Fei Yu

Risk Factors for Fast Visual Field Progression in Glaucoma.

In this cohort, older age, peak IOP, pseudoexfoliative glaucoma, and baseline MD were associated with the rate of glaucomatous VF worsening.

Outcomes of Descemet Membrane Endothelial Keratoplasty in Patients With Previous Glaucoma Surgery.

DMEK in eyes with previous trabeculectomy and drainage device can result in very good short-term outcomes.

The relationship between central visual field sensitivity and macular ganglion cell/inner plexiform layer thickness in glaucoma.

Macular OCT/VF relationships have localised arcuate characteristics in the central region of the macula.

Safety of Concurrent Boston Type I Keratoprosthesis and Glaucoma Drainage Device Implantation.

Compared with KPro alone, GDD placement combined with KPro was not associated with increased postoperative complications.

Comparison of Methods to Detect and Measure Glaucomatous Visual Field Progression.

GRI and PoPLR showed the highest proportion of series detected as progressing and shortest times to progression detection. GRI exhibited the best ability to detect progression in the simulated VF series.

Risk Factors and Long-Term Outcomes in Patients with Low Intraocular Pressure after Trabeculectomy.

The absence of laser suture lysis and surgeon are factors potentially associated with low IOP after trabeculectomy. Numeric hypotony does not necessarily represent clinical failure after trabeculectomy.

Association of Dietary Fatty Acid Intake With Glaucoma in the United States.

Increased daily dietary consumption levels of eicosapentaenoic acid and docosahexaenoic acid were associated with lower likelihood of glaucomatous optic neuropathy.

Frequency of a diagnosis of glaucoma in individuals who consume coffee, tea and/or soft drinks.

In NHANES, participants who consumed hot tea daily were less likely to have glaucoma than those who did not consume hot tea.

Predictors of Long-Term Visual Field Fluctuation in Glaucoma Patients.

This study identified novel predictors of VF fluctuation, and explains nearly 60% of the pointwise variance.

Cataract Surgery and Rate of Visual Field Progression in Primary Open-Angle Glaucoma.

Although all IOP parameters improved after cataract surgery, VFs continued to progress. Cataract surgery does not slow the apparent rate of glaucomatous VF decay as compared to rates measured during the progression of the cataract.

Comparison of Endothelial Keratoplasty Techniques in Patients With Prior Glaucoma Surgery: A Case-Matched Study.

In complex eyes with prior glaucoma surgery, DMEK offers faster visual recovery, better final visual acuity, and a lower rate of secondary graft failure compared to DSEK during the first postoperative year and beyond.

Quantification of Visual Field Variability in Glaucoma: Implications for Visual Field Prediction and Modeling.

VF variability increases with the severity of glaucoma damage and decreases with eccentricity.

Overdiagnosis of open-angle glaucoma in the general population: the Thessaloniki Eye Study.

The overdiagnosis of OAG was substantial in this elderly, Caucasian population. The overdiagnosis of glaucoma has not been previously addressed in population-based studies and needs to be further explored.

Twelve-Year Incidence and Baseline Risk Factors for Pseudoexfoliation: The Thessaloniki Eye Study (An American Ophthalmological Society Thesis).

This is one of the very few longitudinal population-based studies that has specifically assessed the incidence of PEX.

Factors Associated With Retinal Vessel Diameters in an Elderly Population: the Thessaloniki Eye Study.

Our study confirms previous reports about the association of age and BP with vessel diameters.

A Method to Measure the Rate of Glaucomatous Visual Field Change.

GRI provides a robust measure of glaucomatous VF change, operates without discontinuity over the entire perimetric range, and can be used to identify fast progressors.

Long-Term Outcomes of Descemet Membrane Endothelial Keratoplasty in Eyes with Prior Glaucoma Surgery.

In eyes with prior glaucoma surgery, DMEK achieved good long-term visual outcomes but experienced a higher rate of SGF than eyes without such comorbidity.

Vertical Macular Asymmetry Measures Derived From SD-OCT for Detection of Early Glaucoma.

Macular vertical thickness asymmetry measures did not perform better than sectoral or minimum GCIPL thickness for detection of early glaucoma. Combining local asymmetry parameters with the best sectoral GCIPL thickness measures enhanced this task.

Association between Exercise Intensity and Glaucoma in the National Health and Nutrition Examination Survey.

In the 2005-2006 NHANES adult population, increased exercise intensity is associated with decreased odds of glaucoma. Further population-based studies are needed to examine associations between additional aspects of exercise and glaucoma.

Social Vulnerability, Prevalence of Glaucoma, and Incidence of Glaucoma Surgery in the California Medicare Population.

In the 2019 California Medicare population, there were variable associations between SVI score, prevalence of glaucoma, and incidence of glaucoma surgery.

Association Between Myopia and Primary Open-Angle Glaucoma by Race and Ethnicity in Older Adults in the California Medicare Population.

In the 2019 California Medicare population, myopia was associated with greater adjusted odds of POAG.

