Johnson Chris A

Oral Memantine for the Treatment of Glaucoma: Design and Results of 2 Randomized, Placebo-Controlled, Phase 3 Studies.

With technologies available when the studies were conducted, daily treatment with memantine over 48 months was not shown to prevent glaucomatous progression in this patient population.

Performance of an iPad Application to Detect Moderate and Advanced Visual Field Loss in Nepal.

The number of missed locations on the VFE correlated with mean deviation (MD, r = 0.79), pattern standard deviation (PSD, r = 0.60), and number of locations that were worse than the 95% confidence limits for total deviation (r = 0.51) and pattern deviation (r = 0.68) using SITA Standard.

A Comparison between the Compass Fundus Perimeter and the Humphrey Field Analyzer.

Relative diagnostic precision of the 2 devices is equivalent. Test-retest variability of MS for CMP was better than for HFA.

Visual field defect classification in the Zhongshan Ophthalmic Center-Brien Holden Vision Institute High Myopia Registry Study.

A proposed combined visual field classification for high myopia and glaucoma demonstrates acceptable intergrader agreement.

Assessment of Cumulative Incidence and Severity of Primary Open-Angle Glaucoma Among Participants in the Ocular Hypertension Treatment Study After 20 Years of Follow-up.

In this study, only one-fourth of participants in the Ocular Hypertension Treatment Study developed visual field loss in either eye over long-term follow-up.

Optical Coherence Tomography Analysis Based Prediction of Humphrey 24-2 Visual Field Thresholds in Patients With Glaucoma.

The proposed RGC-AC optimized predictive algorithm based on 9-field OCT image analysis and the RGC-AC concept is superior to previous methods and its performance is close to the reproducibility of HVF 24-2.

Predicting Visual Disability in Glaucoma With Combinations of Vision Measures.

Vision in glaucoma is a multidimensional construct that can be described by several variably-correlated vision measures. Measuring more than two vision tests does not substantially improve models for activity limitation.

Machine-Identified Patterns of Visual Field Loss and an Association with Rapid Progression in the Ocular Hypertension Treatment Study.

An automated machine learning system can identify patterns of VF loss and could provide objective and reproducible nomenclature for characterizing early signs of visual defects and rapid progression in patients with glaucoma.

An Objective and Easy-to-Use Glaucoma Functional Severity Staging System Based on Artificial Intelligence.

We discovered that 4 severity levels based on MD thresholds of -2.2, -8.0, and -17.3 dB, provides the optimal number of severity stages based on unsupervised and supervised machine learning.

Do Additional Testing Locations Improve the Detection of Macular Perimetric Defects in Glaucoma?

Visual field examinations with additional macular locations can improve the detection of macular defects in GON modestly without loss of specificity when appropriate criteria are selected.

Comparison of a Novel Head-mounted Perimeter vs. the Humphrey Field Analyzer.

The SSVR headset is a novel visual field testing device that produces similar results to the HFA with a shorter testing duration.

Demographic, Comorbid, and Clinical Variables Associated With Pointwise Visual Field Damage in Glaucoma: Data From the AGIS and CIGTS Clinical Trials.

The approach used provides new longitudinal and cross-sectional insights into variation across the VF associated with demographic, comorbid, and clinical variables.

Visual Field Progression in the Ocular Hypertension Treatment Study.

Some participants in OHTS had rapid rates of VF loss in one or both eyes despite being followed in a clinical study.

Identifying Factors Associated With Fast Visual Field Progression in Patients With Ocular Hypertension Based on Unsupervised Machine Learning.

Unsupervised clustering can objectively identify OHT subtypes including those with fast VF worsening without human expert intervention.

Predicting conversion to glaucoma using standard automated perimetry and frequency doubling technology.

Predictive information is present in visual field results, even when they are still within normal limits.

Visual Field Endpoints Based on Subgroups of Points May Be Useful in Glaucoma Clinical Trials: A Study With the Humphrey Field Analyzer and Compass Perimeter.

Restricting analysis to particular subsets of points of interest in the VF after censoring points with low sensitivity, as compared with using the familiar total field MD, can provide outcome measures with a broader range…

Long-Term Follow-Up of Normal Tension Glaucoma Patients With TBK1 Gene Mutations in One Large Pedigree.

We provide the first report of the clinical features and long-term clinical course in a family of NTG patients with TBK1 gene duplications.

SITA-Standard perimetry has better performance than FDT2 matrix perimetry for detecting glaucomatous progression.

HFA SAP identifies glaucomatous visual field progression at a rate at least as high if not higher than FDT2.

Normative Databases for Imaging Instrumentation.

The process for development of imaging reference databases may be improved by standardizing eligibility requirements and data collection protocols. Such standardization may also improve the degree to which results may be compared between commercial instruments.