Caprioli Joseph

Risk Factors for Fast Visual Field Progression in Glaucoma.

In this cohort, older age, peak IOP, pseudoexfoliative glaucoma, and baseline MD were associated with the rate of glaucomatous VF worsening.

Magnetic Resonance Imaging of Optic Nerve Traction During Adduction in Primary Open-Angle Glaucoma With Normal Intraocular Pressure.

Although tethering and elongation of ON and sheath are normal in adduction, adduction is associated with abnormally great globe retraction in POAG without elevated IOP.

The relationship between central visual field sensitivity and macular ganglion cell/inner plexiform layer thickness in glaucoma.

Macular OCT/VF relationships have localised arcuate characteristics in the central region of the macula.

Longitudinal Macular Structure-Function Relationships in Glaucoma.

Correlations between central structural and functional rates of change were weak to fair in this cohort.

Comparison of Methods to Detect and Measure Glaucomatous Visual Field Progression.

GRI and PoPLR showed the highest proportion of series detected as progressing and shortest times to progression detection. GRI exhibited the best ability to detect progression in the simulated VF series.

Risk Factors and Long-Term Outcomes in Patients with Low Intraocular Pressure after Trabeculectomy.

The absence of laser suture lysis and surgeon are factors potentially associated with low IOP after trabeculectomy. Numeric hypotony does not necessarily represent clinical failure after trabeculectomy.

Association of Structural and Functional Measures With Contrast Sensitivity in Glaucoma.

Structural and functional measures showed a fair relationship with contrast sensitivity.

Prediction of Visual Field Progression from OCT Structural Measures in Moderate to Advanced Glaucoma.

VF progression can be predicted with clinically relevant accuracy from baseline and longitudinal structural data. Further refinement of proposed models would assist clinicians with timely prediction of functional glaucoma progression and clinical decision making.

Factors Influencing Central Lamina Cribrosa Depth: A Multicenter Study.

Central LD was deeper in African descent eyes and influenced least by age, axial length, and sex, but more by ASCO area, when measured relative to the ASCO and sclera.

Association of Dietary Fatty Acid Intake With Glaucoma in the United States.

Increased daily dietary consumption levels of eicosapentaenoic acid and docosahexaenoic acid were associated with lower likelihood of glaucomatous optic neuropathy.

Aqueous Angiography with Fluorescein and Indocyanine Green in Bovine Eyes.

Aqueous angiography in model cow eyes demonstrated segmental angiographic outflow patterns with either fluorescein or ICG as a tracer.

Observational Outcomes of Initial Trabeculectomy With Mitomycin C in Patients of African Descent vs Patients of European Descent: Five-Year Results.

African descent was associated with higher failure rates and higher incidence of bleb leaks after initial trabeculectomy with mitomycin C compared with European descent.

Peripapillary Scleral Bowing Increases with Age and Is Inversely Associated with Peripapillary Choroidal Thickness in Healthy Eyes.

In non-highly myopic healthy eyes, outward peripapillary scleral bowing achieved substantial levels, was markedly increased with age, and was independently associated with decreased peripapillary choroidal thickness.

Predictors of Long-Term Visual Field Fluctuation in Glaucoma Patients.

This study identified novel predictors of VF fluctuation, and explains nearly 60% of the pointwise variance.

Cataract Surgery and Rate of Visual Field Progression in Primary Open-Angle Glaucoma.

Although all IOP parameters improved after cataract surgery, VFs continued to progress. Cataract surgery does not slow the apparent rate of glaucomatous VF decay as compared to rates measured during the progression of the cataract.

Comparison of Endothelial Keratoplasty Techniques in Patients With Prior Glaucoma Surgery: A Case-Matched Study.

In complex eyes with prior glaucoma surgery, DMEK offers faster visual recovery, better final visual acuity, and a lower rate of secondary graft failure compared to DSEK during the first postoperative year and beyond.

