Budenz Donald L

Five-Year Pooled Data Analysis of the Ahmed Baerveldt Comparison Study and the Ahmed Versus Baerveldt Study.

The Baerveldt group had a lower failure rate, lower rate of de novo glaucoma surgery, and lower mean IOP on fewer medications than the Ahmed group. Baerveldt implantation carried a higher risk of hypotony.

Risk Factors for Failure of Tube Shunt Surgery: A Pooled Data Analysis.

Lower preoperative IOP, neovascular glaucoma, Ahmed implantation, and younger age were predictors of tube shunt failure. This Study provides the largest prospectively collected dataset on tube shunt surgery.

Eight-Year Incidence of Open-Angle Glaucoma in the Tema Eye Survey.

The incidence of OAG is higher in this population than reported in nonblack populations outside Africa.

Association of a Primary Open-Angle Glaucoma Genetic Risk Score With Earlier Age at Diagnosis.

A higher dose of POAG risk alleles was associated with an earlier age at glaucoma diagnosis.

Detecting Visual Field Progression.

Short- and long-term fluctuations as well as inadequate testing frequency are limitations in visual field analysis for glaucomatous progression.

Special Commentary: Reporting Clinical Endpoints in Studies of Minimally Invasive Glaucoma Surgery.

The suggested MCID for the cumulative probability of success for MIGS combined with CE-IOL at 2 years is 65%.

Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets.

Collectively, testosterone metabolism pathway SNPs were consistently associated with the high-tension subtype of POAG in two datasets.

Validation of the UNC OCT Index for the Diagnosis of Early Glaucoma.

The findings confirm that the UNC OCT Index may provide improved diagnostic perforce over that of single OCT parameters and may be a good tool for detection of early glaucoma.

Longitudinal Change in Central Corneal Thickness in the Tema Eye Survey.

CCT decreased significantly over time. The change and rate of change were greater in glaucomatous than normal eyes, and were greater than described in cross-sectional studies.

Glaucoma Screening Using an iPad-Based Visual Field Test in a West African Population.

The MRF underestimated MD and overestimated PSD values compared with the HFA.

Improving Black Patient Question-Asking and Provider Education During Glaucoma Visits.

The intervention increased patient question-asking about glaucoma and glaucoma medications and provider education about glaucoma. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.

Agreement of Diagnostic Classification Between Structural Parameters in Pre-Perimetric and Early Perimetric Glaucoma.

The normative database diagnostic agreements between optic disk, RNFL, and GCIPL were mostly fair in both pre-perimetric and early perimetric glaucoma.

Separation and thickness measurements of superficial and deep slabs of the retinal nerve fiber layer in healthy and glaucomatous eyes.

Glaucomatous RNFL thinning is predominantly detected within a slab with thickness greater than the mode.

Differences in Optical Coherence Tomography Assessment of Bruch Membrane Opening Compared to Stereoscopic Photography for Estimating Cup-to-Disc Ratio.

OCT and photograph reading by clinicians agree poorly in CDR assessment.

Incidence of Glaucoma Progression and Rate of Visual Field Deterioration in a Cohort of Urban Ghanaians.

The incidence and rate of visual field progression are high in this longitudinal study of Ghanaian subjects with glaucoma. The findings may have important clinical and public health policy ramifications.

A Previsit Intervention's Influence on Glaucoma Topics Discussed between Black Patients and Providers.

The intervention significantly increased provider education about many glaucoma and glaucoma medication topics. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Clinicians' Use of Quantitative Information When Assessing the Rate of Structural Progression in Glaucoma.

The rate of change of RNFLT in the most rapidly changing sector predicted experts' assessment of the rate of structural progression better than global rates or MRW.

Clinicians' Use of Quantitative Information while Assessing the Rate of Functional Progression in Glaucoma.

Expert academic glaucoma specialists' assessment of the rate of change correlated best with VFI rates, except in eyes with a VFI near the ceiling of 100%.

Primary Open-Angle Glaucoma Preferred Practice Pattern®.

Primary Open-Angle Glaucoma Suspect Preferred Practice Pattern®.

Chronic Hypotony After Tube Shunt Surgery: A Pooled Analysis of Data From Three Randomized Clinical Trials.

Chronic hypotony is an uncommon complication of tube shunt surgery that usually produces a reduction in VA.

