Crowston Jonathan G

Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: A crossover randomized clinical trial.

Nicotinamide supplementation can improve inner retinal function in glaucoma. Further studies underway to elucidate the effects of long-term nicotinamide supplementation.

A Comparison of Perimetric Results from a Tablet Perimeter and Humphrey Field Analyzer in Glaucoma Patients.

The perimetry results from the MRF have a strong correlation to the HFA outcomes. MRF also has test-retest reliability comparable to HFA.

The coma in glaucoma: Retinal ganglion cell dysfunction and recovery.

We show that functional recovery can occur following a prolonged course of RGC dysfunction and demonstrate how the capacity for recovery can be modified.

Retinal energy metabolism in health and glaucoma.

Bioenergetic-based therapy for glaucoma has a compelling pathophysiological foundation and is supported by recent successes in animal models.

Impact of Normal Aging and Progression Definitions on the Specificity of Detecting Retinal Nerve Fiber Layer Thinning.

This study highlights how current definitions for detecting RNFL thinning have an unacceptably poor level of specificity, and that more stringent definitions are required to avoid misleading interpretations of progression on OCT imaging in clinical practice.

Artificial Intelligence Algorithms to Diagnose Glaucoma and Detect Glaucoma Progression: Translation to Clinical Practice.

AI algorithms applied to fundus photographs for screening purposes may provide good results using a simple and widely accessible test.

Six-month Longitudinal Comparison of a Portable Tablet Perimeter With the Humphrey Field Analyzer.

MRF correlated strongly with HFA across 4 visits over a 6-month period, and has good test-retest reliability. MRF is suitable for monitoring visual fields in settings where conventional perimetry is not readily accessible.

Surgical outcomes of trabeculectomy and glaucoma drainage implant for uveitic glaucoma and relationship with uveitis activity.

Surgical success rate of GDI was not significantly different from trabeculectomy for uveitic glaucoma in this study. Regular monitoring, early and prolonged intensive treatment of ocular inflammation is important for surgical success particularly following trabeculectomy.

Improving the Feasibility of Glaucoma Clinical Trials Using Trend-Based Visual Field Progression Endpoints.

The feasibility of future glaucoma clinical trials can be substantially improved by evaluating differences in the rate of visual field change between groups.

Evaluation of Generative Adversarial Networks for High-Resolution Synthetic Image Generation of Circumpapillary Optical Coherence Tomography Images for Glaucoma.

DL networks trained with synthetic OCT images for glaucoma detection were comparable with networks trained with real images.

A Comparison of the RETeval Sensor Strip and DTL Electrode for Recording the Photopic Negative Response.

Sensor strip electrodes are a viable alternative for recording reproducible PhNRs, especially when values are normalized to the b-wave.

Objective Assessment of Activity Limitation in Glaucoma with Smartphone Virtual Reality Goggles: A Pilot Study.

Smartphone-based virtual reality may be a portable objective simulation test of activity limitation related to glaucomatous visual loss.

Mitochondrial DNA Variation and Disease Susceptibility in Primary Open-Angle Glaucoma.

Mitochondrial DNA ancestral lineages modulate the risk for primary open-angle glaucoma in populations of European descent.

Glaucoma laser and surgical procedure rates in Australia.

There has been a substantial increase in laser trabeculoplasty procedures in Australia, following a decline between 1994 and 2003.

Baseline Detrending for the Photopic Negative Response.

Baseline detrending can improve the PhNR repeatability without compromising its clinical use in glaucoma. Further studies exploring more complex processing methods are encouraged.

Experimental models of glaucoma filtration surgery.

However, this research needs to be interpreted in the light of the specific study design, animal model and methods used.

Short-Term Changes in the Photopic Negative Response Following Intraocular Pressure Lowering in Glaucoma.

The optimized protocol for measuring the PhNR detected short-term improvements in a proportion of participants following IOP reduction, although the majority showed no change.

Multivariate Normative Comparison, a Novel Method for Improved Use of Retinal Nerve Fiber Layer Thickness to Detect Early Glaucoma.

The multivariate normative database of RNFL showed better glaucoma discrimination capability than conventional age-matched comparisons, suggesting that accounting for demographic and anatomic variance in RNFL thickness may have usefulness in improving glaucoma detection.

Optimizing a Portable ERG Device for Glaucoma Clinic: The Effect of Interstimulus Frequency on the Photopic Negative Response.

An interstimulus frequency of 2 Hz was optimal for recording the PhNR, creating a good balance between testing time and signal quality.

Bleb-associated endophthalmitis: Proportion, presentation, management and outcomes in Victoria, Australia.

Bleb-associated endophthalmitis is an uncommon complication following glaucoma filtration surgery. The proportion has remained stable over time. Visual outcomes remain poor.

A Minimally Invasive Experimental Model of Acute Ocular Hypertension with Acute Angle Closure Characteristics.

Our minimally invasive model resulted in acute OHT with characteristics of AAC in the absence of non-OHT-related neuroinflammatory changes arising from ocular injury alone.

"Doctor, what else can I do for my glaucoma?" Exercise, nicotinamide and other lifestyle interventions.

Advancing neuroprotection in glaucoma and AMD - a new horizon?

The Association of Muscle-Related Factors With Glaucoma and Related Traits in a Large United Kingdom Population.

In this cross-sectional and gene-environment interaction study, factors relating to muscle strength, mass, and function were consistently associated with higher IOP, thicker inner retinal OCT measures in both sexes, and lower odds of glaucoma in…

Photopic Negative Response Obtained Using a Handheld Electroretinogram Device: Determining the Optimal Measure and Repeatability.

The PhNR/B ratio was the measure that minimized variability, and its measurements using a novel handheld ERG system with self-adhering skin electrodes and the protocols described in this study were comparable under different testing conditions…

Test-Retest Variability of Fundus-Tracked Perimetry at the Peripapillary Region in Open Angle Glaucoma.

On a pointwise basis, the test-retest variability of visual sensitivity in glaucoma is not just related to its measured level, but also its local gradient when using fundus-tracked perimetry.

Measuring the Photopic Negative Response: Viability of Skin Electrodes and Variability Across Disease Severities in Glaucoma.

Skin electrodes are a viable alternative to conjunctival electrodes when measuring the PhNR in open angle glaucoma, and increasing the number of sweeps substantially reduced its intrinsic variability; the extent of variability was also lower…

Glaucoma neurorecovery - a sugar-coated road to retinal ganglion cell recovery.

Determination of bleb capsule porosity with an experimental glaucoma drainage device and measurement system.

Our experimental method permits direct measurement of capsular porosity of an in situ GDD.

Clinical audit examining the impact of benzalkonium chloride-free anti-glaucoma medications on patients with symptoms of ocular surface disease.

BAK-free anti-glaucoma preparations were associated with a change in lubricant use, suggesting reduction in some OSD symptoms, but more research is needed.

Cataract and quality of life in patients with glaucoma.

Cataract influences glaucoma-related QoL among glaucoma patients of all severity levels and is an important cause of potentially reversible visual impairment among glaucoma patients.

Role of adenosine receptors in resveratrol-induced intraocular pressure lowering in rats with steroid-induced ocular hypertension.

Topically applied trans-resveratrol reduces IOP in rats with steroid-induced ocular hypertension. Trans-resveratrol-induced oculohypotension involves its agonistic activity at the A₁ AR.