Quantification of Visual Field Variability in Glaucoma: Implications for Visual Field Prediction and Modeling.

VF variability increases with the severity of glaucoma damage and decreases with eccentricity.

Structure-Function Relationships in Perimetric Glaucoma: Comparison of Minimum-Rim Width and Retinal Nerve Fiber Layer Parameters.

Structure-function relationships were somewhat weaker with BMO-MRW parameters compared with pRNFL in eyes with perimetric glaucoma.

Trabeculectomy With Mitomycin-C: Outcomes and Risk Factors for Failure in Primary Angle-closure Glaucoma.

The qualified success rates (±SD) after 1, 3, and 5 years of follow-up for criterion A were 92% (±2.2%), 78% (±3.8%), and 72% (±4.3%); for criterion B, 86% (±3.0%), 65% (±4.4%), and 59% (±4.7%); and…

A Method to Measure the Rate of Glaucomatous Visual Field Change.

GRI provides a robust measure of glaucomatous VF change, operates without discontinuity over the entire perimetric range, and can be used to identify fast progressors.

Prediction of Glaucoma Progression with Structural Parameters: Comparison of Optical Coherence Tomography and Clinical Disc Parameters.

Baseline structural OCT measures predicted subsequent VF progression in contrast to semi-quantitative optic disc measures. OCT-based structural measures should be included in prognostic models of glaucomatous VF deterioration.

Prediction of Visual Field Progression with Baseline and Longitudinal Structural Measurements Using Deep Learning.

DL model predicted VF progression with clinically relevant accuracy using baseline RNFL thickness and serial ODPs and can be implemented as a clinical tool after further validation.

Long-Term Outcomes of Descemet Membrane Endothelial Keratoplasty in Eyes with Prior Glaucoma Surgery.

In eyes with prior glaucoma surgery, DMEK achieved good long-term visual outcomes but experienced a higher rate of SGF than eyes without such comorbidity.

Longitudinal Macular Structure-Function Relationships in Glaucoma and Their Sources of Variability.

Within-session variability accounts for most of macular thickness variability over time.

Comparison of Rates of Progression of Macular OCT Measures in Glaucoma.

GCC measurements are most likely to detect structural worsening along the spectrum of glaucoma severity. Although FMT rates of change are least influenced by baseline thickness, they partially reflect likely age-related ORL changes.

Vertical Macular Asymmetry Measures Derived From SD-OCT for Detection of Early Glaucoma.

Macular vertical thickness asymmetry measures did not perform better than sectoral or minimum GCIPL thickness for detection of early glaucoma. Combining local asymmetry parameters with the best sectoral GCIPL thickness measures enhanced this task.

Comparison of Ganglion Cell Layer and Ganglion Cell/Inner Plexiform Layer Measures for Detection of Early Glaucoma.

Macular GCL and GCIPL thicknesses are equivalent for identifying early glaucoma with current OCT technology.

Glaucoma After Iodine-125 Brachytherapy for Uveal Melanoma: Incidence and Risk Factors.

We have identified additional risk factors for the development of both secondary open-angle glaucoma and neovascular glaucoma in patients with uveal melanoma who have undergone iodine-125 brachytherapy for local tumor control.

Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success.

Hypotony failure criteria are highly heterogenous in the glaucoma literature, with few studies focusing on clinical manifestations.

Estimating Ganglion Cell Complex Rates of Change With Bayesian Hierarchical Models.

A Bayesian linear hierarchical model with random intercepts/slopes and random variances is an optimal initial model for estimating GCC slopes at population and individual levels.

Association of Blood Pressure With Rates of Macular Ganglion Cell Complex Thinning in Patients With Glaucoma.

In this cohort study, a combination of lower diastolic blood pressure and higher intraocular pressure at baseline was associated with faster rates of ganglion cell complex thinning.

Ganglion Cell Complex: The Optimal Measure for Detection of Structural Progression in the Macula.

GCC is the optimal macular measure for detection of structural change in eyes with moderate to severe glaucoma.