Risk of Glaucoma Surgery After Corneal Transplant Surgery in Medicare Patients.

Despite literature suggesting that more angle-altering cornea surgeries confer higher risk, we found no statistically significant differences among various transplant groups.

Disparities in Glaucoma Surgery: A Review of Current Evidence and Future Directions for Improvement.

Disparities in glaucoma surgery have been examined in large scale datasets, retrospective clinical studies, and clinical trials, and several studies have identified likely racial and ethnic disparities in glaucoma surgical incidence and outcomes.

Associations Between Niacin Intake and Glaucoma in the National Health and Nutrition Examination Survey.

In the 2005-2008 NHANES population, higher levels of niacin intake were associated with decreased odds of glaucoma overall and in women.

Earlier Detection of Glaucoma Progression Using High-Density 3-Dimensional Spectral-Domain OCT Optic Nerve Volume Scans.

High-density 3D SD OCT neuroretinal rim measurements detected glaucoma progression approximately 1 to 2 years earlier compared with current clinically available structural tests (i.e., DP and 2D RNFL thickness measurements).

Associations between Statin Use and Glaucoma in the All of Us Research Program.

Statin use was associated with increased glaucoma likelihood in the overall adult AoU population with hyperlipidemia, in individuals with optimal or high LDL-C levels, and in individuals 60 to 69 years old.

Evaluating Discrepancies in Self-Reported Glaucoma and Electronic Health Records in the National Institutes of Health All of Us Database.

In the AoU database, we found that Black or African American and Hispanic or Latino individuals had higher odds of discordance between glaucoma diagnosis by self-report and EHR.

Association of Mood Disorders, Substance Abuse, and Anxiety Disorders in Children and Teens With Serious Structural Eye Diseases.

We found associations between eye disease in children and teens and mental illness. Understanding these relationships may improve mental illness screening and treatment in the pediatric population.

Twelve-Year Incidence of Open-angle Glaucoma: The Thessaloniki Eye Study.

The incidence of OAG was similar or higher compared with other White populations. The incidence of glaucoma in those with PEX was higher compared with the incidence of glaucoma in those without PEX.

Association Between Dietary Salt Intake and Open Angle Glaucoma in the Thessaloniki Eye Study.

In TES participants assessed for OAG in the prevalence and incidence phases, frequent salt intake may be associated with increased OAG in those who take antihypertensive medication.

Pointwise Methods to Measure Long-term Visual Field Progression in Glaucoma.

These results suggest GRI can detect long-term VF progression in glaucoma earlier than PLR or GPA. Validation with prospective designs may strengthen the generalizability and value of this method.

Association of Open-Angle Glaucoma With Dementia in California Medicare Beneficiaries.

In the 2019 California Medicare population, PXG is associated with an increased likelihood of VD in beneficiaries 65-74 years old, whereas other subtypes of POAG are associated with a decreased likelihood of any dementia.

The Trajectory of Glaucoma Progression in 2-Dimensional Structural-Functional Space.

We report a method to visualize the trajectory of a patient's glaucoma progression in a 2-dimensional S-F space. The slope of the trajectory of glaucoma progression is a function of the severity of the disease.

Expert Evaluation of Visual Field Decay in Glaucoma Correlates With the Fast Component of Visual Field Loss.

Expert qualitative evaluation of field series for change and rate of change correlate more closely with the fast component than with the slow component of VF decay.

Racial and Ethnic Differences in the Prevalence and Treatment Patterns for Neovascular Glaucoma in the American Academy of Ophthalmology IRIS® Registry.

Eyes of Black and Hispanic/Latino individuals with retinal ischemia in the IRIS Registry had higher likelihood of NVG and of IOP-lowering surgery for NVG.

Access to Eye Care Providers and Glaucoma Severity in the National Institutes of Health All of Us Research Program.

This study demonstrated that access to eye care services was associated with a higher prevalence of all levels of glaucoma severity; those with access to eye care services were more likely to undergo incisional surgery than those without access.

Disc Hemorrhages Are Associated With Localized Three-Dimensional Neuroretinal Rim Thickness Progression in Open-Angle Glaucoma.

Glaucoma progression detected by high-density 3D SD-OCT neuroretinal rim measurements preceded DH occurrence in the majority of patients.

Efficacy of Combined Suprachoroidal Stent and Cataract Surgery in Patients With Glaucoma.

Combined CyPass Micro-Stent implantation and cataract surgery may reduce glaucoma medication burden with a success rate of 28% to 42% at 1 year.

Associations Between Socioeconomic Factors and Neovascular Glaucoma in a United States Medicare Population.

In the 2019 CA Medicare population, associations between high SVI-SES, DMME, and increased prevalence of NVG were weakened after adjustment for demographic factors.

A Metascore of Multiple Imaging Methods to Measure Long-Term Glaucoma Structural Progression.

We report a method that converts Cirrus global RNFL and HRT global rim area normalized measurements to Spectralis global RNFL equivalent values to facilitate long-term structural follow-up.

