Araie Makoto

Using Deep Learning and Transfer Learning to Accurately Diagnose Early-Onset Glaucoma From Macular Optical Coherence Tomography Images.

A DL model for glaucoma using spectral-domain OCT offers a substantive increase in diagnostic performance.

Multiple Temporal Lamina Cribrosa Defects in Myopic Eyes with Glaucoma and Their Association with Visual Field Defects.

Myopic eyes with OAG exhibited LC defects and large pores at similar locations as those without OAG, but in greater numbers, suggesting that these focal alternations of the LC in myopic eyes may evolve into larger defects when glaucoma develops in the eye.

Factors Associated with Progression of Japanese Open-Angle Glaucoma with Lower Normal Intraocular Pressure.

In Japanese patients with NTG with mean baseline IOP of 12.3 mmHg without treatment, estimated mean MD slope for 5 years was -0.33 dB/year; probability of glaucoma progression based on VF or disc/peripapillary end points at 5 years was 66%.

Change in visual acuity and associated risk factors after trabeculectomy with adjunctive mitomycin C.

Visual acuity was significantly reduced after MMC trabeculectomy in 5 years, and we identified several risk factors associated with this complication.

Validating the Usefulness of the "Random Forests" Classifier to Diagnose Early Glaucoma With Optical Coherence Tomography.

It is useful to analyze multiple SDOCT parameters concurrently using the Random Forests method to diagnose glaucoma in early stages.

Optic Disc Margin Anatomic Features in Myopic Eyes with Glaucoma with Spectral-Domain OCT.

The myopic eyes with OAG exhibited characteristic optic disc margin anatomic features that was considered to be derived from myopic deformation of the eye.

The role of specific visual subfields in collisions with oncoming cars during simulated driving in patients with advanced glaucoma.

Our data suggest that the inferior hemifield was associated with the incidence of motor vehicle collisions with oncoming cars in patients with advanced glaucoma.

Long-term Side Effects Including Blepharitis Leading to Discontinuation of Ripasudil.

Blepharitis was the most common reason for discontinuation of ripasudil treatment.

Focal Lamina Cribrosa Defect in Myopic Eyes With Nonprogressive Glaucomatous Visual Field Defect.

In myopic eyes, there are specific patters of LC defect that are suggested to be associated with nonprogressive glaucomatous VFD.

Deep Optic Nerve Head Structures Associated With Increasing Axial Length in Healthy Myopic Eyes of Moderate Axial Length.

A greater misalignment between BMO and ASCO planes, thinner choroid, a more posteriorly bowed PPS, an enlargement of ASCO, and thicker cpRNFLT were each associated with longer AXL.

Beta-peripapillary atrophy of the optic disc and its determinants in Japanese eyes: a population-based study.

The presence and size of β-PPA in normal eyes were correlated with older age, greater disc ovality and disc-fovea distance and lower IOP.

Ocular and Systemic Factors Affecting Laser Speckle Flowgraphy Measurements in the Optic Nerve Head.

Interindividual comparison of MT or MV must be adjusted for both systemic factors (blood pressure or age) and local ocular factors (AL and disc, cup, or β-PPA area).

Genetic Variants Associated With the Onset and Progression of Primary Open-Angle Glaucoma.

The results indicate that non-IOP-related (optic nerve vulnerability) rather than IOP-related (IOP elevation) genetic variants may play an important role in the onset of POAG (family history of glaucoma) and that IOP-related rather than non-IOP-related…

Pseudoexfoliation syndrome and relating factors in a rural Japanese population: the Kumejima Study.

The prevalence rates of PEX syndrome and PEX-G in a south-western island of Japan were reported. PEX showed no significant effect on IOP, and age and working outdoors were significantly related with PEX.

Prevalence of Glaucoma and Its Systemic Risk Factors in a General Japanese Population: The Hisayama Study.

The prevalence of glaucoma was approximately 8%, probably due to the increase in the Japanese aging population.

Glucose Tolerance Levels and Circumpapillary Retinal Nerve Fiber Layer Thickness in a General Japanese Population: The Hisayama Study.

Our analyses revealed that poorer glucose tolerance was significantly associated with the reduction of cpRNFLT in a Japanese general population, suggesting that the loss of neural tissue in the eye begins at the prediabetic stage,…

Genetic Variant Near PLXDC2 Influences the Risk of Primary Open-angle Glaucoma by Increasing Intraocular Pressure in the Japanese Population.

The genetic variant near the PLXDC2 gene was found to influence the risk of POAG by increasing IOP in the Japanese population.

