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Glaucoma-Associated Mutations in the Optineurin Gene Have Limited Impact on Parkin-Dependent Mitophagy.
Chernyshova Kseniia, Inoue Keiichi, Yamashita Shun-Ichi, Fukuchi Takeo, Kanki Tomotake
Invest Ophthalmol Vis SciAug 201927 citationsBasic Science
Glaucoma-associated OPTN mutations were studied for their impact on mitophagy. Unlike ALS mutations, glaucoma mutations did not impair mitophagy, suggesting glaucoma's cause isn't via mitophagy defects.