Antonio Morales‐Esteban

Risk Factors for Fast Visual Field Progression in Glaucoma.

In this cohort, older age, peak IOP, pseudoexfoliative glaucoma, and baseline MD were associated with the rate of glaucomatous VF worsening.

The relationship between central visual field sensitivity and macular ganglion cell/inner plexiform layer thickness in glaucoma.

Macular OCT/VF relationships have localised arcuate characteristics in the central region of the macula.

Longitudinal Macular Structure-Function Relationships in Glaucoma.

Correlations between central structural and functional rates of change were weak to fair in this cohort.

Comparison of Methods to Detect and Measure Glaucomatous Visual Field Progression.

GRI and PoPLR showed the highest proportion of series detected as progressing and shortest times to progression detection. GRI exhibited the best ability to detect progression in the simulated VF series.

Observational Outcomes of Initial Trabeculectomy With Mitomycin C in Patients of African Descent vs Patients of European Descent: Five-Year Results.

African descent was associated with higher failure rates and higher incidence of bleb leaks after initial trabeculectomy with mitomycin C compared with European descent.

Predictors of Long-Term Visual Field Fluctuation in Glaucoma Patients.

This study identified novel predictors of VF fluctuation, and explains nearly 60% of the pointwise variance.

Cataract Surgery and Rate of Visual Field Progression in Primary Open-Angle Glaucoma.

Although all IOP parameters improved after cataract surgery, VFs continued to progress. Cataract surgery does not slow the apparent rate of glaucomatous VF decay as compared to rates measured during the progression of the cataract.

Quantification of Visual Field Variability in Glaucoma: Implications for Visual Field Prediction and Modeling.

VF variability increases with the severity of glaucoma damage and decreases with eccentricity.

Trabeculectomy With Mitomycin-C: Outcomes and Risk Factors for Failure in Primary Angle-closure Glaucoma.

The qualified success rates (±SD) after 1, 3, and 5 years of follow-up for criterion A were 92% (±2.2%), 78% (±3.8%), and 72% (±4.3%); for criterion B, 86% (±3.0%), 65% (±4.4%), and 59% (±4.7%); and…

A Method to Measure the Rate of Glaucomatous Visual Field Change.

GRI provides a robust measure of glaucomatous VF change, operates without discontinuity over the entire perimetric range, and can be used to identify fast progressors.

Prediction of Visual Field Progression with Baseline and Longitudinal Structural Measurements Using Deep Learning.

DL model predicted VF progression with clinically relevant accuracy using baseline RNFL thickness and serial ODPs and can be implemented as a clinical tool after further validation.

Comparison of Rates of Progression of Macular OCT Measures in Glaucoma.

GCC measurements are most likely to detect structural worsening along the spectrum of glaucoma severity. Although FMT rates of change are least influenced by baseline thickness, they partially reflect likely age-related ORL changes.

Vertical Macular Asymmetry Measures Derived From SD-OCT for Detection of Early Glaucoma.

Macular vertical thickness asymmetry measures did not perform better than sectoral or minimum GCIPL thickness for detection of early glaucoma. Combining local asymmetry parameters with the best sectoral GCIPL thickness measures enhanced this task.

Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success.

Hypotony failure criteria are highly heterogenous in the glaucoma literature, with few studies focusing on clinical manifestations.

Long-term Outcome of Second Ahmed Valves in Adult Glaucoma.

A second AGV is effective in reducing IOP in patients who require additional IOP lowering after a first AGV.

Detection of Longitudinal Ganglion Cell/Inner Plexiform Layer Change: Comparison of Two Spectral-Domain Optical Coherence Tomography Devices.

Changes in macular GCIPL were detected more frequently on Spectralis' longitudinal volume scans than those of Cirrus OCT. OCT devices are not interchangeable with regard to detection of macular structural progression.

Local Macular Thickness Relationships between 2 OCT Devices.

Local macular thickness measurements from the Spectralis and Cirrus devices are highly correlated, but not interchangeable. Differences in thickness measurements between the two devices are influenced by the location of superpixels and their thickness.

Pointwise Methods to Measure Long-term Visual Field Progression in Glaucoma.

These results suggest GRI can detect long-term VF progression in glaucoma earlier than PLR or GPA. Validation with prospective designs may strengthen the generalizability and value of this method.

The Trajectory of Glaucoma Progression in 2-Dimensional Structural-Functional Space.

We report a method to visualize the trajectory of a patient's glaucoma progression in a 2-dimensional S-F space. The slope of the trajectory of glaucoma progression is a function of the severity of the disease.

Expert Evaluation of Visual Field Decay in Glaucoma Correlates With the Fast Component of Visual Field Loss.

Expert qualitative evaluation of field series for change and rate of change correlate more closely with the fast component than with the slow component of VF decay.