Factors Threatening Central Visual Function of Patients with Advanced Glaucoma: A Prospective Longitudinal Observational Study.

In advanced glaucoma eyes with well-controlled IOP, BCVA, β-peripapillary atrophy area-to-disc area ratio, and use of systemic antihypertensive agents were significant prognostic factors for further deterioration of central visual function.

Vertical asymmetry of lamina cribrosa tilt angles using wide bandwidth, femtosecond mode-locked laser OCT; effect of myopia and glaucoma.

Vertical asymmetry of the LC tilting from the BMO plane exists in both normal and POAG eyes, and correlates with the degree of myopia.

Differences in Factors Associated With Glaucoma Progression With Lower Normal Intraocular Pressure in Superior and Inferior Halves of the Optic Nerve Head.

In NTG eyes, greater BMI, myopia, and v-C/D are characteristic risk factors for faster progression in the superior half of the optic nerve head (ONH), whereas long-term IOP fluctuation is the significant risk factor in…

Differentiating Diagnosed and Undiagnosed Primary Angle-Closure Glaucoma and Open-Angle Glaucoma: A Population-Based Study.

Primary angle-closure glaucoma was more likely to have been diagnosed previously than POAG during a screening examination.

Differences in Retinal Nerve Fiber Layer Thickness as Assessed on the Disc Center and Bruch's Membrane Opening Center in Myopic Eyes.

There was a significant amount of difference in the sectorial cpRNFLT acquired on the disc center and that acquired on the BMO center in the myopic eyes, which was considered to be derived from unique optic disc margin anatomy in these eyes.

Association of Bergmeister Papilla and Deep Optic Nerve Head Structures With Prelaminar Schisis of Normal and Glaucomatous Eyes.

The severity of PLS was strongly associated with the presence of Bergmeister papilla, suggesting a traction-related phenomenon.

Vertical Position of the Central Retinal Vessel in the Optic Disc and Its Association With the Site of Visual Field Defects in Glaucoma.

Eyes with CRVs in the superior ONH region were significantly more likely to form VFDs in the superior hemifields and vice versa.

Primary Open-angle Glaucoma With Initial Visual Field Damage in the Superior and Inferior Hemifields: Comparison in a Population-based Setting.

In POAG, greater disc ovality and β-PPA and thinner central cornea thickness were associated significantly with the initial VFD starting in the superior hemifield, suggesting some difference in the glaucomatous damaging process between the superior…

Effects of ambient atmospheric pressure on intraocular pressure measured using a Goldman applanation tonometer in normal eyes under ordinary conditions.

AP was found to have a significantly positive correlation with GAT-IOP in normal healthy eyes under ordinary conditions, though the actual impact of AP on IOP in normal individuals under ordinary conditions would be minimal.

Spatial and Temporal Relationship between Structural Progression and Disc Hemorrhage in Glaucoma in a 3-Year Prospective Study.

In a 3-year prospective study with a Japanese POAG cohort, the relationship between DH and RNFLD and the pattern of RNFLD progression differed by disc location.

The Inferior, Superior, Temporal Rim Width Pattern (IST Rule) Detects Glaucoma in a Japanese Population.

Among all combinations, the I>S>T rim width pattern, the IST pattern, yielded the highest LR+ in detecting glaucoma in Japanese glaucoma eyes and its failure of or compliance with the pattern significantly correlated with several…

Clinical Assessment of Scleral Canal Area in Glaucoma Using Spectral-Domain Optical Coherence Tomography.

Significantly larger ASC area was first observed in the living human eyes with glaucoma compared to the normal eyes.

The occurrence of optic disc haemorrhage in primary open-angle glaucoma eyes with lower normal pressure and its relating factors.

Disc haemorrhage (DH) occurrence probability of Japanese healthy NTG patients with mean IOP of 12.4 mmHg and no systemic and/or topical treatment was 31% at 5 years.

Evaluation of anterior chamber angle by van Herick grading and ultrasound biomicroscopy in light and dark conditions for finding appositional angle closure and plateau iris configuration.

The VH grade of ≤2 and ≥3 showed significant association with UBM angle width and ciliary body configuration parameters. The VH ≤ 2 criterion should be useful for screening of A-ITC and PI.

Frequencies of 4 Distinct Patterns of Glaucomatous Disc Appearance and Their Clinical Associations in Japanese Population-based Studies.

The FG type occurs most frequently in Japanese POAG followed by the GE type.

