Rabiolo Alessandro

Risk Factors for Fast Visual Field Progression in Glaucoma.

In this cohort, older age, peak IOP, pseudoexfoliative glaucoma, and baseline MD were associated with the rate of glaucomatous VF worsening.

Longitudinal Macular Structure-Function Relationships in Glaucoma.

Correlations between central structural and functional rates of change were weak to fair in this cohort.

Comparison of Methods to Detect and Measure Glaucomatous Visual Field Progression.

GRI and PoPLR showed the highest proportion of series detected as progressing and shortest times to progression detection. GRI exhibited the best ability to detect progression in the simulated VF series.

Prediction of Visual Field Progression from OCT Structural Measures in Moderate to Advanced Glaucoma.

VF progression can be predicted with clinically relevant accuracy from baseline and longitudinal structural data. Further refinement of proposed models would assist clinicians with timely prediction of functional glaucoma progression and clinical decision making.

Predictors of Long-Term Visual Field Fluctuation in Glaucoma Patients.

This study identified novel predictors of VF fluctuation, and explains nearly 60% of the pointwise variance.

Cataract Surgery and Rate of Visual Field Progression in Primary Open-Angle Glaucoma.

Although all IOP parameters improved after cataract surgery, VFs continued to progress. Cataract surgery does not slow the apparent rate of glaucomatous VF decay as compared to rates measured during the progression of the cataract.

Quantification of Visual Field Variability in Glaucoma: Implications for Visual Field Prediction and Modeling.

VF variability increases with the severity of glaucoma damage and decreases with eccentricity.

Primary Deep Sclerectomy in Open-Angle Glaucoma: Long-Term Outcomes and Risk Factors for Failure.

Deep sclerectomy is an effective, long-lasting primary surgical procedure for OAG. Intraoperative MMC enhances survival, whereas higher preoperative IOP and postoperative maneuvers are predictors of increased failure.

A Method to Measure the Rate of Glaucomatous Visual Field Change.

GRI provides a robust measure of glaucomatous VF change, operates without discontinuity over the entire perimetric range, and can be used to identify fast progressors.

Relationship between Intraocular Pressure Fluctuation and Visual Field Progression Rates in the United Kingdom Glaucoma Treatment Study.

No evidence supports that either diurnal or long-term IOP fluctuation, as measured in clinical practice, are independent factors for glaucoma progression; other aspects of IOP, including mean IOP and peak IOP, may be more informative.

Hypotony-associated Complications After Deep Sclerectomy: Incidence, Risk Factors, and Long-term Outcomes.

The median (interquartile range) age and follow-up were 76 (67 to 82) years and 45.4 (20.9 to 79.8) months, respectively.

Comparison of Rates of Progression of Macular OCT Measures in Glaucoma.

GCC measurements are most likely to detect structural worsening along the spectrum of glaucoma severity. Although FMT rates of change are least influenced by baseline thickness, they partially reflect likely age-related ORL changes.

Risk Factors for Failure in Glaucoma Patients Undergoing Microshunt Implantation.

This study identified risk factors for Microshunt failure, highlighting the importance of high intraoperative MMC dose and careful patient selection to optimize surgical success.

Hypotony Failure Criteria in Glaucoma Surgical Studies and Their Influence on Surgery Success.

Hypotony failure criteria are highly heterogenous in the glaucoma literature, with few studies focusing on clinical manifestations.

Ganglion Cell Complex: The Optimal Measure for Detection of Structural Progression in the Macula.

GCC is the optimal macular measure for detection of structural change in eyes with moderate to severe glaucoma.

Estimating the Distribution of True Rates of Visual Field Progression in Glaucoma.

The distribution of "true" RoPs can be estimated with an exGaussian-LMM, improving model accuracy.

Comparison of Retinal Nerve Fiber Layer and Ganglion Cell-Inner Plexiform Layer Thickness Values Using Spectral-Domain and Swept-Source OCT.

Thickness values obtained with SD-OCT and SS-OCT are not directly interchangeable but potentially interconvertible. Both devices have a similar ability to discriminate glaucoma patients from GS and healthy subjects.

Validating Trend-Based End Points for Neuroprotection Trials in Glaucoma.

The trend-based methods can efficiently detect treatment effects defined by long-term FDA-compatible progression.

Pointwise Methods to Measure Long-term Visual Field Progression in Glaucoma.

