Samuel I. Berchuck

Assessment of a Segmentation-Free Deep Learning Algorithm for Diagnosing Glaucoma From Optical Coherence Tomography Scans.

A segmentation-free DL algorithm performed better than conventional RNFL thickness parameters for diagnosing glaucomatous damage on OCT scans, especially in early disease.

Human Versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs.

An M2M DL algorithm performed as well as, if not better than, human graders at detecting eyes with repeatable glaucomatous visual field loss.

Rates of Glaucomatous Structural and Functional Change From a Large Clinical Population: The Duke Glaucoma Registry Study.

Although most patients under routine care had slow rates of progression, a substantial proportion had rates that could potentially result in major losses if sustained over time.

Corneal Biomechanics and Visual Field Progression in Eyes with Seemingly Well-Controlled Intraocular Pressure.

Approximately one-quarter of eyes with well-controlled IOP may show visual field progression over time. Thin cornea and low CH are main risk factors.

Artificial Intelligence Mapping of Structure to Function in Glaucoma.

A CNN was capable of predicting SAP sensitivity thresholds from SDOCT RNFL thickness measurements and generate an SF map from simulated defects.

The Effect of Age on Increasing Susceptibility to Retinal Nerve Fiber Layer Loss in Glaucoma.

Age is a significant modifier of the relationship between IOP and glaucomatous loss in RNFL thickness over time.

Blood Pressure and Glaucomatous Progression in a Large Clinical Population.

When adjusted for IOP, lower MAP and DAP during follow-up were significantly associated with faster rates of RNFL loss, suggesting that levels of systemic BP may be a significant factor in glaucoma progression.

Rapid initial OCT RNFL thinning is predictive of faster visual field loss during extended follow-up in glaucoma.

Rapid RNFL thinning during an initial follow-up period was predictive of concurrent and subsequent rates of visual field decline over an extended period.

Impact of Intraocular Pressure Control on Rates of Retinal Nerve Fiber Layer Loss in a Large Clinical Population.

Intraocular pressure was significantly associated with rates of progressive RNFL loss in a large clinical population.

Rates of Glaucoma Progression Derived from Linear Mixed Models Using Varied Random Effect Distributions.

Linear mixed models using the LG distribution outperformed conventional approaches for estimating rates of SAP MD loss in a population with glaucoma.

Comparison of Short- And Long-Term Variability in Standard Perimetry and Spectral Domain Optical Coherence Tomography in Glaucoma.

Long-term variability was higher than short-term variability on SD-OCT and SAP.

Identifying Risk Factors for Blindness From Glaucoma at First Presentation to a Tertiary Clinic.

Using a large real-world clinical database, we identified risk factors associated with presentation with blindness among glaucoma patients.

Comparing the Rule of 5 to Trend-based Analysis for Detecting Glaucoma Progression on OCT.

Trend-based analysis was superior to the simple rule of 5 for identifying progression in glaucoma eyes and should be preferred as a method for longitudinal assessment of global SD-OCT RNFL change over time.

Effect of Diabetes Control on Rates of Structural and Functional Loss in Patients with Glaucoma.

We did not find a significant association between diabetes control, as measured by levels of HbA1c, and rates of visual field or RNFL loss over time in individuals with glaucoma or suspected glaucoma.

The Relationship Between Asymmetries of Corneal Properties and Rates of Visual Field Progression in Glaucoma Patients.

CH asymmetry between eyes was associated with asymmetry on rates of visual field change, providing further support for the role of CH as a risk factor for glaucoma progression.

Intraocular Pressure and Rates of Macular Thinning in Glaucoma.

Higher IOP was significantly associated with faster rates of GCL and GCIPL loss over time measured by SD-OCT, even during relatively short follow-up times.

Patient Attitudes toward Distress Screening and Referral in Glaucoma Care.

A mixed-methods study of 300 glaucoma patients found strong support for screening and referral for psychological distress.