cells). This suggests vascular cells play a direct role in glaucoma's neurodegeneration, beyond just RGC loss.

Liu Hanhan, Anders Fabian, Thanos Solon, Mann Carolina, Liu Aiwei, Grus Franz H et al.

Hydrogen sulfide (H2S) protected retinal ganglion cells in experimental glaucoma models by reducing stress and dilating vessels, suggesting it's a promising neuroprotective treatment for glaucoma.

Böhm Michael R. R., Hodes Florian, Brockhaus Katrin, Hummel Stephanie, Schlatt Stefan, Melkonyan Harutyun et al.

This study found retinal ganglion cells express angiostatin, while blood vessels have its receptor, suggesting angiostatin helps maintain the foveal avascular zone.

Böhm Michael R R, Pfrommer Sarah, Chiwitt Carolin, Brückner Matthias, Melkonyan Harutyun, Thanos Solon

Crybb2-overexpressing progenitor cells protected retinal ganglion cells and photoreceptors after optic nerve injury in rats, suggesting a novel cell-based therapy for degenerative retinal diseases.

Prokosch Verena, Panagis Lambros, Volk Gerd Fabian, Dermon Caterina, Thanos Solon

This study found α2-receptors increase in injured retinas. Brimonidine promoted axonal growth in juvenile, glaucomatous, and injured retinal explants, suggesting α2-receptors are crucial for retinal neuroprotection and repair.

Feigenspan Andreas, Dedek Karin, Schlich Katrin, Weiler Reto, Thanos Solon

This study found regenerating optic nerve growth cones express NaV channels, generating single action potentials, unlike ganglion cell bodies. This difference may impact optic nerve regeneration strategies.

Biermann Julia, Grieshaber Philippe, Goebel Ulrich, Martin Gottfried, Thanos Solon, Di Giovanni Simone et al.

Valproic acid protected retinal ganglion cells and promoted axon regeneration after optic nerve injury in rats, suggesting a potential neuroprotective treatment for glaucoma and optic neuropathies.

Charalambous Petar, Hurst Louise A, Thanos Solon

Chicken neural tube stem cells transplanted into injured rat optic nerves promoted significant axonal regeneration by degrading inhibitory molecules and providing growth factors. This offers a promising strategy for optic nerve repair.

Meyer-Rüsenberg Birthe, Pavlidis Mitrofanis, Stupp Tobias, Thanos Solon

This study found diabetic and hypertensive retinopathy cause similar retinal ganglion cell damage, including axon swelling and reduced dendritic fields, highlighting neuronal impact beyond vascular changes.

Heiduschka Peter, Thanos Solon

Cortisol improved retinal ganglion cell survival and regeneration after optic nerve injury in rats, and significantly enhanced effects when combined with aurintricarboxylic acid, suggesting a potential neuroprotective glaucoma therapy.

Pavlidis Mitrofanis, Stupp Tobias, Hummeke Markus, Thanos Solon

This study found human and monkey papillomacular area/bundle mainly contain small midget retinal ganglion cells with unique, atypically oriented dendrites. This distinct morphology is relevant for understanding central vision and glaucoma.

Pavlidis Mitrofanis, Stupp Tobias, Georgalas Ilias, Georgiadou Evi, Moschos Michail, Thanos Solon

Studying IOP during high-altitude ascent/descent, researchers found IOP significantly decreased with hypoxia, then recovered with acclimatization. This suggests IOP changes could help screen for acute mountain sickness.

Schiefer Ulrich, Isbert Melanie, Mikolaschek Eva, Mildenberger Ingrid, Krapp Elke, Schiller Jan et al.

This study analyzed visual field defects in chiasmal lesions, finding incomplete bitemporal hemianopia most common, followed by anterior junction syndrome, which clinically suggests specific nerve fiber involvement but doesn't confirm Wilbrand's knee.

Pavlidis Mitrofanis, Stupp Tobias, Naskar Rita, Cengiz Cani, Thanos Solon

This study found that surviving retinal ganglion cells in advanced glaucoma show significant structural damage to their cell bodies, axons, and dendrites, despite resisting complete degeneration, highlighting ongoing cellular pathology.

Naskar Rita, Wissing Mechthild, Thanos Solon

This rat study found early retinal ganglion cell death and activated microglia occur with elevated eye pressure. In vivo imaging can detect early glaucoma damage, highlighting microglial involvement.