Topographic Agreement of Retinal Nerve Fiber and Ganglion Cell Loss Improves Incipient Glaucoma Detection.

Combining corresponding retinal nerve fiber and ganglion cell layer parameters, factoring in their correlation, significantly improves detection of incipient glaucoma, offering clinicians a powerful diagnostic tool.

Do African American patients with glaucoma ask their eye providers the questions they have?

Although African American subjects with glaucoma have questions about glaucoma and their medications, few asked all their questions during visits. Future research should focus on how to improve question asking using a question prompt list.

African American patient-provider communication about glaucoma vision quality-of-life.

Patients and providers rarely discussed the patient's glaucoma-related quality-of-life. The intervention did not significantly increase communication about glaucoma-related quality-of-life. Residency programs should consider enhancing training regarding discussing patients' quality-of-life.

Thirteen-Year Follow-up of Optic Disc Hemorrhages in the Ocular Hypertension Treatment Study.

ODH is an independent predictive factor for the development of POAG in patients with ocular hypertension (OHT) and the predictive factors for ODH are very similar to those for POAG in OHT patients.

Assessing the Association of Mitochondrial Genetic Variation With Primary Open-Angle Glaucoma Using Gene-Set Analyses.

We present an effective approach for assessing the contributions of mitochondrial genetic variation to open-angle glaucoma.

Central Corneal Thickness and its Associations With Ocular and Systemic Factors in an Urban West African Population.

This population-based cross-sectional survey of West African adults found a significant association between increased CCT and younger age, male sex, and higher IOP but not glaucoma or CDR.

A Statistical Model to Analyze Clinician Expert Consensus on Glaucoma Progression using Spatially Correlated Visual Field Data.

We developed a statistical model for the detection of VF progression defined by clinician expert consensus that accounts for spatially correlated changes in visual sensitivity over time, and showed that it outperformed competing models in…

A Common Variant in MIR182 Is Associated With Primary Open-Angle Glaucoma in the NEIGHBORHOOD Consortium.

Our integrative study is the first to associate rs76481776 with POAG via elevated miR-182 expression.

Postoperative Complications in the Ahmed Baerveldt Comparison Study During Five Years of Follow-up.

Long-term rates of vision-threatening complications and complications resulting in reoperation were higher in the Baerveldt Glaucoma Implant than in the Ahmed Glaucoma Valve group over 5 years of follow-up.

Effect of Adjusting Retinal Nerve Fiber Layer Profile to Fovea-Disc Angle Axis on the Thickness and Glaucoma Diagnostic Performance.

Correcting the RNFL profiles using the fovea-disc angle axis had no consistent effect on the thickness, specificity, and glaucoma diagnostic performance of RNFL parameters. This phenomenon may be specific to different OCT platforms.

Residual and Dynamic Range of Retinal Nerve Fiber Layer Thickness in Glaucoma: Comparison of Three OCT Platforms.

The relative VF sensitivity at which average RNFL thickness reaches the measurement floor, the residual layer thickness, and RNFL dynamic measurement range differ among the three devices.

Stereo Photo Measured ONH Shape Predicts Development of POAG in Subjects With Ocular Hypertension.

Methods for identifying objective, quantitative measurements of 3D ONH structure were developed using a large dataset.

Retinal nerve fibre layer thickness floor and corresponding functional loss in glaucoma.

Global RNFL thinning reaches the floor at a smaller VF loss level with Spectralis than with RTVue.

Author reply: To PMID 24393348.

Five-year treatment outcomes in the Ahmed Baerveldt comparison study.

Similar rates of surgical success were observed with both implants at 5 years.

Longitudinal changes in peripapillary atrophy in the ocular hypertension treatment study: a case-control assessment.

The results did not show a difference in size of the β-zone at baseline between eyes that proceed to develop glaucoma and those that do not.

Combining Frequency Doubling Technology Perimetry and Scanning Laser Polarimetry for Glaucoma Detection.

The multivariable model including GDx-TSNIT, NAP-FDT, and the interaction GDx-TSNIT×NAP-FDT provides the best glaucoma prediction compared with all other multivariable and univariable models.

Clinical impact of 8 prospective, randomized, multicenter glaucoma trials.

Substantial differences were observed in the clinical impact of several RCTs in glaucoma. The reported impact of each study likely reflects several factors including study timing, design, conduct, and interpretation of results.