Carlos Gustavo De Moraes

Efficacy of a Deep Learning System for Detecting Glaucomatous Optic Neuropathy Based on Color Fundus Photographs.

Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial.

A combination of nicotinamide and pyruvate yielded significant short-term improvement in visual function, supporting prior experimental research suggesting a role for these agents in neuroprotection for individuals with glaucoma and confirming the need for long-term…

Association Between Undetected 10-2 Visual Field Damage and Vision-Related Quality of Life in Patients With Glaucoma.

The 10-2 VF model showed a stronger association with NEI VFQ-25 score than the 24-2 VF model.

An Artificial Intelligence Approach to Detect Visual Field Progression in Glaucoma Based on Spatial Pattern Analysis.

The archetype method can inform clinicians of VF progression patterns.

Association Between 24-Hour Intraocular Pressure Monitored With Contact Lens Sensor and Visual Field Progression in Older Adults With Glaucoma.

Results of this study indicate that 24-hour CLS recordings may be associated with prior rates of visual field progression of glaucoma.

Artificial Intelligence Classification of Central Visual Field Patterns in Glaucoma.

We quantified central VF patterns in glaucoma, which were used to improve the prediction of central VF worsening compared with using only global indices.

Characterization of Central Visual Field Loss in End-stage Glaucoma by Unsupervised Artificial Intelligence.

In this study, central VF loss in end-stage glaucoma was found to exhibit characteristic patterns that might be associated with different subtypes.

Challenges to the Common Clinical Paradigm for Diagnosis of Glaucomatous Damage With OCT and Visual Fields.

In principle, the CCP could be modified easily. In practice, change is facing a number of impediments.

Reversal of Glaucoma Hemifield Test Results and Visual Field Features in Glaucoma.

Using VF features may predict the GHT results reversal to WNL after 2 consecutive ONL results.

Agreement and Predictors of Discordance of 6 Visual Field Progression Algorithms.

This extremely large comparative series demonstrated that existing algorithms have limited agreement and that agreement varies with clinical parameters, including institution.

Association of Macular Visual Field Measurements With Glaucoma Staging Systems.

These findings suggest that current glaucoma staging systems based on 24-2 (or 30-2) visual fields underestimate disease severity and the presence of macular damage.

Measuring Rates of Visual Field Progression in Linear Versus Nonlinear Scales: Implications for Understanding the Relationship Between Baseline Damage and Target Rates of Glaucoma Progression.

There is a significant relationship between baseline visual field severity and rates of MD progression, although the direction of this association depends on the scale sensitivity is measured.

Fast Progressors in Glaucoma: Prevalence Based on Global and Central Visual Field Loss.

This study found that approximately 1 in 8 eyes with glaucoma receiving routine care showed fast progression based on global MD values (< -1.0 dB/year) and that nearly 1 in 3 eyes showed a < -0.5 dB/year decline centrally.

Review of Hygiene and Disinfection Recommendations for Outpatient Glaucoma Care: A COVID Era Update.

This review focuses on best practices and recommendations for hygiene and disinfection to limit exposure and transmission of infection in outpatient glaucoma clinics during the current COVID-19 pandemic.

Intraocular Pressure Responses to Maximal Cycling Sprints Against Different Resistances: The Influence of Fitness Level.

We conclude that (1) IOP is sensitive to cycling resistance in all-out sprints, with a lowering effect on the lightest resistance and an increasing effect with medium and heavy resistances, (2) high fitness level is…

An Automated Method for Assessing Topographical Structure-Function Agreement in Abnormal Glaucomatous Regions.

The method described here can automatically and objectively evaluate aS-aF agreement with a direct comparison of abnormal regions of function and structure.

Manhattan Vision Screening and Follow-up Study in Vulnerable Populations (NYC-SIGHT): Design and Methodology.

This study targets vulnerable populations where they live to ensure improved access to and utilization of eye care services in those who are least likely to seek eye care.