Structural-Functional Glaucoma Progression Trajectory in 2-Dimensional Space.

We present a method that presents glaucoma progression in a 2D S/F space.

Strabismus Increases Glaucoma Risk in California Medicare Beneficiaries.

In the 2019 CA Medicare population, beneficiaries with strabismus and its subtypes were all associated with greater odds of POAG and NTG.

Associations between obesity, metabolic syndrome and glaucoma in the National Institutes of Health 'All of Us' research programme.

In AoU, higher BMI and increased WC were associated with a lower likelihood of glaucoma, while MetS was associated with an increased likelihood of glaucoma.

Cardiovascular Risk and Eye Health: A Cohort Study of the Pooled Cohort Equations and Ocular Disease Incidence.

In the AoU population, the single composite metric PCE meaningfully stratifies future risk for multiple ocular diseases, using information already available in primary care.

The Associations Between Glaucoma and Circadian Rhythm Sleep Disorders in California Medicare Beneficiaries.

In the 2019 CA Medicare population, beneficiaries with glaucoma had increased likelihood of CRSD and of any sleep-wake disorder.

Comparison of Event-based Analysis Versus Trend-based Analysis in the Detection of Glaucoma Progression by Optical Coherence Tomography 3-Dimensional Rim Measurements.

Compared with trend-based analysis, event-based analysis detected OCT structural progression in more glaucoma patients and at an earlier time point.

The Association between Glaucoma Severity and Hip Fractures in California Medicare Beneficiaries.

In the CA Medicare population, the presence of glaucoma was associated with decreased likelihood of hip fracture.

Prevalence and Severity of Glaucoma in the California Medicare Population.

In the 2019 CA Medicare population, multiple demographic and systemic factors were associated with increased likelihood of glaucoma, and beneficiaries with glaucoma had a high prevalence of moderate to severe disease.

Predictors of Glaucomatous Progression in Individuals with Small and Large Optic Discs.

Increased odds of glaucomatous progression were associated with Asian vs.

Author Response: Comparison of Local Structure-Function Relationships and Dynamic Range in Glaucoma.

Macular SD-OCT Outcome Measures: Comparison of Local Structure-Function Relationships and Dynamic Range.

GCIPL, GCL, and GCC demonstrated comparable SF relationships while FT, GCC, and GCIPL had the widest dynamic range.

Long-Term Outcomes of the Boston Type I Keratoprosthesis in the Management of Corneal Limbal Stem Cell Deficiency.

Boston type I keratoprosthesis implantation results in a significant improvement in CDVA in the majority of eyes with LSCD through 5 years after surgery, with better visual outcomes than eyes without LSCD.

Corneal Endothelium in Patients with Anterior Uveitis.

Observed relationships suggest that anterior segment inflammation adversely affects the corneal endothelium. Longitudinal studies are warranted to determine whether long-standing anterior uveitis increases risk of endothelial dysfunction, especially in the setting of intraocular surgery.

Course of Glaucomatous Visual Field Loss Across the Entire Perimetric Range.

Pointwise sigmoid regression had a better ability to fit perimetric decay into a subset of locations that traverse the entire range of perimetric measurements from near normal to near perimetric blindness compared with linear and exponential functions.

Enhancement of Visual Field Predictions with Pointwise Exponential Regression (PER) and Pointwise Linear Regression (PLR).

Smoothed VF data predicted better than unsmoothed data. Nearest neighbor provided the best predictions; PER also predicted consistently more accurately than PLR. Smoothing algorithms should be used when forecasting VF results with PER or PLR.

Trabeculectomy Can Improve Long-Term Visual Function in Glaucoma.

The results show that trabeculectomy slows the rate of perimetric decay and provide evidence of sustained, long-term improvement of visual function in glaucoma.

International Outcomes of the Boston Type I Keratoprosthesis in Stevens-Johnson Syndrome.

The Boston type I keratoprosthesis is an effective means to restore vision in individuals with SJS.

The Fast Component of Visual Field Decay Rate Correlates With Disc Rim Area Change Throughout the Entire Range of Glaucomatous Damage.

A decrease in rim area was significantly correlated with the fast VF component regardless of the baseline severity of glaucoma.

Reply: To PMID 25703477.

Valved Glaucoma Drainage Devices in Pediatric Glaucoma: Retrospective Long-term Outcomes.

Glaucoma drainage devices, such as the Ahmed glaucoma valve, have moderate long-term success rates in pediatric patients with glaucoma.

Long-Term Bleb-Related Infections After Trabeculectomy: Incidence, Risk Factors, and Influence of Bleb Revision.

This large case series with long-term follow-up demonstrates the incidence of bleb-related infections to be less than 2%, and describes the risk factors associated with bleb-related infections.

The association between glaucoma and immunoglobulin E antibody response to indoor allergens.

In NHANES, participants with glaucoma had significantly higher odds of sensitization to the cockroach and cat allergens compared to those without glaucoma.