Montesano Giovanni

Visual Field Outcomes from the Multicenter, Randomized Controlled Laser in Glaucoma and Ocular Hypertension Trial (LiGHT).

A slightly larger proportion of ocular hypertensive and glaucoma patients treated first with medical therapy underwent rapid VF progression compared with those treated first with SLT.

Efficacy of Repeat Selective Laser Trabeculoplasty in Medication-Naive Open-Angle Glaucoma and Ocular Hypertension during the LiGHT Trial.

These exploratory analyses demonstrate that repeat SLT can maintain IOP at or below target IOP in medication-naive OAG and OHT eyes requiring retreatment with at least an equivalent duration of effect to initial laser.

A Comparison between the Compass Fundus Perimeter and the Humphrey Field Analyzer.

Relative diagnostic precision of the 2 devices is equivalent. Test-retest variability of MS for CMP was better than for HFA.

Five-Year Visual Field Outcomes of the HORIZON Trial.

CS-HMS has a significant effect on VF preservation in glaucoma patients compared with CS alone, reducing the proportion of fast progressors.

Policy-Driven, Multimodal Deep Learning for Predicting Visual Fields from the Optic Disc and OCT Imaging.

The multimodal, policy DL model performed the best; it provided explainable maps of its confidence in fusing data from single modalities and provides a pathway for probing the structure-function relationship in glaucoma.

Evaluating the Impact of Uveitis on Visual Field Progression Using Large-Scale Real-World Data.

Our analysis suggests that VF loss occurs faster in glaucoma patients with uveitis than those without uveitis.

Calcium Channel Blocker Use and Associated Glaucoma and Related Traits Among UK Biobank Participants.

In this study, an adverse association between CCB use and glaucoma was observed, with CCB users having, on average, 39% higher odds of glaucoma.

Improving the Power of Glaucoma Neuroprotection Trials Using Existing Visual Field Data.

Selecting patients with low intertest variability can significantly improve the power and reduce the sample size needed in a trial.

Hierarchical Censored Bayesian Analysis of Visual Field Progression.

Bayesian hierarchical models improved the detection of VF progression. Accounting for censoring improves the precision of the estimates, but minimal effect is provided by accounting for heteroskedasticity.

Revisiting the Drasdo Model: Implications for Structure-Function Analysis of the Macular Region.

The Drasdo model can effectively account for AL assuming geometric scaling. Method 2 should be used for structure-function analyses.

Improving Visual Field Examination of the Macula Using Structural Information.

Binary responses can be modeled to incorporate detailed structural information from macular OCT into visual field testing, improving overall speed and accuracy in poor responders.

Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study.

No evidence supports that either diurnal or long-term IOP fluctuation, as measured in clinical practice, are independent factors for glaucoma progression; other aspects of IOP, including mean IOP and peak IOP, may be more informative.

The Impact of Baseline Intraocular Pressure on Initial Treatment Response in the LiGHT Trial: Selective Laser Trabeculoplasty versus Medication.

We confirm previous reports of greater IOP lowering with higher baseline IOP for both SLT and PGA drops.

Visual Field Endpoints for Neuroprotective Trials: A Case for AI-Driven Patient Enrichment.

An AI model can identify high-risk patients to substantially reduce the number of patients needed or study duration required to meet clinical trial endpoints.

Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success.

Hypotony failure criteria are highly heterogenous in the glaucoma literature, with few studies focusing on clinical manifestations.

Two-Year Visual Field Outcomes of the Treatment of Advanced Glaucoma Study (TAGS).

There was no significant difference in the average RoP at 2 years.

Estimating the Distribution of True Rates of Visual Field Progression in Glaucoma.

The distribution of "true" RoPs can be estimated with an exGaussian-LMM, improving model accuracy.

Comparison of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Thickness Values Using Spectral-Domain and Swept-Source OCT.

Thickness values obtained with SD-OCT and SS-OCT are not directly interchangeable but potentially interconvertible. Both devices have a similar ability to discriminate glaucoma patients from GS and healthy subjects.

Validating Trend-Based End Points for Neuroprotection Trials in Glaucoma.

The trend-based methods can efficiently detect treatment effects defined by long-term FDA-compatible progression.

Relationship Between Intraocular Pressure and the True Rate of Functional and Structural Progression in the United Kingdom Glaucoma Treatment Study.

VF appeared to deteriorate at a faster rate than structural measurements. However, this could be explained by the floor-effect from nonfunctional tissue. IOP induced a similar acceleration in RoP per mm Hg increase.

Do Additional Testing Locations Improve the Detection of Macular Perimetric Defects in Glaucoma?

Visual field examinations with additional macular locations can improve the detection of macular defects in GON modestly without loss of specificity when appropriate criteria are selected.

