Huang David

Projection-Resolved Optical Coherence Tomography Angiography of Macular Retinal Circulation in Glaucoma.

On the basis of PR-OCTA, glaucoma preferentially affects perfusion in the SVC in the macula more than the deeper plexuses.

Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field.

OCT is more sensitive than VF for the detection of progression in early glaucoma. While the utility of NFL declines in advanced glaucoma, GCC remains a sensitive progression detector from early to advanced stages.

Plexus-specific retinal vascular anatomy and pathologies as seen by projection-resolved optical coherence tomographic angiography.

Plexus-specific visualization and measurement of retinal vascular changes are improving our ability to diagnose, stage, monitor, and assess treatment response in a wide variety of optic nerve and retinal diseases.

Optical Coherence Tomography Angiography of the Peripapillary Retina in Primary Angle-Closure Glaucoma.

In acute PACG eyes, peripapillary retinal VD decreased significantly compared with the contralateral unaffected eyes. Peripapillary retinal VD was significantly correlated with other glaucomatous changes.

Wide-Field OCT Angiography Investigation of the Relationship Between Radial Peripapillary Capillary Plexus Density and Nerve Fiber Layer Thickness.

The wide distribution of dense overlapping RPCP suggests that wider (up to 8 mm vertical and 7 mm horizontal) OCTA scans may be better investigate capillary loss in the early stages of glaucoma or other…

Baseline Fourier-Domain Optical Coherence Tomography Structural Risk Factors for Visual Field Progression in the Advanced Imaging for Glaucoma Study.

Focal GCC and NFL loss as measured by FDOCT are the strongest predictors for VF progression among the measurements considered.

Projection-Resolved Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma.

In this glaucoma group, reduction in perfusion was more pronounced in superficial layers of the peripapillary retina (NFLP and SVC) than in the deeper layers.

Predictive Factors for the Rate of Visual Field Progression in the Advanced Imaging for Glaucoma Study.

Focal loss measured by FD-OCT or VF along with CCT are strong baseline predictors for the rate of glaucoma progression.

Reduced Retinal Vessel Density in Primary Angle Closure Glaucoma: A Quantitative Study Using Optical Coherence Tomography Angiography.

Retinal vessel density was significantly reduced in PACG eyes. The magnitude of this difference varied between the fundus areas, and was greater in the peripapillary area.

Measuring Glaucomatous Focal Perfusion Loss in the Peripapillary Retina Using OCT Angiography.

The low-perfusion map and LPA and FPL parameters are able to assess the location and severity of focal glaucoma damage with good agreement with VF.

Focal Loss Analysis of Nerve Fiber Layer Reflectance for Glaucoma Diagnosis.

Azimuthal filtering reduces the variability of NFL reflectance measurements. Focal NFL reflectance loss has excellent glaucoma diagnostic accuracy compared to the standard NFL thickness parameters. The reflectance map may be useful for localizing NFL defects.

Nerve Fiber Flux Analysis Using Wide-Field Swept-Source Optical Coherence Tomography.

Using an algorithm based on the conservation of flux, we derived nerve fiber trajectories in the peripapillary area.

Sectorwise Visual Field Simulation Using Optical Coherence Tomographic Angiography Nerve Fiber Layer Plexus Measurements in Glaucoma.

OCTA-based simulated VF agreed well with actual 24-2 VF in terms of both the location and severity of glaucoma damage, with the exception of severe glaucoma in which the simulation tended to underestimate severity.

Relating glaucomatous visual field loss to retinal oxygen delivery and metabolism.

Combined measurements of retinal blood flow and oxygen saturation in glaucomatous individuals suggest VF loss is associated with impaired oxygen delivery and augmented OEF.

Regression-Based Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography.

Myopic eyes are biased to have lower NFLT, GCCT, and NFLP-CD measurements. AL- and SE-based adjustments were effective in mitigating this bias.

Relationship Between Macular Vessel Density and Total Retinal Blood Flow in Primary Open-angle Glaucoma.

The finding of an association between macular VD and TRBF supports the role of vascular factors in the pathophysiology of POAG and potential conduct of future studies aimed at identifying multiple image-based vascular metrics for…

Glaucomatous Focal Perfusion Loss in the Macula Measured by Optical Coherence Tomographic Angiography.

Assessment of macular FPL using OCTA is useful in evaluating glaucomatous damage.

Anatomy of the Macular Ganglion Cell Layer Plexus on Projection-Resolved Optical Coherence Tomographic Angiography.

We defined the anatomic GCLP slab in the macula on PR-OCTA, which is the anterior 75% of the combined GCIPL.

Differentiating Multiple Sclerosis and Glaucoma With Sectoral Pattern Analysis of Peripapillary Nerve Fiber Layer.

Normalizing NFL reduction as a percentage of normal reference accentuated patterns characteristic of MS and glaucoma. Quantitative pattern indexes were effective in differentiating the two diseases.

Sector-Based Regression Strategies to Reduce Refractive Error-Associated Glaucoma Diagnostic Bias When Using OCT and OCT Angiography.

The effect of optical magnification is even more prominent among sectors than the global parameters. AL- and SE-based adjustments should be individualized to each sector to mitigate this magnification bias effectively.

Regression Analysis of Optical Coherence Tomography Disc Variables for Glaucoma Diagnosis.

Our various regression approaches were not able to significantly improve disc-based OCT glaucoma diagnosis.

Optical Coherence Tomography Angiography Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes.

Optical coherence tomography angiography vessel density had similar diagnostic accuracy to RNFL thickness measurements for differentiating between healthy and glaucoma eyes.

Glaucoma Increases Retinal Surface Contour Variability as Measured by Optical Coherence Tomography.

Retinal surface contour variability was significantly increased in glaucoma patients.

Longitudinal and Cross-Sectional Analyses of Age Effects on Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness by Fourier-Domain OCT.

Longitudinal and cross-sectional analyses provided consistent rates of approximately 0.2% per year of age-related thinning in NFL and GCC thicknesses.

Predicting Development of Glaucomatous Visual Field Conversion Using Baseline Fourier-Domain Optical Coherence Tomography.

Reductions in NFL and GCC thickness can predict the development of glaucomatous VF loss in glaucoma suspects and preperimetric glaucoma patients.

Effect of Signal Intensity on Measurement of Ganglion Cell Complex and Retinal Nerve Fiber Layer Scans in Fourier-Domain Optical Coherence Tomography.

Repeatability of RNFL and GCC thickness measurements may be improved by excluding images with cropped anatomic features and weak signal strength below recommended SSI cutoffs.

Optical Coherence Tomography Angiography of the Peripapillary Retina in Glaucoma.

Using OCT angiography, reduced peripapillary retinal perfusion in glaucomatous eyes can be visualized as focal defects and quantified as peripapillary flow index and peripapillary vessel density, with high repeatability and reproducibility.

Combining measurements from three anatomical areas for glaucoma diagnosis using Fourier-domain optical coherence tomography.

Combining structural measurements of GCC, NFL and disc variables from FD-OCT created a GSDI that improved the accuracy for glaucoma diagnosis.

Advanced imaging for glaucoma study: design, baseline characteristics, and inter-site comparison.

Site-to-site variation was smaller than both the variation within groups and the changes attributable to glaucoma. Therefore pooling of participants between sites is appropriate.