Harry A. Quigley

Changes in Anterior Segment Morphology and Predictors of Angle Widening after Laser Iridotomy in South Indian Eyes.

In a South Indian population with PACS or PAC/PACG, LPI results in significant anterior chamber angle widening seen on both ASOCT and gonioscopy, although some degree of persistent iridotrabecular contact was present in approximately half…

Assessment of Cumulative Incidence and Severity of Primary Open-Angle Glaucoma Among Participants in the Ocular Hypertension Treatment Study After 20 Years of Follow-up.

In this study, only one-fourth of participants in the Ocular Hypertension Treatment Study developed visual field loss in either eye over long-term follow-up.

Factors Influencing Central Lamina Cribrosa Depth: A Multicenter Study.

Central LD was deeper in African descent eyes and influenced least by age, axial length, and sex, but more by ASCO area, when measured relative to the ASCO and sclera.

The Effects of Glaucoma on the Pressure-Induced Strain Response of the Human Lamina Cribrosa.

The stiffness of the LC pressure-strain response was greater in diagnosed glaucoma eyes and varied with glaucomatous axon damage.

Measuring Deformation in the Mouse Optic Nerve Head and Peripapillary Sclera.

The explant inflation test measures the strain response of the mouse ONH to applied IOP. Initial studies indicate regional differences in response to both acute and chronic IOP elevation within the ONH region.

Peripapillary Scleral Bowing Increases with Age and Is Inversely Associated with Peripapillary Choroidal Thickness in Healthy Eyes.

In non-highly myopic healthy eyes, outward peripapillary scleral bowing achieved substantial levels, was markedly increased with age, and was independently associated with decreased peripapillary choroidal thickness.

Regional Retinal Ganglion Cell Axon Loss in a Murine Glaucoma Model.

There was selectively greater loss of superior and temporal optic nerve axons of RGCs in mouse glaucoma at certain stages of damage. Differences in nerve area change suggest non-RGC responses differ between mouse strains.

Pressure-Induced Changes in Astrocyte GFAP, Actin, and Nuclear Morphology in Mouse Optic Nerve.

The changes in structure elucidated IOP-generated alterations that underlie astrocyte mechanotranslational responses relevant to glaucoma.

Improved Outcomes for Transscleral Cyclophotocoagulation Through Optimized Treatment Parameters.

Diode cyclophotocoagulation achieved reasonable IOP lowering, often without severe postoperative pain or complication.

Improving the Power of Glaucoma Neuroprotection Trials Using Existing Visual Field Data.

Selecting patients with low intertest variability can significantly improve the power and reduce the sample size needed in a trial.

Quantitative Microstructural Analysis of Cellular and Tissue Remodeling in Human Glaucoma Optic Nerve Head.

Alteration in LC structure in glaucoma involves migration of astrocytes into axonal bundles, change in astrocyte orientation and processes, production of basement membrane material, and thinning of connective tissue beams.

Low Sensitivity of the Van Herick Method for Detecting Gonioscopic Angle Closure Independent of Observer Expertise.

VHA, even when performed by experienced ophthalmologists, misses a substantial proportion of angle closure while incorrectly identifying roughly 1 in 8 open-angle eyes as closed.

Use of Optical Coherence Tomography by Nonexpert Personnel as a Screening Approach for Glaucoma.

OCT imaging may be performed by nonprofessional photographers on undilated patients, and quantitative parameters derived from the resultant images, particularly the vertical cup to disc ratio and the RNFL inferior quadrant thickness, demonstrate sensitivities and…

Sustained Dorzolamide Release Prevents Axonal and Retinal Ganglion Cell Loss in a Rat Model of IOP-Glaucoma.

A single injection of sustained release DPP protected against RGC loss and axial elongation in a rat model of IOP glaucoma.

Prevalence of Glaucoma in Europe and Projections to 2050: Findings from the European Eye Epidemiology Consortium.

The current and future burden of glaucoma in Europe may be substantially higher than previously estimated, with a considerable proportion of disease in the general population remaining undetected.