Long-term Outcome of Second Ahmed Valves in Adult Glaucoma.

A second AGV is effective in reducing IOP in patients who require additional IOP lowering after a first AGV.

Associations Between Niacin Intake and Glaucoma in the National Health and Nutrition Examination Survey.

In the 2005-2008 NHANES population, higher levels of niacin intake were associated with decreased odds of glaucoma overall and in women.

Comparison of Ganglion Cell Layer and Inner Plexiform Layer Rates of Change in Suspected and Established Glaucoma.

GCL thickness is more likely to demonstrate change over time compared with IPL in glaucoma suspects. There is no evidence of preferential IPL thinning in eyes with suspected early glaucoma damage.

Strabismus After Ahmed Glaucoma Valve Implantation.

We identified 29 patients who developed new-onset strabismus postoperatively after initial AGV implantation, for 4% incidence of strabismus.

Trabeculectomy Outcomes After Glaucoma Drainage Device Surgery.

Trabeculectomy is a viable surgical option to treat IOP that is uncontrolled after GDD implantation.

Relationship of the Macular Ganglion Cell and Inner Plexiform Layers in Healthy and Glaucoma Eyes.

Ethnicity and distance from the fovea are the main determinants of IPL thickness in the central macula.

A Phenotype of Primary Open-angle Glaucoma With Systemic Vasospasm.

We describe a POAG subtype with APON and systemic vascular instability, predominantly female in their sixth decade of life who demonstrate progressive glaucomatous visual field damage at low intraocular pressure.

Comparing Rates of Change in Moderate to Advanced Glaucoma: Retinal Nerve Fiber Layer Versus Bruch Membrane Opening-Minimum Rim Width.

Longitudinal RNFL OCT measurements are more likely to detect structural change and demonstrate better LSNR compared with BMO-MRW in eyes with central or moderate-to-advanced glaucoma damage at baseline.

Detection of Longitudinal Ganglion Cell/Inner Plexiform Layer Change: Comparison of Two Spectral-Domain Optical Coherence Tomography Devices.

Changes in macular GCIPL were detected more frequently on Spectralis' longitudinal volume scans than those of Cirrus OCT. OCT devices are not interchangeable with regard to detection of macular structural progression.

Local Macular Thickness Relationships between 2 OCT Devices.

Local macular thickness measurements from the Spectralis and Cirrus devices are highly correlated, but not interchangeable. Differences in thickness measurements between the two devices are influenced by the location of superpixels and their thickness.

Pointwise Methods to Measure Long-term Visual Field Progression in Glaucoma.

These results suggest GRI can detect long-term VF progression in glaucoma earlier than PLR or GPA. Validation with prospective designs may strengthen the generalizability and value of this method.

Combining Structural and Vascular Parameters to Discriminate Among Glaucoma Patients, Glaucoma Suspects, and Healthy Subjects.

Combining structural and vascular parameters in a structural-vascular index does not improve diagnostic ability over structural parameters alone.

Demographic, Comorbid, and Clinical Variables Associated With Pointwise Visual Field Damage in Glaucoma: Data From the AGIS and CIGTS Clinical Trials.

The approach used provides new longitudinal and cross-sectional insights into variation across the VF associated with demographic, comorbid, and clinical variables.

The Trajectory of Glaucoma Progression in 2-Dimensional Structural-Functional Space.

We report a method to visualize the trajectory of a patient's glaucoma progression in a 2-dimensional S-F space. The slope of the trajectory of glaucoma progression is a function of the severity of the disease.

Expert Evaluation of Visual Field Decay in Glaucoma Correlates With the Fast Component of Visual Field Loss.

Expert qualitative evaluation of field series for change and rate of change correlate more closely with the fast component than with the slow component of VF decay.

Evaluating High Intraocular Pressure Criteria for Failure in Glaucoma Surgery: Impact on Estimated Success and Visual Field Rates.

