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Ocular safety profile and intraocular pharmacokinetics of an antagonist of EphB4/EphrinB2 signalling.
Brar Manpreet, Cheng Lingyun, Yuson Ritchie, Mojana Francesca, Freeman William R, Gill Parkash S
Br J OphthalmolDec 20108 citationsBasic Science
This study found sEphB4, an EphB4/EphrinB2 antagonist, was safe in rabbit eyes, showing no toxicity and a long intraocular half-life, suggesting it could be a long-acting treatment for ocular neovascularization.