The Strain Response to Intraocular Pressure Decrease in the Lamina Cribrosa of Patients with Glaucoma.

With IOP lowering, the LC moves either into or out of the eye but, on average, expands in thickness and contracts in radius.

Long-term Functional Outcomes of Trabeculectomy Revision Surgery.

Revision of trabeculectomy provided successful resolution of complications associated with trabeculectomy surgery in many cases.

Electronically Monitored Corticosteroid Eye Drop Adherence after Trabeculectomy Compared to Surgical Success.

Adherence to frequent postoperative eye drops was high and can be successfully monitored remotely.

Glaucoma Neuroprotection Trials Are Practical Using Visual Field Outcomes.

Evaluation of Automated Segmentation Algorithms for Optic Nerve Head Structures in Optical Coherence Tomography Images.

Automated identification of ONH structures is comparable to observer markings for BMO and anterior LC position, making BMO a practical reference plane for algorithmic analysis.

The Histology of Human Glaucoma Cupping and Optic Nerve Damage: Clinicopathologic Correlation in 21 Eyes.

The Mechanisms of Neuroprotection by Topical Rho Kinase Inhibition in Experimental Mouse Glaucoma and Optic Neuropathy.

Topical Rip reduced RGC loss in GL and ON crush, with suppression of ROCK signaling in the retina and ON.

Comparison of the Biomechanics of the Mouse Astrocytic Lamina Cribrosa Between Glaucoma and Optic Nerve Crush Models.

We found alterations in the ex vivo mechanical behavior in eyes from mice with experimental glaucoma but not in those with crushed optic nerves.

The Need for Rigor in Evaluating Micropulse and Other New Procedures.

Author Response: Biomechanical Responses of Lamina Cribrosa to Intraocular Pressure Change Assessed by Optical Coherence Tomography in Glaucoma Eyes.

Long-term Remodeling Response in the Lamina Cribrosa Years after Intraocular Pressure Lowering by Suturelysis after Trabeculectomy.

Strains and LC border position changes measured years after IOP lowering are far larger than the immediate response to IOP lowering and indicate dramatic remodeling of the LC anatomical structure caused by IOP lowering and glaucoma progression.

Identifying Glaucoma in Primary Care Offices.

Familial Glaucoma-A Pedigree Revisited With Genetic Testing After 70 Years.

A Protective Eye Shield Reduces Limbal Strain and Its Variability During Simulated Sleep in Adults With Glaucoma.

Wearing a mask reduced limbal strain and variation in limbal strain during simulated FD sleep, particularly in eyes with past field worsening, as did some facial features.

The Strain Response to Intraocular Pressure Increase in the Lamina Cribrosa of Control Subjects and Glaucoma Patients.

LC strains were measurable 20 minutes after IOP increase, producing axial compression and greater peripheral strain than centrally.

Protruded retinal layers within the optic nerve head neuroretinal rim.

Protruded retinal layers are a component of MRW measurements in most normal subjects, occurring in almost 12% of all measurement points analysed.

Crowd-Sourced Glaucoma Study. Definition of Glaucoma for Research by a Large Group of Global Expert Evaluators.

The CSGS criteria represent parameter-defined consensus-based definition of glaucoma for clinical research.

Repeat Selective Laser Trabeculoplasty and Open-Angle Glaucoma.

Obstacles to Screening Today.

Approaches that would better provide care for glaucoma patients include eliminating the loss of follow-up and identifying glaucoma among family members of known glaucoma patients.

Measured Changes in Limbal Strain During Simulated Sleep in Face Down Position Using an Instrumented Contact Lens in Healthy Adults and Adults With Glaucoma.

Contact with a pillow in FD position during simulated sleep produced a sustained strain increase in glaucoma eyes, particularly those eyes with past progressive visual field loss.

Adherence With the Use of Target Intraocular Pressure for Glaucoma Patients in a Large University Practice.

Target IOP was recorded in the large majority of patient charts, but its use varied by physician and patient characteristics.

Author Response: Neurological Hemifield Test in Binasal Defects.