The criteria for defining high IOP failure in glaucoma surgery are highly heterogeneous in the current literature.

Outcomes of Trabeculectomy With Mitomycin C in Patients of Hispanic vs European Descent.

In this study, Hispanic descent was associated with higher failure rate after initial trabeculectomy with adjunctive MMC compared with European descent.

Association of Blood Pressure and Retinal Nerve Fiber Layer Rates of Thinning in Patients with Moderate to Advanced Glaucoma.

Low BP and higher IOP at baseline predicted faster (worse) RNFL RoCs in glaucoma patients with central damage or moderate to advanced disease.

Long-Term Visual Field Outcomes After Ahmed Glaucoma Valve Implantation.

To our knowledge, this is the largest published series reporting long-term VF outcomes after glaucoma drainage device implantation. There is a continued, significant rate of VF decline after AGV surgery.

The Success Rate of Glaucoma Drainage Device Revision.

These results suggest that eyes with glaucomatous damage with long-term glaucoma drainage device complications can still have a reasonably successful outcome when a revision is performed.

Efficacy of Combined Suprachoroidal Stent and Cataract Surgery in Patients With Glaucoma.

Combined CyPass Micro-Stent implantation and cataract surgery may reduce glaucoma medication burden with a success rate of 28% to 42% at 1 year.

Optic Disc Image Subtraction as an Aid to Detect Glaucoma Progression.

The proposed software provides a single static image that clinicians can use with other structural/functional tests to detect glaucoma progression.

Re: Gedde et al: Special Commentary: Reporting clinical endpoints in studies of minimally invasive glaucoma surgery (Ophthalmology. 2025;132:141-153).

Detecting Fast Progressors: Comparing a Bayesian Longitudinal Model to Linear Regression for Detecting Structural Changes in Glaucoma.

The Bayesian HSL model improves the estimation efficiency of local GCC rates of change regardless of underlying true rates of change, particularly in fast progressors.

A Bayesian Hierarchical Spatial Longitudinal Model Improves Estimation of Local Macular Rates of Change in Glaucomatous Eyes.

A novel Bayesian HSL model improves estimation accuracy of patient-specific local GCC rates of change.

Long-term Treatment Outcomes for Malignant Glaucoma.

Female gender, PACG, and glaucoma surgery were predisposing factors for the development of MG.

Central Macular Topographic and Volumetric Measures: New Biomarkers for Detection of Glaucoma.

Novel macular shape biomarkers detect early glaucoma with clinically relevant performance. Such biomarkers do not depend on intraretinal segmentation accuracy and may be helpful in eyes with suboptimal macular segmentation.

Orbital Fat Volume After Treatment with Topical Prostaglandin Agonists.

Patients with POAG who have been treated with PGAs have lower overall OFV than controls, but OFV in the anterior orbit is similar in both groups.

Protruded retinal layers within the optic nerve head neuroretinal rim.

Protruded retinal layers are a component of MRW measurements in most normal subjects, occurring in almost 12% of all measurement points analysed.

Retinal Nerve Fiber Layer Rates of Change: Comparison of 2 OCT Devices.

Spectralis OCT rates of RNFL change were faster compared to those from Cirrus OCT.

Comparison of Retinal Nerve Fiber Layer and Ganglion Cell Complex Rates of Change in Patients With Moderate to Advanced Glaucoma.

Both GCC and RNFL measures can detect structural progression in glaucoma patients with central damage or moderate to advanced glaucoma. The clinical utility of RNFL imaging decreases with worsening severity of glaucoma.

A Health-Related Quality of Life Measure for Patients Who Undergo Minimally Invasive Glaucoma Surgery.

This study supports using the GOS for ophthalmic procedures such as MIGS. Further evaluation of the GOS in different patient subgroups and clinical settings is needed.

Long-Term Rate of Optic Disc Rim Loss in Glaucoma Patients Measured From Optic Disc Photographs With a Deep Neural Network.

