Tombran-Tink Joyce

He Yuan, Ge Jian, Tombran-Tink Joyce

POAG trabecular meshwork cells show defective mitochondrial function and abnormal vulnerability to calcium stress, suggesting targeting calcium regulation could be a glaucoma treatment.

He Yuan, Leung Kar Wah, Zhang Yue-Hong, Duan Shan, Zhong Xiu-Feng, Jiang Ru-Zhang et al.

POAG patients' TM cells show mitochondrial complex I defects, increasing oxidative stress and cell death. Antioxidants protect these cells, suggesting a potential therapeutic target for glaucoma.

Ogata Nahoko, Wada Mitsumasa, Otsuji Tsuyoshi, Jo Nobuo, Tombran-Tink Joyce, Matsumura Miyo

This study found PEDF is expressed in normal rat eyes and choroidal neovascularization (CNV) lesions. This suggests PEDF may modulate CNV, offering a potential therapeutic target.