These results suggest GRI can detect long-term VF progression in glaucoma earlier than PLR or GPA. Validation with prospective designs may strengthen the generalizability and value of this method.

Relationship Between Intraocular Pressure and the True Rate of Functional and Structural Progression in the United Kingdom Glaucoma Treatment Study.

VF appeared to deteriorate at a faster rate than structural measurements. However, this could be explained by the floor-effect from nonfunctional tissue. IOP induced a similar acceleration in RoP per mm Hg increase.

Combining Structural and Vascular Parameters to Discriminate Among Glaucoma Patients, Glaucoma Suspects, and Healthy Subjects.

Combining structural and vascular parameters in a structural-vascular index does not improve diagnostic ability over structural parameters alone.

Evaluating High Intraocular Pressure Criteria for Failure in Glaucoma Surgery: Impact on Estimated Success and Visual Field Rates.

The criteria for defining high IOP failure in glaucoma surgery are highly heterogeneous in the current literature.

Re: Gedde et al: Special Commentary: Reporting clinical endpoints in studies of minimally invasive glaucoma surgery (Ophthalmology. 2025;132:141-153).

Re: Singh et al.: Trabeculectomy Must Survive! (Ophthalmology Glaucoma. 2021;4:1-2).

A Metascore of Multiple Imaging Methods to Measure Long-Term Glaucoma Structural Progression.

We report a method that converts Cirrus global RNFL and HRT global rim area normalized measurements to Spectralis global RNFL equivalent values to facilitate long-term structural follow-up.

Re: Saeedi et al: Agreement and predictors of discordance of 6 visual field progression algorithms (Ophthalmology. 2019;126:822-828).

Effect of IOP-lowering treatment and Pentoxifylline on retrobulbar blood flow in normal tension glaucoma: a color doppler imaging study.

The Incidence of Clinically Significant Hypotony after Trabeculectomy.

A minority of eyes (20.1%) with numerical hypotony showed clinical manifestations of low IOP. Asian ethnicity and eyes that required suture lysis postoperatively tended to have less incidence of clinical sequelae of hypotony after trabeculectomy.

Adherence of glaucoma intervention studies to World Glaucoma Association guidelines.

Current literature shows poor adherence to WGA guidelines across both traditional and newer glaucoma surgeries, reflecting inadequate reporting and outdated recommendations.

Italian glaucoma virtual clinics: Developing a consensus for remote patient management.

This Delphi panel provides guidance for implementing glaucoma virtual clinics in Italy, establishing guidelines on patient selection, required assessments and staffing needs.

Comparison of Outcomes of Deep Sclerectomy, Canaloplasty, and Viscocanaloplasty: A Multicenter Study.

All 3 NPGS provide sustained IOP reduction, but DS and CP provide better success rates and IOP control.

Comparison of Methods to Deliver Mitomycin C in Trabeculectomy Surgery: A Systematic Review and Meta-Analysis.

Intraoperative sub-Tenon MMC injection is noninferior to intraoperative MMC-soaked sponges in trabeculectomy surgery in terms of surgical failure and IOP control, with a reduced number of medications, improved bleb morphology, and similar safety profile.

Association of Systemic Calcium Channel Blocker Use with Visual Field Progression in a Large Real-World Cohort from Glaucoma Clinics.

Calcium channel blocker use was statistically significantly associated with a slower rate of VF deterioration after multivariable adjustment.

Cataract Surgery and Rate of Visual Field Progression in Primary Open-Angle Glaucoma.

Author Response: The Distribution of True Visual Field Progression Rates in Glaucoma.

Optical Coherence Tomography Angiography Macular and Peripapillary Vessel Perfusion Density in Healthy Subjects, Glaucoma Suspects, and Glaucoma Patients.

Structural damage is evident both in the peripapillary and in macular areas.

Deep Sclerectomy With Mitomycin C and Injectable Cross-linked Hyaluronic Acid Implant: Long-term Results.

DS with Healaflow and MMC seems to be an effective and safe technique to lower IOP in patients affected by open-angle glaucoma, with few postoperative complications.

Nd:Yag laser goniopuncture for deep sclerectomy: efficacy and outcomes.

LGP is a relatively safe and effective complementary adjunct to deep sclerectomy that makes it possible to further lower IOP and avoid additional filtering surgery.