Predicting Global Test-Retest Variability of Visual Fields in Glaucoma.

Inclusion of archetype VF loss patterns and TD values based on first VF improved the prediction of the global test-retest variability than using traditional global VF indices alone.

Central-most Visual Field Defects in Early Glaucoma.

Given the significance and effect of perimetric factors at abnormal test points in the central 5 degrees of 24-2 VFs, these eyes deserve attention to determine the severity of and functional impact on the CMVFD…

Detection of Progression With 10-2 Standard Automated Perimetry: Development and Validation of an Event-Based Algorithm.

A new event-based progression algorithm using the 10-2 VF can identify eyes experiencing more rapid MD progression and may be used as a tool to assess progressive macular functional changes in glaucoma.

The OCT RNFL Probability Map and Artifacts Resembling Glaucomatous Damage.

Glaucoma-like artifacts on RNFL p-maps are relatively common and can masquerade as arcuate and/or widespread/temporal damage.

Strategies to Improve Convolutional Neural Network Generalizability and Reference Standards for Glaucoma Detection From OCT Scans.

CNN generalizability can be improved with data augmentation, multiple input image modalities, and training on images with confident ratings.

Central Visual Field Defects in Patients with Distinct Glaucomatous Optic Disc Phenotypes.

The severity and prevalence of central VF loss varied among different glaucomatous optic disc phenotypes.

Improving the Detection of Glaucoma and Its Progression: A Topographical Approach.

Together, the RNF bundle model and the automated structure-function method should improve the power of topographical methods for detecting glaucoma and its progression.

A Deep Learning Approach to Improve Retinal Structural Predictions and Aid Glaucoma Neuroprotective Clinical Trial Design.

Our deep learning models were able to accurately estimate both macula GCIPL and ONH RNFL hemiretinal thickness.

Characteristics of Central Visual Field Progression in Eyes with Optic Disc Hemorrhage.

Central VF loss is accelerated in glaucoma eyes with DH and it corresponds topographically to the DH location.

A Topographic Comparison of OCT Minimum Rim Width (BMO-MRW) and Circumpapillary Retinal Nerve Fiber Layer (cRNFL) Thickness Measures in Eyes With or Suspected Glaucoma.

Although BMO-MRW and cRNFL measures agreed in the majority of hemidiscs, they still disagreed in over 25% of the EG hemidiscs.

Screening and Interventions for Glaucoma and Eye Health Through Telemedicine (SIGHT) Studies.

Association between Rates of Retinal Nerve Fiber Layer Thinning and Previous Disc Hemorrhage in Glaucoma.

A history of DH is an independent risk factor for faster rates of RNFL thinning in non-DH quadrants and in DH quadrants; this risk is present even in eyes that exhibited DH several years earlier.

Optical Coherence Tomography and Glaucoma Progression: A Comparison of a Region of Interest Approach to Average Retinal Nerve Fiber Layer Thickness.

In this population, RNFL thinning in a ROI is a better measure of progression than is average cpRNFL thickness change.

Detection of Early Glaucomatous Damage: Performance of Summary Statistics From Optical Coherence Tomography and Perimetry.

OCT and VF metrics, single or in combinations, have only moderate sensitivity for eyes with early glaucoma.

A Model of Progression to Help Identify Macular Damage Due to Glaucoma.

Second, the patterns of progression predicted by the model suggest alternative end points for clinical trials. Finally, the model provides a heuristic for future research concerning the anatomic basis of glaucomatous damage.

Variability and Power to Detect Progression of Different Visual Field Patterns.

Time to detect central VF progression was reduced with 10-2 MD compared with 24-2 and C24-2 MD in glaucoma eyes in this large dataset, in part because 10-2 tests had lower variability.

A Comparison of Retrobulbar Versus Topical Anesthesia in Trabeculectomy and Aqueous Shunt Surgery.

