Grus Franz H

Liu Hanhan, Anders Fabian, Thanos Solon, Mann Carolina, Liu Aiwei, Grus Franz H et al.

Hydrogen sulfide (H2S) protected retinal ganglion cells in experimental glaucoma models by reducing stress and dilating vessels, suggesting it's a promising neuroprotective treatment for glaucoma.

Lorenz Katrin, Beck Sabine, Keilani Munir M, Wasielica-Poslednik Joanna, Pfeiffer Norbert, Grus Franz H

This study found three autoantibodies (HSP27, TTLL12, NSE) increased significantly after acute angle-closure glaucoma attacks, suggesting an autoimmune response linked to IOP spikes that could inform glaucoma pathogenesis.

Bell Katharina, Gramlich Oliver W, Von Thun Und Hohenstein-Blaul Nadine, Beck Sabine, Funke Sebastian, Wilding Corina et al.

Autoantibodies in glaucoma are complex, with some contributing to damage and others showing neuroprotective potential. This suggests new diagnostic markers and therapeutic targets.

Bhattacharya Sanjoy K, Lee Richard K, Grus Franz H

Laspas Panagiotis, Gramlich Oliver W, Müller Harald D, Cuny Clemens S, Gottschling Philip F, Pfeiffer Norbert et al.

Immunizing rats with optic nerve antigens caused retinal ganglion cell loss and autoreactive antibodies, suggesting systemic autoimmunity contributes to glaucoma-related neurodegeneration, even without IOP changes.

Gramlich Oliver W, Joachim Stephanie C, Gottschling Philip F, Laspas Panagoitis, Cuny Clemens S, Pfeiffer Norbert et al.

Rats with EAE (MS model) showed retinal neuron loss, antibody deposition, and microglial activation in the eye, suggesting autoimmune mechanisms beyond T-cells contribute to ocular damage in neuroinflammatory diseases.

Joachim Stephanie C, Wax Martin B, Boehm Nils, Dirk Desiree R, Pfeiffer Norbert, Grus Franz H

Ocular ischemia in rats increased autoantibodies, particularly against heat shock and structural proteins, suggesting a complex immune response that may include protective mechanisms after injury.

Joachim Stephanie C, Grus Franz H, Kraft Daniela, White-Farrar Kisha, Barnes George, Barbeck Mike et al.

HSP27 immunization in rats caused retinal ganglion cell loss and altered systemic antibody profiles, suggesting an immune-mediated mechanism for glaucoma independent of IOP, useful for studying antibody involvement.

Joachim Stephanie C, Reichelt Jan, Berneiser Simone, Pfeiffer Norbert, Grus Franz H

Glaucoma patients show distinct autoantibody patterns against optic nerve antigens, including elevated anti-myelin basic protein, suggesting immune mechanisms contribute to optic nerve damage.

Grus Franz H, Joachim Stephanie C, Wuenschig Diana, Rieck Jochen, Pfeiffer Norbert

This review found consistent changes in autoantibody profiles in glaucoma patients, suggesting autoimmunity's role and potential as a novel diagnostic tool for glaucoma detection.

Barleon Lorenz, Hoffmann Esther M, Berres Manfred, Pfeiffer Norbert, Grus Franz H

This study found Dynamic Contour Tonometry and Goldmann Applanation Tonometry IOPs correlate well in glaucoma and healthy eyes, but don't correlate with corneal thickness, suggesting both methods have utility despite some measurement discrepancies.

Grus Franz H, Joachim Stephanie C, Bruns Kai, Lackner Karl J, Pfeiffer Norbert, Wax Martin B

This study found glaucoma patients from Germany and the US share elevated autoantibodies to alpha-fodrin, especially in normal-pressure glaucoma, suggesting a potential autoimmune biomarker for diagnosis or prognosis.

Hoffmann Esther M, Medeiros Felipe A, Kramann Christina, Pfeiffer Norbert, Grus Franz H

This study found RTA measurements of optic nerve topography have high variability, making them unreliable for precise glaucoma diagnosis and monitoring.

Hoffmann Esther M, Bowd Christopher, Medeiros Felipe A, Boden Catherine, Grus Franz H, Bourne Rupert R et al.

This study compared three optic disc imaging methods, finding moderate correlation but significant measurement discrepancies, meaning they are not interchangeable for glaucoma diagnosis.

Joachim Stephanie C, Pfeiffer Norbert, Grus Franz H

This study found distinct autoantibody patterns against retinal and optic nerve antigens in POAG and NTG patients, suggesting different autoimmune mechanisms in glaucoma pathogenesis.