Morrison J C

Burgoyne C F, Morrison J C

Jia L, Cepurna W O, Johnson E C, Morrison J C

Anesthetics significantly reduced IOP in rats with glaucoma, making awake IOP measurements crucial for accurate pressure assessment in animal models.

Jia L, Cepurna W O, Johnson E C, Morrison J C

Rat glaucoma models showed IOP often rose only in the dark phase, causing optic nerve damage. Both light and dark IOP measurements are crucial for assessing glaucoma risk.**

Johnson E C, Deppmeier L M, Wentzien S K, Hsu I, Morrison J C

This rat study found elevated IOP causes optic nerve and retinal changes, including neurotrophin depletion. However, neurotrophin withdrawal alone doesn't fully explain ganglion cell death, suggesting other mechanisms are involved.

Morrison J C, Johnson E C, Cepurna W O, Funk R H

Rat ONH microvasculature was mapped, showing a centripetal blood supply from posterior ciliary arteries similar to primates, but with unique choroidal-nerve sheath vein connections. This aids understanding ONH blood flow in glaucoma models.

Konowal A, Morrison J C, Brown S V, Cooke D L, Maguire L J, Verdier D V et al.

Topical dorzolamide caused irreversible corneal swelling in nine patients with pre-existing endothelial compromise, often requiring corneal transplant. This highlights risks for vulnerable glaucoma patients.

Morrison J C, Nylander K B, Lauer A K, Cepurna W O, Johnson E

Glaucoma drops in rats effectively lowered intraocular pressure and protected optic nerves from damage, suggesting their clinical benefit in preventing glaucoma progression.

Morrison J C, Fraunfelder F W, Milne S T, Moore C G

This study mapped rat limbal microvasculature, finding anatomical similarities to primates in anterior segment blood supply and aqueous drainage. This explains rat models for glaucoma and drug delivery to the trabecular meshwork.

Morrison J C, Rask P, Johnson E C, Deppmeier L

Researchers studied chondroitin sulfate proteoglycans in primate optic nerve heads, finding distinct distribution patterns, particularly in the lamina cribrosa. These differences suggest varied roles in optic nerve head function and glaucoma.

Barnebey H S, Robin A L, Zimmerman T J, Morrison J C, Hersh S B, Lewis R A et al.

This study found brimonidine effectively reduces post-laser trabeculoplasty IOP spikes. A single dose, given either before or after the procedure, significantly lowered the risk of pressure elevation, offering a practical clinical benefit.

Marsh P, Wilson D J, Samples J R, Morrison J C

Noncontact Nd:YAG cyclophotocoagulation destroys ciliary processes, reducing aqueous production and intraocular pressure. This explains its mechanism for glaucoma treatment.

Moore C G, Milne S T, Morrison J C

This study found the Tono-Pen 2 reliably measures rat IOP, though it overestimates low and underestimates high pressures. This tool is useful for glaucoma research in rats, with a correction factor.

Sugiyama K, Bacon D R, Morrison J C, Van Buskirk E M

Rabbit optic nerve head blood supply primarily comes from short posterior ciliary arteries forming an incomplete circle, with pial and retinal arteries also contributing, revealing its complex vascular architecture.

Morrison J C

Morrison J C, Robin A L

Apraclonidine significantly lowered IOP more than dipivefrin or placebo when added to timolol, making it a useful adjunctive glaucoma treatment.

Morrison J C, Van Buskirk E M

Studying canine eyes, pectinate ligament incision significantly improved aqueous outflow, suggesting these ligaments contribute to outflow resistance by compressing filtration structures.