Although supplemental anesthesia and pain scores were statistically increased in the topical group, the prevalence and the severity of pain was low.

Validating Trend-Based End Points for Neuroprotection Trials in Glaucoma.

The trend-based methods can efficiently detect treatment effects defined by long-term FDA-compatible progression.

The 24-2 Visual Field Guided Progression Analysis Can Miss the Progression of Glaucomatous Damage of the Macula Seen Using OCT.

In eyes with early glaucoma (i.e., 24-2 MD, > -6 dB) in this study, the 24-2 GPA missed progression seen using OCT and exhibited a relatively high rate of false positives.

Interindividual Variations in Foveal Anatomy and Artifacts Seen on Inner Retinal Probability Maps from Spectral Domain OCT Scans of the Macula.

Fovea morphology, as measured based upon width, depth, and slope, has a minor role in explaining artifacts seen on macular scans.

Inter-Eye Association of Visual Field Defects in Glaucoma and Its Clinical Utility.

VF patterns of the worse eye are predictive of VF defects in the better eye.

Deep Defects Seen on Visual Fields Spatially Correspond Well to Loss of Retinal Nerve Fiber Layer Seen on Circumpapillary OCT Scans.

Although studies relating local structural (OCT) and functional (VF) measures typically show poor to moderate correlations, there is good qualitative agreement between the location of deep cpRNFL loss and deep defects on VFs.

The ICD-10 Glaucoma Severity Score Underestimates the Extent of Glaucomatous Optic Nerve Damage.

The ICD-10 system relies solely on damage seen on the 24-2 and as provides a 24-2 functional score rather than a "glaucoma" severity score.

Natural History of Normal-Tension Glaucoma with (Very) Low Intraocular Pressure.

A Pattern-Based OCT Metric for Glaucoma Detection.

The new metric outperformed other OCT metrics for detecting glaucomatous damage.

Transformer-Based Deep Learning Prediction of 10-Degree Humphrey Visual Field Tests From 24-Degree Data.

The predicted 10-2 VF has the potential to improve glaucoma diagnosis.

Progression of Early Glaucomatous Damage: Performance of Summary Statistics From Optical Coherence Tomography and Perimetry.

Although relying solely on metrics is not recommended for clinical purposes, in situations requiring very high specificity and precision, combinations of OCT-OCT metrics can be used.

Glaucoma Detection Using Optical Coherence Tomography: Reviewing the Pitfalls of Comparison to Normative Data.

This review describes various artifacts that originate from using a normative database to compare the individual's scans.

Detecting Established Glaucoma Using OCT Alone: Utilizing an OCT Reading Center in a Real-World Clinical Setting.

An OCT-based reading center is able to identify eyes with established glaucoma using OCT alone with high sensitivity and specificity.

Identifying Rapid Glaucoma Progression Using Hemifield Rates of Progression.

Hemifield ROPs are more sensitive to focal progression (or faster progression) than global rates and can aid in tailoring management and treatment decisions.

Risk Calculation in the Medication Arm of the Ocular Hypertension Treatment Study.

The OHTS calculator can be applied to treated patients with OHTN, and repeat risk calculation after initiating IOP reduction may provide useful information that can aid in disease management.

Combined Use of Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma-Reply.

Performance of General-Purpose Vision Language Models and Ophthalmology Foundation Models in Glaucoma Detection and Function Prediction.

Fine-tuned VLMs demonstrated high performance in glaucoma detection and VF MD prediction, matching or exceeding specialized foundation models and traditional convolutional neural network (CNN)-based methods.

Test of a Retinal Nerve Fiber Bundle Trajectory Model Using Eyes With Glaucomatous Optic Neuropathy.

The arcuate model performed well in predicting the borders of arcuate patterns seen on RNFL p-maps. It also predicted the associated abnormal regions of the cpRNFL thickness plots.

Clinicians' Use of Quantitative Information while Assessing the Rate of Functional Progression in Glaucoma.