Automated calculation of RADAR and DDLS with a neural network can be used to evaluate the extent and long-term rate of optic disc rim loss and is further evidence of long-term nerve fiber loss in…

A Metascore of Multiple Imaging Methods to Measure Long-Term Glaucoma Structural Progression.

We report a method that converts Cirrus global RNFL and HRT global rim area normalized measurements to Spectralis global RNFL equivalent values to facilitate long-term structural follow-up.

Structural-Functional Glaucoma Progression Trajectory in 2-Dimensional Space.

We present a method that presents glaucoma progression in a 2D S/F space.

Re: Saeedi et al: Agreement and predictors of discordance of 6 visual field progression algorithms (Ophthalmology. 2019;126:822-828).

Visual Field Assessment in Children.

The Incidence of Clinically Significant Hypotony after Trabeculectomy.

A minority of eyes (20.1%) with numerical hypotony showed clinical manifestations of low IOP. Asian ethnicity and eyes that required suture lysis postoperatively tended to have less incidence of clinical sequelae of hypotony after trabeculectomy.

An Artificial Intelligence-Based Prognostic Model for Prediction of Functional Glaucoma Progression From Clinical and Structural Data.

Our newly designed deep learning model can combine baseline demographic and clinical data with widely available structural measurements and provide clinically relevant information for the prediction of glaucoma progression.

3D integrated approach to structural and functional monitoring in glaucoma.

The 3D trajectory model visualises distinct progression patterns, with structural changes preceding functional decline in earlier stages and functional-only progression dominating in advanced stages.

A Bayesian Hierarchical Longitudinal Model for Estimation of Central Visual Field Rates of Change in Glaucoma.

When baseline pointwise sensitivity is 5 to 20 dB, residual variability is very large, substantially reducing the ability to detect glaucoma progression.

Telemedicine in Glaucoma Management: Patient Perspectives.

This study demonstrates high satisfaction and support for integrated telemedicine visits among glaucoma patients within a specialized practice setting.

Eye Movements and the Intraorbital Subarachnoid Space: Potential Contribution of Altered Cerebrospinal Fluid Pumping in Optic Neuropathies.

Horizontal gaze and supraduction change subarachnoid CSF volume around the retrobulbar ON.

Predictors of Glaucomatous Progression in Individuals with Small and Large Optic Discs.

Increased odds of glaucomatous progression were associated with Asian vs.

Cataract Surgery and Rate of Visual Field Progression in Primary Open-Angle Glaucoma.

Author Response: Comparison of Local Structure-Function Relationships and Dynamic Range in Glaucoma.

Detection of Structural Glaucoma Progression with Deep Learning on Serial Optic Disc Photographs.

A deep learning model accurately detected glaucoma progression from serial optic disc photographs with high sensitivity. This offers a promising adjunctive tool for clinical decision-making in structural glaucoma monitoring.

Prediction of visual field progression with serial optic disc photographs using deep learning.

A deep learning model can predict subsequent glaucoma progression from longitudinal ODPs with clinically relevant accuracy. This model may be implemented, after validation, for predicting glaucoma progression in the clinical setting.

Phenotypic expressions of the optic disc in primary open-angle glaucoma.

We report six phenotypic classifications of POAG patients with demographic and ocular differences between phenotypes. Future refinement of phenotypes should allow enhanced identification of genetic associations and improved individualization of patient care.

Same-site Trabeculectomy Revision for Failed Trabeculectomy: Outcomes and Risk Factors for Failure.

Given the long-term tonometric success rates along with significant medication reduction, same-site trabeculectomy revision with MMC should be considered as a viable option to achieve reasonable IOP targets after a first failed trabeculectomy in open-angle…

Trabeculectomy and Combined Phacoemulsification-Trabeculectomy: Outcomes and Risk Factors for Failure in Primary Angle Closure Glaucoma.

In phakic patients with PACG, trabeculectomy with MMC significantly reduces IOP and number of glaucoma medications at 12 months without change in visual acuity.

Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range.

GCIPL, GCL, and GCC demonstrated comparable SF relationships while FT, GCC, and GCIPL had the widest dynamic range.

Local Variability of Macular Thickness Measurements With SD-OCT and Influencing Factors.

Local variability of macular SD-OCT measurements is low and uniform across the macula. The relationship between superpixel thickness and outlier proportion varied as a function of the parameter of interest.

Heat shock proteins in the retina: Focus on HSP70 and alpha crystallins in ganglion cell survival.

RGCs survival was also stimulated by overexpression of alpha A and alpha B crystallins.

Course of Glaucomatous Visual Field Loss Across the Entire Perimetric Range.

Pointwise sigmoid regression had a better ability to fit perimetric decay into a subset of locations that traverse the entire range of perimetric measurements from near normal to near perimetric blindness compared with linear and exponential functions.

Enhancement of Visual Field Predictions with Pointwise Exponential Regression (PER) and Pointwise Linear Regression (PLR).

Smoothed VF data predicted better than unsmoothed data. Nearest neighbor provided the best predictions; PER also predicted consistently more accurately than PLR. Smoothing algorithms should be used when forecasting VF results with PER or PLR.

The Relationship of the Clinical Disc Margin and Bruch's Membrane Opening in Normal and Glaucoma Subjects.

Clinical disc area was larger than BMOA in normal and glaucoma eyes but reached statistical significance only in the former group.

Early Aqueous Suppressant Therapy on Hypertensive Phase Following Glaucoma Drainage Device Procedure: A Randomized Prospective Trial.

Aqueous suppression initiated in the early postoperative period while IOPs were still in the low-teens and was able to reduce the incidence of IOP spike associated with the HP without an increased complication rate.

Trabeculectomy Can Improve Long-Term Visual Function in Glaucoma.

The results show that trabeculectomy slows the rate of perimetric decay and provide evidence of sustained, long-term improvement of visual function in glaucoma.

Evaluation of the "IS" Rule to Differentiate Glaucomatous Eyes From Normal.

The ISNT rule alone has a high sensitivity but relatively low specificity.

Location of Initial Visual Field Defects in Glaucoma and Their Modes of Deterioration.

The initial location and subsequent direction of worsening of VFD were associated with different systemic and ocular factors.

Special Commentary: Supporting Innovation for Safe and Effective Minimally Invasive Glaucoma Surgery: Summary of a Joint Meeting of the American Glaucoma Society and the Food and Drug Administration, Washington, DC, February 26, 2014.

Valved Glaucoma Drainage Devices in Pediatric Glaucoma: Retrospective Long-term Outcomes.

Glaucoma drainage devices, such as the Ahmed glaucoma valve, have moderate long-term success rates in pediatric patients with glaucoma.

The Fast Component of Visual Field Decay Rate Correlates With Disc Rim Area Change Throughout the Entire Range of Glaucomatous Damage.

A decrease in rim area was significantly correlated with the fast VF component regardless of the baseline severity of glaucoma.

Prospective Evaluation of Acupuncture as Treatment for Glaucoma.

Acupuncture has no overall effect on diurnal IOP or BCVA but may temporally increase the IOP immediately after a treatment session.

Measuring rates of structural and functional change in glaucoma.

The authors discuss the relevant issues and the inherent caveats related to estimating structural and functional rates of change in glaucoma.

Long-Term Bleb-Related Infections After Trabeculectomy: Incidence, Risk Factors, and Influence of Bleb Revision.

This large case series with long-term follow-up demonstrates the incidence of bleb-related infections to be less than 2%, and describes the risk factors associated with bleb-related infections.

Reply: To PMID 24874999.

The effect of corneal biomechanical properties on rebound tonometer in patients with normal-tension glaucoma.

Since ICare is a convenient way to measure IOP, ICare is a reasonable option as an alternative tonometer in NTG patients.