Evaluating High Intraocular Pressure Criteria for Failure in Glaucoma Surgery: Impact on Estimated Success and Visual Field Rates.

The criteria for defining high IOP failure in glaucoma surgery are highly heterogeneous in the current literature.

Spatial Summation in the Glaucomatous Macula: A Link With Retinal Ganglion Cell Damage.

Macular sensitivity loss in glaucoma is better described by a model in which RA changes with RGC loss. Structural measurements have limited dynamic range.

Improving the Accuracy and Speed of Visual Field Testing in Glaucoma With Structural Information and Deep Learning.

DL structure-function predictions from clinically available OCT scans can improve perimetry in glaucoma patients.

Systematic and Random Mapping Errors in Structure - Function Analysis of the Macula.

Rotating the perimetric grid to match the fovea-disc axis is not recommended. Fixation eccentricity and instability should be taken into account for structure-function analyses.

Re: Gedde et al: Special Commentary: Reporting clinical endpoints in studies of minimally invasive glaucoma surgery (Ophthalmology. 2025;132:141-153).

Disease Progression, not Intraocular Pressure, Should Guide Escalation of Treatment in Glaucoma.

Comparison Between 24-2 ZEST and 24-2 ZEST FAST Strategies in Glaucoma and Ocular Hypertension Using a Fundus Perimeter.

ZEST FAST thresholding provides similar results to ZEST with a significantly reduced examination time.

Six-Year Rate of Visual Field Progression in the Laser in Glaucoma and Ocular Hypertension Trial.

First-line SLT was more effective than drops at preserving VF.

On the Feasibility of Accelerating Glaucoma Clinical Trials Using Portable Perimetry.

Home VF assessments, despite poorer reliability than current reference standard ("in-clinic") devices, would allow faster or greater detection of glaucoma progression via an increased frequency of testing, and could reduce the sample size requirements of future clinical trials.

Prediction of repeatable glaucomatous visual field defects based on cluster characteristics.

The location, size and volume of clusters of defects on an initial VF test may be predictive of subsequent repeatability. This may help distinguish eyes with a higher risk of repeatable defects.

Reliability of Self-Monitoring of Intraocular Pressure With iCare Home2 Rebound Tonometry.

Self-measured IOP with rebound tonometry showed good reliability and repeatability when compared with physician-measured IOP with both standard GAT and rebound tonometry.

Validating and Updating the OHTS-EGPS Model Predicting 5-year Glaucoma Risk among Ocular Hypertension Patients Using Electronic Records.

We performed an external validation of the OHTS-EGPS model in a large English population.

A Practical Framework for the Integration of Structural Data Into Perimetric Examinations.

Structurally enhanced perimetric examination can significantly improve test time in healthy subjects and can be delivered through a user-friendly interface. Further testing will need to assess feasibility and performance of S-ZEST in patients with glaucoma.

Archetypes of Binocular Visual Field Loss and Their Impact on Vision-Related Quality of Life in Glaucoma Patients.

Twelve visual field loss archetypes clarify how specific defect patterns impact glaucoma patients' vision-related quality of life. This helps clinicians and patients better understand the functional consequences of different visual field defects.

Comparing the Rate of Retinal Nerve Fiber Layer and Visual Field Loss as Outcomes in Glaucoma Trials.

Using realistic modeling of structure-function progression and test-retest data, MD progression showed higher statistical power cpRFNL as an outcome measure for clinical trials.

Refining Visual Field Trend Progression Criteria in Glaucoma: Impact of Significance Thresholds and Test Frequency.

A substantial proportion of apparent progression at the established P < 0.05 threshold may be falsely positive.

Fields from home: device-independent online perimetry with Melbourne Rapid Fields.

Home-perimetry produced more variable results than in-clinic testing, but the increased testing frequency enabled the potential earlier detection of progression compared to standard in-clinic testing.

Italian glaucoma virtual clinics: Developing a consensus for remote patient management.

This Delphi panel provides guidance for implementing glaucoma virtual clinics in Italy, establishing guidelines on patient selection, required assessments and staffing needs.

Association of Systemic Calcium Channel Blocker Use with Visual Field Progression in a Large Real-World Cohort from Glaucoma Clinics.

Calcium channel blocker use was statistically significantly associated with a slower rate of VF deterioration after multivariable adjustment.

Author Response: The Distribution of True Visual Field Progression Rates in Glaucoma.

Response to: 'Comment on: 'Effect of trabeculectomy on the rate of progression of visual field damage".

Comparison of preservative-free latanoprost and preservative-free bimatoprost in a multicenter, randomized, investigator-masked cross-over clinical trial, the SPORT trial.

This study demonstrates a superior efficacy of BUDPF over LUDPF in lowering IOP.