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Chronology of optic nerve head and retinal responses to elevated intraocular pressure.
Johnson E C, Deppmeier L M, Wentzien S K, Hsu I, Morrison J C
Invest Ophthalmol Vis SciFeb 2000190 citationsBasic Science
This rat study found elevated IOP causes optic nerve and retinal changes, including neurotrophin depletion. However, neurotrophin withdrawal alone doesn't fully explain ganglion cell death, suggesting other mechanisms are involved.