Villegas-Pérez María P

Martínez-Vacas Ana, Di Pierdomenico Johnny, Gómez-Ramirez Ana María, Vidal-Sanz Manuel, Villegas-Pérez María P, García-Ayuso Diego

High-dose anti-VEGF injections in rats caused significant retinal inflammation and ganglion cell death, suggesting dose-related toxicity that could inform clinical practice.

García-Ayuso Diego, Di Pierdomenico Johnny, Hadj-Said Wahiba, Marie Mélanie, Agudo-Barriuso Marta, Vidal-Sanz Manuel et al.

Taurine depletion causes retinal cell loss, particularly ipRGCs. Light exposure significantly worsens photoreceptor degeneration in taurine-deficient retinas, suggesting taurine supplementation may protect against retinal diseases.

Rovere Giuseppe, Nadal-Nicolás Francisco M, Agudo-Barriuso Marta, Sobrado-Calvo Paloma, Nieto-López Leticia, Nucci Carlo et al.

Rat optic nerve transection showed retinal ganglion cell death is more severe and precedes retinal nerve fiber layer thinning, suggesting RGC loss is an earlier marker of injury.

García-Ayuso Diego, Di Pierdomenico Johnny, Esquiva Gema, Nadal-Nicolás Francisco Manuel, Pinilla Isabel, Cuenca Nicolás et al.

Inherited photoreceptor degeneration causes secondary loss of melanopsin-positive RGCs. Surviving cells show reduced dendrites but increased Brn3a coexpression, suggesting a survival mechanism relevant for vision preservation in retinal diseases.

García-Ayuso Diego, Salinas-Navarro Manuel, Nadal-Nicolás Francisco Manuel, Ortín-Martínez Arturo, Agudo-Barriuso Marta, Vidal-Sanz Manuel et al.

In aged rats with inherited photoreceptor degeneration, sectorial retinal ganglion cell loss is primarily caused by RGC death, though retrograde transport issues also contribute at later stages.

Soro-Martínez María I, Villegas-Pérez María P, Sobrado-Calvo Paloma, Ruiz-Gómez José M, Miralles de Imperial Mora-Figueroa Jaime

This study found combined glaucoma and cataract surgery, especially two-step, causes significantly more corneal endothelial cell loss than trabeculectomy alone, impacting long-term corneal health.