Structural-Functional Glaucoma Progression Trajectory in 2-Dimensional Space.

PRCIS

We describe a method that provides rapid visualization of glaucomatous change in a 2-dimensional (2D) structural and functional (S/F) space.

PURPOSE

To describe a method to visualize glaucomatous change in a 2D S/F space.

DESIGN

This was a retrospective longitudinal observational study.

SUBJECTS

Group I included 64 normal and 64 glaucomatous eyes used to develop the structural score. Group II included 957 glaucomatous eyes used to plot the structural-functional progression vectors.

METHODS

Subjects were arranged in 2 groups. Group I was a cross-sectional group used to develop a structural score which were applied to longitudinal measurements of patients in group II for vectoral analysis. Visual field index was used as a functional score. Vectors were created for each eye to define structural (x) and functional (y) progression. The structural and functional components were calculated with linear models of optical coherence tomography scores and visual field index. The resultant vector and its confidence interval were plotted in 2D S/F space.

MAIN OUTCOME MEASURES

Combined structural-functional glaucomatous progression.

RESULTS

Group I included 64 normal and 64 glaucomatous eyes. We calculated 957 vectors (957 eyes of 582 OAG patients) in group II. The mean (±SD) follow-up period was 6.9 (±1.5) years and mean baseline mean deviation (MD) was -4.3 (±5.4). Preperimetric, mild, moderate, and severe groups included 159, 288, 299, and 211 eyes, respectively. Mean baseline MDs in these groups were 0.8, -1.0, -3.7, and -11.2 dB, and mean vector slopes were 0.88, 1.00, 1.98, and 2.69.

CONCLUSION

We present a method that presents glaucoma progression in a 2D S/F space. This approach integrates a large amount of longitudinal numerical data and provides the clinician with a rapid and intuitive summary of the patient's glaucoma trajectory.