Freeman William R

Most Jesse A, Le An D, Tran Melanie D, Walker Evan H, Swamy Aneesh, Bartsch Dirk-Uwe G et al.

AI-assisted analysis in RP found strong correlation between ellipsoid zone integrity and retinal sensitivity. However, some areas showed function despite no visible EZ, highlighting local structure-function incongruencies.

Sun Yaoyao, Huffman Kristyn, Freeman William R, Cheng Lingyun

A mesoporous silica system delivered ketorolac via subconjunctival injection, sustaining therapeutic levels for 6-8 weeks. This could replace post-cataract surgery eye drops, simplifying patient care.

Ramkumar Hema L, Nguyen Brian, Bartsch Dirk-Uwe, Saunders Luke J, Muftuoglu Ilkay Kilic, You Qisheng et al.

Geographic atrophy patients show reduced central macular ganglion cell layer volume, suggesting ganglion cell loss occurs, potentially impacting vision beyond photoreceptor damage.

Muftuoglu Ilkay Kilic, Lin Tiezhu, Freeman William R

Newly diagnosed neovascular AMD causes inner retinal layers to appear thicker due to edema, which can complicate glaucoma assessment by falsely elevating ganglion cell complex measurements.

Muftuoglu Ilkay Kilic, Ramkumar Hema L, Bartsch Dirk-Uwe, Meshi Amit, Gaber Raouf, Freeman William R

Advanced dry AMD thins the inner plexiform layer, suggesting transsynaptic degeneration, and automatic OCT segmentation often requires correction for accurate assessment.

Barteselli Giulio, Bartsch Dirk-Uwe, Weinreb Robert N, Camacho Natalia, Nezgoda Joseph T, Marvasti Amir H et al.

This study compared OCT technologies, finding FDI SD-OCT better for vitreous/retina visualization, while SS-OCT excelled at choroidal detail. Clinically, technology choice depends on the specific ocular structures needing evaluation.

Barteselli Giulio, Amini Payam, Ezon Isaac C, Nezgoda Joseph T, Cheng Lingyun, Freeman William R

Prophylactic glaucoma drops effectively control IOP after 20mg intravitreal triamcinolone; non-compliance causes significant IOP spikes, especially in non-vitrectomized eyes, emphasizing adherence.

Kim Jae Suk, Chhablani Jay, Chan Candy K, Cheng Lingyun, Kozak Igor, Hartmann Kathrin et al.

SD-OCT-observed extensive epiretinal membrane adherence and fibrillary changes strongly predict increased surgical difficulty during ERM removal, aiding preoperative planning and surgical strategy.

Cheng Sarah, Klein Helaina, Bartsch Dirk-Uwe, Kozak Igor, Marcotte Thomas D, Freeman William R

This study found thinner retinal nerve fiber layers in HIV patients correlated with worse driving simulator performance, suggesting ophthalmologic monitoring is crucial for driving safety.

Goldbaum Michael H, Kozak Igor, Hao Jiucang, Sample Pamela A, Lee TeWon, Grant Igor et al.

Machine learning detected subtle visual field defects in HIV+ patients, even with good immune status, indicating early retinal damage. This highlights the utility of advanced analysis for early detection.

Brar Manpreet, Cheng Lingyun, Yuson Ritchie, Mojana Francesca, Freeman William R, Gill Parkash S

This study found sEphB4, an EphB4/EphrinB2 antagonist, was safe in rabbit eyes, showing no toxicity and a long intraocular half-life, suggesting it could be a long-acting treatment for ocular neovascularization.

Gomez Maria Laura, Mojana Francesca, Bartsch Dirk-Uwe, Freeman William R

Resolved cotton wool spots in HIV patients cause permanent, quantifiable thinning of inner retinal layers, especially ganglion cells, detectable years later by OCT, indicating lasting structural damage.

Cheng Lingyun, Hostetler Karl, Valiaeva Nadya, Tammewar Ajay, Freeman William R, Beadle James et al.

This study found novel intravitreal crystalline prodrugs provide long-lasting, slow-release antiproliferative effects, significantly reducing abnormal eye cell growth, offering a promising treatment for proliferative eye diseases.

Cheng Lingyun, Banker Alay S, Martin Michael, Kozak Igor, Freeman William R

A 20mg intravitreal triamcinolone injection maintains therapeutic aqueous concentrations for ~150 days, suggesting prolonged vitreous effect for treating ocular inflammation.

Freeman William R, Van Natta Mark L, Jabs Douglas, Sample Pamela A, Sadun Alfredo A, Thorne Jennifer et al.

This study found significant vision loss, especially visual field defects (nearly 40%), in AIDS patients without retinitis, correlating with overall disease severity, highlighting a common, unexplained ocular complication.

Kozak Igor, Bartsch Dirk-Uwe G, Cheng Lingyun, McCutchan Allen, Weinreb Robert N, Freeman William R

Scanning laser polarimetry showed HIV-positive patients with a history of very low CD4 counts have retinal nerve fiber layer thinning, suggesting potential glaucoma-like damage even without infectious retinitis.

Falkenstein Iryna A, Cheng Lingyun, Freeman William R

Intravitreal bevacizumab causes a temporary IOP spike that normalizes within 15 minutes. This suggests monitoring IOP for 15 minutes post-injection is sufficient.

Falkenstein Iryna, Kozak Igor, Kayikcioglu Ozcan, Cheng Lingyun, Bartsch Dirk U, Azen Stanley P et al.

This study found HIV patients without retinitis showed inner retinal damage on mfERG, but these defects didn't always align with perimetry. This suggests HIV can independently affect inner retinal function.

Kozak Igor, LaBree Laurie, Azen Stanley P, Cheng Lingyun, Reagan Nicole L, Freeman William R

This study found that in HIV patients, immune recovery (increased CD4 counts) from HAART is associated with a rise in intraocular pressure, reversing HIV-induced IOP reduction.

Schrier Rachel D, Song Mi-Kyoung, Smith Irene L, Karavellas Marietta P, Bartsch Dirk-Uwe, Torriani Francesca J et al.

This study found immune recovery uveitis (IRU) is characterized by high IL-12 and no active CMV, distinguishing it from active CMV retinitis, which has high IL-6. This helps guide IRU diagnosis and treatment.

Kozak Igor, Bartsch Dirk-Uwe, Cheng Lingyun, Kosobucki Brian R, Freeman William R

This study found HIV patients with a history of low CD4 counts, even without CMV retinitis, have significant retinal nerve fiber thinning, suggesting OCT can detect subclinical HIV-related visual damage.

Mueller Arthur J, Freeman William R, Schaller Ulrich C, Kampik Anselm, Folberg Robert

Confocal ICG angiography of small choroidal melanocytic tumors revealed complex microcirculation patterns strongly predict faster tumor growth, offering a novel clinical predictor for management.