Expert academic glaucoma specialists' assessment of the rate of change correlated best with VFI rates, except in eyes with a VFI near the ceiling of 100%.

Clinicians' Use of Quantitative Information When Assessing the Rate of Structural Progression in Glaucoma.

The rate of change of RNFLT in the most rapidly changing sector predicted experts' assessment of the rate of structural progression better than global rates or MRW.

Characterization of Temporal Delay and Modeling of Intraocular Pressure and Visual Field Progression in the African Descent and Glaucoma Evaluation Study (ADAGES).

ROP changes trail IOP changes by 4-7 months, an important consideration when obtaining additional VFs to capture or rule-out progression.

Larger Real-World OCT Reference Database Improves Accuracy of Glaucoma Flagging Using Summary Metrics.

There is a difference in the eyes flagged, and this difference is largely due to the greater size of the RW-RDB.

Nicotinamide and Pyruvate in Open-Angle Glaucoma: A Randomized Controlled Trial on Neuroprotection-Design and Methodology.

This novel trial design may deliver valuable data on the neuroprotective potential of nicotinamide and pyruvate supplementation in glaucoma and improve our understanding of optimal study design for longitudinal randomized clinical trials focused on glaucoma neuroprotection.

Dual-Level Pattern Tree for Visual Field Improves Glaucoma Progression and Polygenic Risk Prediction.

Trunk-branch VF classifiers were superior to trunk-only characterizations for predicting functional progression and glaucoma PRS.

The Impact of Myopia on Regional Visual Field Loss and Progression in Glaucoma.

Lower SE values are associated with worse paracentral VF loss. Worse myopia is associated with functional progression, even when excluding patients with high myopia.

Understanding Patterns of Preserved Retinal Ganglion Cell Layer in Advanced Glaucoma as Seen With Optical Coherence Tomography.

All eyes with advanced glaucoma had damage to the critically important central, donut-shaped GCL region.

In Reply: Calcium Channel Blockers and Risk of Primary Open-angle Glaucoma.

Reply.

Factors Associated with Retinal Microvasculature Dropout Induced by Elevation of Intraocular Pressure in Primary Open-Angle Glaucoma.

Acute IOP elevation induced with OPD, but not adduction gaze, decreased peripapillary VD measured with OCT-A imaging.

Visual field progression patterns in the ocular hypertension treatment study correspond to vulnerability regions of the disc.

Development of VF loss in ocular hypertensive eyes appears to be consistent with the vulnerability zones previously described in glaucomatous eyes with established VF loss.

Improving glaucoma staging in clinical practice by combining the ICD-10 glaucoma severity classification system and optical coherence tomography.

Combining OCT and VF data provides better staging of glaucoma severity than VF data alone.

Author Response: Challenges to the Common Clinical Paradigm for Diagnosis of Glaucomatous Damage With OCT and Visual Fields.

Reply.

Technology and the Glaucoma Suspect.

Compared to VF and disc photography, SD-OCT, when used alone, had better internal agreement as well as better agreement with the consensus of clinicians using all available data.

African Descent and Glaucoma Evaluation Study (ADAGES): Racial Differences in Optic Disc Hemorrhage and Beta-Zone Parapapillary Atrophy.

Subjects of ED are at higher risk for developing DH compared with AD subjects, whereas AD subjects have greater prevalence of βPPA.

Visual Field Change and 24-Hour IOP-Related Profile with a Contact Lens Sensor in Treated Glaucoma Patients.

Intraocular pressure-related parameters obtained with 24-hour recording with a CLS were associated with the rate of visual field progression in treated glaucomatous eyes.

The 24-2 Visual Field Test Misses Central Macular Damage Confirmed by the 10-2 Visual Field Test and Optical Coherence Tomography.

Eyes with macular glaucomatous damage may be classified as normal based on the 24-2 VF alone.

Why Do People (Still) Go Blind from Glaucoma?