Evaluating High Intraocular Pressure Criteria for Failure in Glaucoma Surgery: Impact on Estimated Success and Visual Field Rates.

The criteria for defining high IOP failure in glaucoma surgery are highly heterogeneous in the current literature.

Long-Term Visual Field Outcomes After Ahmed Glaucoma Valve Implantation.

To our knowledge, this is the largest published series reporting long-term VF outcomes after glaucoma drainage device implantation. There is a continued, significant rate of VF decline after AGV surgery.

Long-Term Rate of Optic Disc Rim Loss in Glaucoma Patients Measured From Optic Disc Photographs With a Deep Neural Network.

Automated calculation of RADAR and DDLS with a neural network can be used to evaluate the extent and long-term rate of optic disc rim loss and is further evidence of long-term nerve fiber loss in…

A Metascore of Multiple Imaging Methods to Measure Long-Term Glaucoma Structural Progression.

We report a method that converts Cirrus global RNFL and HRT global rim area normalized measurements to Spectralis global RNFL equivalent values to facilitate long-term structural follow-up.

Structural-Functional Glaucoma Progression Trajectory in 2-Dimensional Space.

We present a method that presents glaucoma progression in a 2D S/F space.

The Incidence of Clinically Significant Hypotony after Trabeculectomy.

A minority of eyes (20.1%) with numerical hypotony showed clinical manifestations of low IOP. Asian ethnicity and eyes that required suture lysis postoperatively tended to have less incidence of clinical sequelae of hypotony after trabeculectomy.

An Artificial Intelligence-Based Prognostic Model for Prediction of Functional Glaucoma Progression From Clinical and Structural Data.

Our newly designed deep learning model can combine baseline demographic and clinical data with widely available structural measurements and provide clinically relevant information for the prediction of glaucoma progression.

3D integrated approach to structural and functional monitoring in glaucoma.

The 3D trajectory model visualises distinct progression patterns, with structural changes preceding functional decline in earlier stages and functional-only progression dominating in advanced stages.

Predictors of Glaucomatous Progression in Individuals with Small and Large Optic Discs.

Increased odds of glaucomatous progression were associated with Asian vs.

Author Response: Comparison of Local Structure-Function Relationships and Dynamic Range in Glaucoma.

Detection of Structural Glaucoma Progression with Deep Learning on Serial Optic Disc Photographs.

A deep learning model accurately detected glaucoma progression from serial optic disc photographs with high sensitivity. This offers a promising adjunctive tool for clinical decision-making in structural glaucoma monitoring.

Prediction of visual field progression with serial optic disc photographs using deep learning.

A deep learning model can predict subsequent glaucoma progression from longitudinal ODPs with clinically relevant accuracy. This model may be implemented, after validation, for predicting glaucoma progression in the clinical setting.

Phenotypic expressions of the optic disc in primary open-angle glaucoma.

We report six phenotypic classifications of POAG patients with demographic and ocular differences between phenotypes. Future refinement of phenotypes should allow enhanced identification of genetic associations and improved individualization of patient care.

Same-site Trabeculectomy Revision for Failed Trabeculectomy: Outcomes and Risk Factors for Failure.

Given the long-term tonometric success rates along with significant medication reduction, same-site trabeculectomy revision with MMC should be considered as a viable option to achieve reasonable IOP targets after a first failed trabeculectomy in open-angle…

Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range.

GCIPL, GCL, and GCC demonstrated comparable SF relationships while FT, GCC, and GCIPL had the widest dynamic range.

Trabeculectomy and Combined Phacoemulsification-Trabeculectomy: Outcomes and Risk Factors for Failure in Primary Angle Closure Glaucoma.

In phakic patients with PACG, trabeculectomy with MMC significantly reduces IOP and number of glaucoma medications at 12 months without change in visual acuity.

Course of Glaucomatous Visual Field Loss Across the Entire Perimetric Range.

Pointwise sigmoid regression had a better ability to fit perimetric decay into a subset of locations that traverse the entire range of perimetric measurements from near normal to near perimetric blindness compared with linear and exponential functions.

Enhancement of Visual Field Predictions with Pointwise Exponential Regression (PER) and Pointwise Linear Regression (PLR).

Smoothed VF data predicted better than unsmoothed data. Nearest neighbor provided the best predictions; PER also predicted consistently more accurately than PLR. Smoothing algorithms should be used when forecasting VF results with PER or PLR.

Trabeculectomy Can Improve Long-Term Visual Function in Glaucoma.

The results show that trabeculectomy slows the rate of perimetric decay and provide evidence of sustained, long-term improvement of visual function in glaucoma.

The Fast Component of Visual Field Decay Rate Correlates With Disc Rim Area Change Throughout the Entire Range of Glaucomatous Damage.

A decrease in rim area was significantly correlated with the fast VF component regardless of the baseline severity of glaucoma.