Protruded retinal layers within the optic nerve head neuroretinal rim.

Protruded retinal layers are a component of MRW measurements in most normal subjects, occurring in almost 12% of all measurement points analysed.

Associations between Clustered Visual Field Progression and Locations of Disc Hemorrhages in Glaucoma: A 3-Year Prospective Study.

The location of DH was strongly associated with corresponding clustered VF progression in patients with POAG.

Predicting the Extent of Damage in the Humphrey Field Analyzer 24-2 Visual Fields Using 10-2 Test Results in Patients With Advanced Glaucoma.

HFA 24-2 results could be predicted using the paired HFA 10-2 results with reasonable accuracy using LASSO in patients with advanced glaucoma.

Effects of optic nerve head structures on retinal nerve fiber layer defects in primary open angle glaucoma eyes. Analyses using ROTA.

The ROTA-detected extent of axonal damage was associated with ONH structural change represented by gamma zone area in POAG eyes after adjustment for other possible confounding factors.

Asymmetric Retinal Nerve Fiber Layer Defects in Early Glaucoma: A Focus on Superior-Inferior Depth Variability.

The RNFL defects exhibited significantly different locations, distributions, and depths between the inferior and superior retina.

Factors associated with visual field or structure progression occurring first in a prospective study on patients with untreated open-angle glaucoma with normal intraocular pressure.

In OAG eyes with lower normal IOP, DH was significantly associated with Structure First deterioration, and age was significantly associated with Field First deterioration.

Detecting Preperimetric Glaucoma with Standard Automated Perimetry Using a Deep Learning Classifier.

Preperimetric glaucoma VFs can be distinguished from healthy VFs with very high accuracy using a deep FNN classifier.

Correlation of Macular Ganglion Cell Complex Thickness With Frequency-doubling Technology Perimetry in Open-angle Glaucoma With Hemifield Defects.

Similarly strong correlations of the mGCC thickness with the FDT sensitivity in the SAP normal and SAP abnormal halves, but not with the SAP sensitivity, indicates that the mGCC thickness and the FDT sensitivity may…

Differences in Relationship Between Macular Inner Retinal Layer Thickness and Retinal Sensitivity in Eyes With Early and Progressed Glaucoma.

The relationship between the macular GCC and GCIPL thickness and retinal sensitivity at the corresponding retinal areas differed between POAG with mild and advanced central VF damage.

One-year clinical evaluation of 0.4% ripasudil (K-115) in patients with open-angle glaucoma and ocular hypertension.

Fifty-two week administration of 0.4% ripasudil revealed IOP-lowering effects and an acceptable safety profile when administered as monotherapy or as additive therapy, in patients with open-angle glaucoma or OHT.

Reproducibility of Circumpapillary Retinal Nerve Fiber Layer Thickness Measurements Evaluated by Circle and Annulus Area With and Without Correction for Ocular Rotation.

The cpRNFLTannulus measurement yielded better reproducibility than the cpRNFLTring measurement, and multiple linear regression analysis showed that the more advanced the glaucomatous damage, the worse the intervisit reproducibility.

Diagnosis of Early-Stage Glaucoma by Grid-Wise Macular Inner Retinal Layer Thickness Measurement and Effect of Compensation of Disc-Fovea Inclination.

Grid-wise analysis of macular GCC--especially using 8 × 8 grids and normative data-based cutoff values--was very useful for diagnosing early-stage glaucoma, though compensation of the disc-fovea inclination had little effect.

Efficacy and safety of SNJ-1656 in primary open-angle glaucoma or ocular hypertension.

Additive Intraocular Pressure-Lowering Effects of the Rho Kinase Inhibitor Ripasudil (K-115) Combined With Timolol or Latanoprost: A Report of 2 Randomized Clinical Trials.

These clinical trials found additive IOP-lowering effects of ripasudil from placebo at trough and peak levels in combination with timolol and at peak level in combination with latanoprost.

Intra-ocular pressure-lowering effects of a Rho kinase inhibitor, ripasudil (K-115), over 24 hours in primary open-angle glaucoma and ocular hypertension: a randomized, open-label, crossover study.

Ripasudil is a promising new topical medication to lower IOP for at least 7 hr after instillations in patients with POAG or OHT.

Three-dimensional optic nerve head images using optical coherence tomography with a broad bandwidth, femtosecond, and mode-locked laser.

The fine structure of the ONH could be resolved in vivo using our OCT, providing improved imaging that can be used in research and clinical applications for a better characterization of the anatomical and pathological…