Virgili Gianni

Servillo Andrea, Cutolo Carlo Alberto, Viganò Chiara, Forte Paolo, Manocchio Riccardo, Gazzard Gus et al.

Glaucoma surgical/laser studies show poor adherence (47%) to WGA reporting guidelines, especially for success definitions. This highlights a critical need for updated guidelines and improved reporting to standardize clinical evidence.

Passaro Maria Laura, Buzzi Matilde, Qureshi Riaz, Zou Yuhao, Chan Ving Fai, Mencucci Rita et al.

This study found posterior chamber phakic IOLs have a low complication rate, with vision-threatening events being rare, but short follow-up may underestimate late issues, emphasizing ongoing monitoring.

von Spreckelsen Alexander, Kjær Trine, Reimann Marcel, Torp-Pedersen Christian, Porsborg Andersen Mikkel, Virgili Gianni et al.

Patients dislike severe blurred vision, persistent cosmetic changes, and persistent discomfort from glaucoma drops most. Understanding these preferences can improve adherence and personalized treatment.

Rabiolo Alessandro, Triolo Giacinto, Servillo Andrea, Khaliliyeh Daniela, Jin Sang W, Morales Esteban et al.

Glaucoma surgery success rates vary wildly based on high IOP failure criteria. These IOP-based definitions poorly reflect visual field progression, highlighting the need for standardized criteria and incorporating VF rates for meaningful comparisons.

Rabiolo Alessandro, Triolo Giacinto, Khaliliyeh Daniela, Jin Sang Wook, Morales Esteban, Ghirardi Alessandro et al.

This study found glaucoma surgery hypotony criteria are highly variable; numerical definitions inflate failure rates more than clinical ones, underscoring the need for standardized, clinically relevant criteria.

Protasio Jesa Nadine, King Anthony, Pasquale Louis R, Barton Keith, Bonnar Johnathan, Qureshi Riaz et al.

This study developed methods using a severity classification and total harm score to quantify and compare surgical complications in glaucoma trials, providing a clearer picture of treatment risks.

Daka Qëndresë, Mustafa Rona, Neziri Burim, Virgili Gianni, Azuara-Blanco Augusto

This review found promising home-based perimetry technologies, but current studies in controlled settings show variable diagnostic accuracy and high bias, limiting certainty about real-world clinical value.

Skov Anne Guldhammer, Rives Amalie Santaolalla, Freiberg Josefine, Virgili Gianni, Azuara-Blanco Augusto, Kolko Miriam

This review found preserved and preservative-free beta-blockers have similar IOP-lowering. Preservative-free options may offer better ocular surface health, but stronger evidence is needed for definitive clinical recommendations.

Savastano Alfonso, Bitossi Alice, Giansanti Fabrizio, Vannozzi Lorenzo, Caporossi Tomaso, Barca Francesco et al.

This study found that adding a slow-release dexamethasone implant during epiretinal membrane removal accelerated early visual recovery, but offered no additional long-term visual or anatomical benefits.

Xiong Ying-Zi, Kwon MiYoung, Bittner Ava K, Virgili Gianni, Giacomelli Giovanni, Legge Gordon E

This study found the VA-CS relationship varies significantly across eye diseases, even with normal VA, suggesting CS offers valuable complementary information for early detection and visual impairment assessment.

Michelessi Manuele, Li Tianjing, Miele Alba, Azuara-Blanco Augusto, Qureshi Riaz, Virgili Gianni

This overview of systematic reviews found that OCT's average retinal nerve fiber layer thickness shows moderate sensitivity but high specificity for diagnosing glaucoma, highlighting the need for improved study quality.

Hedengran Anne, Steensberg Alvilda T, Virgili Gianni, Azuara-Blanco Augusto, Kolko Miriam

This review found no significant difference in IOP reduction or common adverse events between BAK-preserved and preservative-free/alternatively preserved glaucoma drops, but safety data had high uncertainty.

Wormald Richard, Virgili Gianni, Azuara-Blanco Augusto

This review found lowering eye pressure reduces glaucoma progression, but comparative effectiveness of different treatments (medicines, laser, surgery) for preventing progression still lacks strong evidence, highlighting a need for focused future research.

Miele Alba, Govetto Andrea, Fumagalli Carlo, Donati Simone, Biagini Ilaria, Azzolini Claudio et al.

Vitrectomy was found to increase open-angle glaucoma risk (7.8% vs. 4.8%), but ocular hypertension and IOP changes were inconsistent. This highlights a need for careful postoperative glaucoma monitoring.

Saldanha Ian J, Lindsley Kristina, Do Diana V, Chuck Roy S, Meyerle Catherine, Jones Leslie S et al.

This study found that for glaucoma, most clinical trial outcomes were not included in systematic reviews. This inconsistency hinders research synthesis and highlights the need for standardized core outcome sets in ophthalmology.

Virgili Gianni, Michelessi Manuele, Cook Jonathan, Boachie Charles, Burr Jennifer, Banister Katie et al.

OCT's RNFL data for glaucoma diagnosis showed moderate accuracy (AUC 0.83-0.88). While useful, its sensitivity/specificity are limited, even with added factors, suggesting it's a supportive, not standalone, diagnostic tool.

Govetto Andrea, Su Daniel, Farajzadeh Matthew, Megerdichian Alin, Platner Eva, Ducournau Yvette et al.

This study found microcystoid macular changes are frequent in eyes with epiretinal membranes and glaucoma. Surgery reduced these changes only in non-glaucomatous eyes, suggesting different underlying mechanisms and treatment responses.

Oddone Francesco, Lucenteforte Ersilia, Michelessi Manuele, Rizzo Stanislao, Donati Simone, Parravano Mariacristina et al.

This review found retinal nerve fiber layer (RNFL) parameters remain slightly better than macular parameters for diagnosing manifest glaucoma with OCT, but differences are small, guiding current diagnostic choices.

Costagliola Ciro, Parmeggiani Francesco, Virgili Gianni, Lamberti Giuseppe, Incorvaia Carlo, Perri Paolo et al.

Latanoprost better reduced circadian IOP and improved ocular perfusion pressure than timolol in normal-tension glaucoma, highlighting its superior clinical benefit for ocular blood flow.

Virgili Gianni, Pierrottet Chiara, Parmeggiani Francesco, Pennino Monica, Giacomelli Giovanni, Steindler Piero et al.

This study found most RP patients have moderately impaired reading, correlating with visual acuity, contrast sensitivity, and visual field. Assess reading in all RP cases, as impairment can occur even with good acuity, and magnification may be limited by field loss.